Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet

Abstract

This work evaluated the effect of grape juice, red wine and resveratrol in liver parameters of rats submitted to high-fat diet. Experimental model was conducted with groups of adult females Rattus norvegicus: control (CG); high-fat (HG); grape juice (JG); red wine (RW) and resveratrol solution (RG). The high-fat diet signifi cantly altered hepatocytes and Kupffer cells in all treated groups. HG group presented severe steatosis followed hepatocyte ballooning and tissue damages. JG group minimized hepatic histological lesion caused by high-fat diet and WG group also induced steatosis and infl ammation in hepatocytes, similar to HG. Still, resveratrol protected the tissue against fatty liver disease by reducing fat infi ltration and infl ammation, indicating possible therapeutic effects on the liver. Cell cycle analysis showed that HG promoted damage to the tissue, reducing the viable cell content and increasing apoptosis, even when associated with wine consumption or isolated resveratrol. However, JG protected the liver against cell damage generated by the diet. Consumption of grape juice, even associated with a high-fat diet, represents a promising protection of the liver against cellular damage, but red wine further affects the tissue, and resveratrol alone was able to reduce damage but did not minimize cellular damage to the liver.

The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials

“…Resveratrol (3,5,4 -trihydroxy-trans-stilbene) is a non-flavonoid phenol produced by numerous plants in response to bacteria or fungi colonization. It can be found mainly in grape peel, blueberries, raspberries, mulberries, and peanuts while its high concentration in red wine explains, in part, the relatively low incidence of cardiovascular disease in the French population despite the prevalence of a high-fat diet (HFD) among this population [1]. Numerous studies have shown that resveratrol can prevent or slow the progression of a wide variety of diseases, including malignant tumours, neurodegenerative diseases, cardiovascular disorders, ischemic lesions, and viral infections [2][3][4][5].…”

Health benefits of first and second extraction drum‐dried pitted olive pomace

“…(2015) demonstrated that the intake of liquids rich in polyphenols minimizes the effects on systolic blood pressure and prevents nonalcoholic fatty infiltration in the liver of rats submitted to high‐fat diet. The consumption of bioactive compounds such as resveratrol has also been described as a hepato‐protector against the consumption of a diet high in saturated fatty acids (Bedê et al., 2020). In this context, we found that OP in diets reduced liver fat significantly, and this effect was enhanced when diets had increased OP.…”

Impact of different alcohol beverages on cardiovascular system

“…According to the latest reports, doses of red wine have not had a positive effect on liver cell damage caused by a high-fat diet. On the contrary, the wine has increased the damage already caused [23].…”

“…Further research would ultimately help to determine the impact of optimal red wine doses on health, especially since current scientific reports of red wine consumption attribute both negative and positive health effects [23].…”