The value of red blood cell distribution width in subclinical hypothyroidism

Abstract

Objective: Therefore, we evaluated the relationship between the subclinical hypothyroidism and red cell distribution width (RDW) levels in a healthy population. Subjects and methods: The medical records of 23,343 consecutive health subjects were reviewed. Subjects were classified into four thyroid stimulating hormone (TSH) groups to determine the correlation between TSH and other variables in detail (0.3 to < 2.5 mU/L, 2.5 to < 5 mU/L, 5 to < 7.5 mU/L, and ≥ 7.5 mU/L). Results: In the multivariate linear regression analysis, RDW was associated with TSH levels, and e-GFR was inversely associated with TSH levels, respectively (standardized beta coefficient = 0.102, -0.019; p < 0.001, p < 0.001). After adjusting for age and sex, in the four groups, TSH levels were significantly correlated with RDW, estimated glomerular filtration rate (e-GFR), and free thyroxine (fT4) levels in all groups. Furthermore in the 4 th group, RDW levels were more strongly associated with TSH levels than in the other groups (p = 0.006). Conclusions: RDW levels are correlated with euthyroid and subclinical thyroid status. Notably, RDW is more correlated with subclinical hypothyroidism than the euthyroid status. This study presents the relationship between the RDW levels and thyroid function using TSH level in a large healthy population. TSH e outras variáveis, em detalhe (0,3 a < 2,5 mU/L; 2,5 a < 5 mU/L; 5 a < 7,5 mU/L; e ≥ 7,5 mU/L). Resultados: Na análise de regressão linear múltipla, a distribuição do tamanho dos eritrócitos (RWD) foi associada aos níveis de TSH, e a taxa estimada de filtração glomerular (e-GFR) foi inversamente associada aos níveis de TSH, respectivamente (coeficiente betapadronizado = 0,102; -0,019; p < 0,001; p < 0,001). Depois do ajuste para idade e sexo, nos quatro grupos, os níveis de TSH se correlacionaram significativamente com os níveis de RDW, e-GFR e tiroxina livre (fT4)

Thyroid Nodules with Atypia or Follicular Lesions of Undetermined Significance (AUS/FLUS): Analysis of Variables Associated with Outcome

“…This finding is consistent with recent similar studies (Jeong et al, 2013;Lee et al, 2014). Taller-than-wide shape (antero-posterior radius is greater than transvers radius), irregular margins and hypoechogenicity are also shown to be associated with malignancy in undetermined nodules (Jeong et al, 2013;Lee et al, 2014;Yu et al, 2014). In a study by Rosario et al, an original definition for "suspicious ultrasonographic findings" was used for AUS/FLUS nodules, which already has demonstrated the value for benign, follicular neoplasm and suspicious for malignancy groups (Rosario and Purisch, 2010;Rosario, 2014).…”

“…To our knowledge, there is no such study investigating the association between RDW levels and thyroid malignancies. Dorgalaleh et al, has shown that RDW levels are correlated with both hypothyroidism and hyperthyroidism (Dorgalaleh et al, 2013), whilst other studies have shown this correlation with primary and subclinical hypothyroidism (Bashir et al, 2012;Yu et al, 2014). In literature, there are also studies reported high RDW levels as a predictor of malignancy.…”

The hepcidin concentration decreases in hypothyroid patients with Hashimoto’s thyroiditis following restoration of euthyroidism

“…Yu et al . also reported an association between RDW and TSH in a large cohort of euthyroid and subclinically hypothyroid patients, where the correlation was strongest for TSH above the normal range 25 . In our study of hypothyroid patients, the RDW-CV levels were within normal ranges.…”

Subclinical hypothyroidism and cardiovascular risk

“…In the present study, RDW was found to be statistically higher in cases than in controls, even after excluding anaemic patients. Other authors have also observed increased RDW in SCH, as well as a correlation with TSH levels [34] suggesting that increased RDW may be due to altered erythropoiesis because of underlying inflammatory status. In the present study, we did not find a correlation between RDW and TSH.…”