Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na+, K+-ATPase activities found in the spleen from streptozotocin-induced diabetic rats

Abstract

How to cite: KOOLING J ET AL. 2019. Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na + , K + -ATPase activities found in the spleen from streptozotocin-induced diabetic rats. An Acad Bras Cienc 91: e20181330.Abstract: Type 1 diabetes (T1D) is the result of the selective destruction of the pancreatic β-cells by T cells of the immune system. Although spleen is a secondary lymphoid organ, it is also involved in the T1d pathogenesis. However, the alterations in a variety of cellular processes of this disease need to be further understood. We aimed to analyze the benefits of resveratrol, and its complexed form on diabetic complications in the spleen of rats. To this end, we investigated important enzymes of phosphoryl transfer network, and Na + , K + -ATPase activity. Wistar rats were divided into non-diabetic groups: Control, ethanol, Resveratrol, Hydroxypropyl-β-cyclodextrin, Resveratrol-hydroxypropyl-β-cyclodextrin, and diabetic groups with the same treatments. diabetes was induced by a single dose of 60 mg/kg of streptozocin intraperitoneally, and treatments by intragastric gavage once daily for 60 days. Hyperglycemia reduced creatine kinase activity, which was reversed by the administration of resveratrol. Na + , K + -ATPase activity was greatly affected, but it was reversed by resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin. This suggest an energetic imbalance in the spleen of diabetic rats, and in case this also occurs in the diabetic patients, it is possible that resveratrol supplementation could be beneficial to the better functioning of the spleen in diabetic patients.

Nanocapsules With Naringin And Naringenin Affect Hepatic and Renal Energy Metabolism Without Altering Serum Markers of Toxicity in Rats

“…Adenylate kinase (AK), CK and PK are key enzymes for balance the homeostasis energy. These systems operate together, when there a decrease in one enzyme the increase activity of the other can be compensated, for this reason is necessary evaluation for the system complete (Kolling et al 2019). The results of our study demonstrated that no changes were found in the PK activity on the groups compared to the control in both organs.…”

Resveratrol is an inhibitor of sodium‐dependent inorganic phosphate transport in triple‐negative MDA‐MB‐231 breast cancer cells

“…Resveratrol exerts an antitumour effect by regulating various targets in cancer cells (Ko et al, 2017). Resveratrol can fully recover Na + and K + ‐ATPase activity in spleen tissue from diabetic rats after hyperglycemia has altered the energetic homeostasis of this tissue by reducing enzyme activity levels (Kolling et al, 2019). Because the Na + gradient, maintained actively by Na + , K + ‐ATPase, and/or Na + ‐ATPase enzymes, plays a crucial role in inward Pi flux (Levi et al, 2019; Russo‐Abrahão et al, 2018), the ability of resveratrol to inhibit Na + ‐ATPase or Na + , K + ‐ATPase was investigated, as well as the consequent uptake of sodium‐dependent Pi.…”