Evaluation of antioxidant, cytotoxic, antibacterial effects and mineral levels of Verbascum lasianthum Boiss. ex Bentham

Abstract

The present study aimed to determine the antibacterial, antioxidant, cytotoxic activities and element levels of Verbascum lasianthum Boiss. ex Bentham. The free radical scavenging activity, total phenolic content, total antioxidant capacity, total oxidant capacity levels were analyzed as the antioxidant parameters. Seven bacteria and one yeast strains were used to determine the antimicrobial activity. The cytotoxic effects of plant extracts were determined using A549, MCF-7, HepG2 and SH-SY5Y cell lines. The fi ndings demonstrated that the antioxidant activity increased with an increase in the phenolic content of extracts. This species is rich in bio-elements such as Fe, Cu, Mn, Zn, and Mg. Different concentrations of extracts could have antibacterial activity. This plant had an apparent cytotoxic effect only in the A549 cell line and increased the proliferation in other cell lines. The fi ndings demonstrated that plant could be used alone or as a supplement to the current treatment protocols in diseases due to their antioxidant, antibacterial and cytotoxic effects. However, it is recommended that Verbascum L. species intended for use in therapy should be procured from areas where there is no soil pollution or organic farming is preferred.

Elucidating the chemical profile and biological studies of Verbascum diversifolium Hochst. extracts

“…mutense against SK-MEL cells ( Tatli and Akdemir, 2006b ), V. sinaiticum against Hep-2 and MCF-7 cells. ( Talib and Mahasneh, 2010 ), V. thapsus against A549 cells ( Zhao et al, 2011 ) , V. ovalifolium against SK-MEL-2 cell ( Luca et al, 2019 ), V. nigrum against A431 cells ( Iliescu et al, 2020 ), V. alceoides against HeLa and HUVEC cells ( Dinani et al, 2020 ), and V. lasianthum against A549 cells ( Hazman et al, 2021 ).…”

Antibacterial activity and phytochemical screening of traditional medicinal plants most preferred for treating infectious diseases in Habru District, North Wollo Zone, Amhara Region, Ethiopia

“…lasianthum Boiss. ex Bentham, was investigated for its biological activity and element content by [ 15 ]. The study revealed that different concentrations of V .…”

“…Numerous studies [12,13,15,17,19,45,46] conducted in various countries have reported a significant success rate in antibacterial activity tests, aligned with the ethnomedicinal background. A synthesis of findings from various studies reveals a consistent pattern of antibacterial efficacy across a diverse range of plants, despite differences in phytochemical composition and geographical origins.…”

“…Another species of Verbascum, V. lasianthum Boiss. ex Bentham, was investigated for its biological activity and element content by [15]. The study revealed that different concentrations of V. lasianthum extracts possess antibacterial activity, along with antioxidant and cytotoxic properties.…”

“…Benth. (Fabaceae) [12][13][14][15][16][17][18]. However, there is no investigation report available concerning the antibacterial and phytochemical properties of Solanum somalense Franchet.…”