2017
DOI: 10.1590/0001-3765201720150643
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Abstract: Linalool is the main compound of many essential oils and occurs in two isomeric forms: S-(+)-and R-(-)-linalool. This study aimed to determine if linalool isomers have different antimicrobial and anesthetic properties in fish. For this purpose, these compounds were previously isolated from Lippia alba (Mill.) N. E. Brown and Ocimum americanum L. essential oils. Antimicrobial effects were evaluated through the microdilution test against Aeromonas hydrophila, an important fish disease etiologic agent. Inductio… Show more

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Cited by 22 publications
(15 citation statements)
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“…The biological activities of linalool have been reported in racemate and each isomer, e.g., antileishmanial activity in rac-linalool [9], anesthetic activity in (S)-(+)-linalool [10], and acaricidal activity in (R)-(−)-linalool [11]. These enantiomers have different fragrance property [6,8] and biological activity between (R)-(−)-linalool and (S)-(+)-linalool [12]. Therefore, it is important to analyze enantiomeric ratios of terpenoid in extracts for utilization of plant components and elucidation of plant physiology.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The biological activities of linalool have been reported in racemate and each isomer, e.g., antileishmanial activity in rac-linalool [9], anesthetic activity in (S)-(+)-linalool [10], and acaricidal activity in (R)-(−)-linalool [11]. These enantiomers have different fragrance property [6,8] and biological activity between (R)-(−)-linalool and (S)-(+)-linalool [12]. Therefore, it is important to analyze enantiomeric ratios of terpenoid in extracts for utilization of plant components and elucidation of plant physiology.…”
Section: Introductionmentioning
confidence: 99%
“…contained more (S)-(+)-linalool than (R)-(−)-linalool. The biological activities such as fragrance property[6,8] and microbial activity[12] differ between (R)-(−)-linalool and (S)-(+)-linalool. Although linalool is used as a fragrance, currently, the commercial product is racemic or (R)-(−)excess linalool.…”
mentioning
confidence: 99%
“…Linalool, for example, is a racemic mixture of two enantiomers, (3S)-(+)-linalool (coryandrol) and (3R)-(−)-linalool (licareol), both of which have distinct properties [86,87]. The anesthetic property of (S)-(+)-and (R)-(−)-linalool has been tested on silver catfish (Rhamdia quelen), showing that (R)-(−)-linalol demonstrated clear advantages at a lower concentration [88]. Regarding anticonvulsant activity, de Sousa et al [89] demonstrated that (R)-(−)-linalool and the racemate form were more active than the (S)-(+) enantiomer, which had effects compatible with known anticonvulsant agents (diazepam, phenytoin).…”
Section: Resultsmentioning
confidence: 99%
“…Tambaqui juveniles (2.0 ± 0.2 g, 5.0 ± 0.2 cm) were individually transferred to continuously aerated aquaria containing 500 mL of water and 25, 50, 100 or 200 µL L -1 of EOAR or 50, 100, 200 or 300 µL L -1 of EOAP or synthetic linalool or linalool-AR, first diluted in ethanol (1:10) to enable better dilution in water. Previous tests were made with 200 µL L -1 of both EOs and compounds, based on studies of Cunha et al (2010) with the EO of Lippia alba chemotype linalool (around 47% linalool) and Heldwein et al (2014) and Silva et al (2017) with linalool in silver catfish. Based on the time to reach deep anesthesia using this concentration, the concentration range to be tested with each EO or compound was chosen.…”
Section: Methodsmentioning
confidence: 99%
“…Synthetic linalool (a mix of S-(+) and R-(-) isomers) presented anesthetic efficacy in common carp (Cyprinus carpio) (Mirghaed et al, 2016) and S-(+)-linalool isolated from the EO of Lippia alba had a similar sedation profile to the EO of this plant at a proportional linalool concentration in silver catfish (Rhamdia quelen) (Heldwein et al, 2014). The sedation was induced in silver catfish without differences between the compounds; however, R-(-)-linalool promoted faster anesthesia (Silva et al, 2017).…”
Section: E170128[2]mentioning
confidence: 99%