2017
DOI: 10.1590/0001-3765201720160780
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Abstract: Natural steroids and triterpenes such as β-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester ex… Show more

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Cited by 3 publications
(3 citation statements)
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“…Therefore, together with these previously published studies, our data strongly suggest that betulinic acid can potentially be developed as a molecule of interest in cancer chemoprevention. Recently, it was reported that betulinic acid isolated from Mimosa caesalpiniifolia and its hexanoate derivative showed inhibition of cell proliferation against human ovarian carcinoma OVCAR-8 cell line [52,53]. Betulinic acid isolated from the stem bark extract of Physocarpus intermedius was shown to exhibit cytotoxicity against one of the ovarian cancer cell lines, SK-OV-3, in vitro [54].…”
Section: Resultsmentioning
confidence: 99%
“…Therefore, together with these previously published studies, our data strongly suggest that betulinic acid can potentially be developed as a molecule of interest in cancer chemoprevention. Recently, it was reported that betulinic acid isolated from Mimosa caesalpiniifolia and its hexanoate derivative showed inhibition of cell proliferation against human ovarian carcinoma OVCAR-8 cell line [52,53]. Betulinic acid isolated from the stem bark extract of Physocarpus intermedius was shown to exhibit cytotoxicity against one of the ovarian cancer cell lines, SK-OV-3, in vitro [54].…”
Section: Resultsmentioning
confidence: 99%
“…44 Terpenoid ester compounds have also been synthesized through an esterification reaction with an enzymatic catalyst. Geranyl acetate and geranil benzoate ester compounds have been synthesized from geraniol [3,7-dimethylocta-2,6-dien-1-ol (42)] namely 3,7-dimethylocta-2,6dien-1-yl acetate (43) and 3,7-dimethylocta-2,6-dien-1-yl benzoate (44). 3,7-dimethylocta-2,6-dien-1-yl acetate (43) was synthesized by the reaction between 3,7-dimethylocta-2,6-dien-1-ol (42) and vinyl acetate in toluene with the enzyme Pseudomonas cepacia lipase as a catalyst at 55˚C for 3 hours.…”
Section: Ester Derivatives Of Resveratrolsmentioning
confidence: 99%
“…This reaction produced 99% of ester. 20 Whereas 3,7-dimethylocta-2,6-dien-1-yl benzoate (44) was obtained by the esterification reaction of 3,7-dimethylocta-2,6-dien-1-ol (42) with benzoic acid, diethylazodicarboniclicate (DED) and triphenylphosphite (PPh 3 ) in THF at 0˚C. This process produced 95% ester product (Figure 10).…”
Section: Ester Derivatives Of Resveratrolsmentioning
confidence: 99%