A comparative study of phytoconstituents and antibacterial activity of in vitro derived materials of four Passiflora species

Abstract

Passiflora species are well known for their common use in popular medicine for the treatment of several diseases, such as insomnia, anxiety, and hysteria, in addition to their anti-inflammatory, antioxidant, analgesic and antibacterial potential. However, few data about the chemical composition and the medicinal potential of in vitro derived materials are available. Therefore, the goal of this work was to compare, for the first time, the phytoconstituents of in vitro derived materials of four Passiflora species, and evaluate the antibacterial potential of their extracts against 20 Gram-positive and negative strains. Chromatographic analysis indicated the presence of saponins in roots extracts from all studied species, whereas leaf extracts presented both saponins and flavonoids. Extracts from leaves and roots of P. alata and P. foetida exhibited a selective inhibitory activity against B. thuringiensis and S. pyogenes, which might be related to the presence of a high concentration of secondary metabolites, including flavonoids and saponins.

The Inhibitory Effect of Plant Extracts on Growth of the Foodborne Pathogen, Listeria monocytogenes

“…With regard to the mechanism of action of the plant extracts, it is known that plant polyphenols play important roles in plant defense mechanisms against bacteria, viruses, and fungi, and that they are the major components of plant extracts [40,41]. Plants belonging to group A in the current study were reported to have antibacterial activity mainly due to the presence of polyphenols [11,16,18,26,42], and their use was described as potential natural preservatives for the food industry [40,41,[43][44][45]. The mechanism of bacterial inhibition by polyphenols is complex.…”

“…P. foetida is a wild species commonly used for the treatment of hysteria, asthma, skin diseases with inflammation [13], and for many other anti-inflammatory and analgesic activities [14]. It also showed an antibacterial effect, e.g., against Escherichia coli HB 101, Streptococcus pyogenes, and Bacillus thuringiensis strains [15,16]. S. nemorosa deserves special mention since it gave very good results against L. monocytogenes in this study ( Table 2).…”

Pharmacological Properties and Chemical Profiles of Passiflora foetida L. Extracts: Novel Insights for Pharmaceuticals and Nutraceuticals

“…This also agrees with the calculated affinity of apigenin, chrysoeriol, luteolin, quercetin, and loliolide towards COX-2. Finally, considering the potential antimicrobial applications of P. foetida [1], methanol and water extracts were also tested against multiple dermatophytes strains, namely Tricophyton and Aerthrodrma species (Table 6), that are involved in skin disorders, including hyperpigmentation [63][64][65]. Both extracts were able to inhibit fungal growth and these results add to the aforementioned inhibitory activity against tyrosinase, which is crucial in the pharmacotherapy of hyperpigmentation.…”

“…The genus Passiflora belongs to the Passifloraceae family and the members of this genus have a great interest in their therapeutic properties against anxiety and irritability [1]. Thus, the genus is significantly valuable for the development of novel drugs [2].…”

Avaliação de extratos de plantas quanto à atividade antimicrobiana e à detoxificação de micotoxinas

“…De acordo com as interpretações de Aligiannis, Webster e Assis, nenhum dos extratos de plantas tiveram ação satisfatória contra A. parasiticus.Em relação a P. alata os dois extratos, bruto e liofilizado, não foram eficientes para os dois microrganismos testados. O gênero Passiflora é um dos poucos já estudado e explorado para uso humano com vários fitoquímicos, como alcalóides, flavonóides, saponinas, óleos essenciais e carotenóides, além de minerais, fibras e vitaminas(SIMÃO et al, 2018). No entanto, não existe muita literatura sobre a ação antimicrobiana envolvendo P. alata Mesmo assim, após testar um grande número de bactérias Gram-positivas e Gram-negativas, os autores encontraram atividade antimicrobiana contra Bacillus thuringiensis e Streptococcus pyogenes, e nenhuma ação contra S. aureus, assim como nossos achados.…”