A polysaccharide fraction extracted from Pleurotus ostreatus mycelial biomass inhibit Sarcoma 180 tumor

Wisbeck, Elisabeth; Facchini, Jean Mary; Alves, Endi Pricila; Silveira, Marcia Luciane Lange; Gern, Regina Maria Miranda; Ninow, Jorge Luiz; Furlan, Sandra Aparecida

doi:10.1590/0001-3765201720150635

Cited by 20 publications

(11 citation statements)

References 30 publications

(18 reference statements)

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“…Different studies also demonstrated the antitumor and anticancer activities of POP against targeted cells. POP has cytotoxic activity when applied to murine lymphoid cancer cell line [109] and sarcoma 180 tumor cells [107]. A novel selenium polysaccharide fraction (Se-POP-3) can also can induce apoptosis and inhibit migration of cancer cells [110].…”

Section: Mushroom Species Containing Bioactive Polysaccharidesmentioning

confidence: 99%

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Niego

Rapior

Thongklang

et al. 2021

JoF

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Macrofungi production and economic value have been increasing globally. The demand for macrofungi has expanded rapidly owing to their popularity among consumers, pleasant taste, and unique flavors. The presence of high quality proteins, polysaccharides, unsaturated fatty acids, minerals, triterpene sterols, and secondary metabolites makes macrofungi an important commodity. Macrofungi are well known for their ability to protect from or cure various health problems, such as immunodeficiency, cancer, inflammation, hypertension, hyperlipidemia, hypercholesterolemia, and obesity. Many studies have demonstrated their medicinal properties, supported by both in vivo and in vitro experimental studies, as well as clinical trials. Numerous bioactive compounds isolated from mushrooms, such as polysaccharides, proteins, fats, phenolic compounds, and vitamins, possess strong bioactivities. Consequently, they can be considered as an important source of nutraceuticals. Numerous edible mushrooms have been studied for their bioactivities, but only a few species have made it to the market. Many species remain to be explored. The converging trends and popularity of eastern herbal medicines, natural/organic food product preference, gut-healthy products, and positive outlook towards sports nutrition are supporting the growth in the medicinal mushroom market. The consumption of medicinal mushrooms as functional food or dietary supplement is expected to markedly increase in the future. The global medicinal mushroom market size is projected to increase by USD 13.88 billion from 2018 to 2022. The global market values of promising bioactive compounds, such as lentinan and lovastatin, are also expected to rise. With such a market growth, mushroom nutraceuticals hold to be very promising in the years to come.

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Section: Mushroom Species Containing Bioactive Polysaccharidesmentioning

confidence: 99%

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Niego

Rapior

Thongklang

et al. 2021

JoF

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“…White rot fungi have stirred the scientific community’s interest due to their medicinal properties, which include immune system modulation, hypoglycemic and antithrombotic activity and antihypertensive, anti-inflammatory, antimicrobial and antitumor properties, as well as the ability to lower blood cholesterol levels [ 24 , 36 , 37 , 38 ]. The two white rot fungi P. ostreatus and L. edodes are two of the most highly consumed edible mushrooms in many countries [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…The antitumor effect of these mushroom products was related to biomolecules including glucans, ergosterol, proteoglucans and amino acids (arginine and glutamine) [ 23 ]. The postulated mechanism underlying this effect may include the stimulation of T-lymphocytes, suppression of neovascularization and induction of cancer cell death, in addition to triggering the immune response against cancer cells [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Proteome Analysis and In Vitro Antiviral, Anticancer and Antioxidant Capacities of the Aqueous Extracts of Lentinula edodes and Pleurotus ostreatus Edible Mushrooms

et al. 2021

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In this study, we examined aqueous extracts of the edible mushrooms Pleurotus ostreatus (oyster mushroom) and Lentinula edodes (shiitake mushroom). Proteome analysis was conducted using LC-Triple TOF-MS and showed the expression of 753 proteins by Pleurotus ostreatus, and 432 proteins by Lentinula edodes. Bioactive peptides: Rab GDP dissociation inhibitor, superoxide dismutase, thioredoxin reductase, serine proteinase and lectin, were identified in both mushrooms. The extracts also included promising bioactive compounds including phenolics, flavonoids, vitamins and amino acids. The extracts showed promising antiviral activities, with a selectivity index (SI) of 4.5 for Pleurotus ostreatus against adenovirus (Ad7), and a slight activity for Lentinula edodes against herpes simplex-II (HSV-2). The extracts were not cytotoxic to normal human peripheral blood mononuclear cells (PBMCs). On the contrary, they showed moderate cytotoxicity against various cancer cell lines. Additionally, antioxidant activity was assessed using DPPH radical scavenging, ABTS radical cation scavenging and ORAC assays. The two extracts showed potential antioxidant activities, with the maximum activity seen for Pleurotus ostreatus (IC50 µg/mL) = 39.46 ± 1.27 for DPPH; 11.22 ± 1.81 for ABTS; and 21.40 ± 2.20 for ORAC assays. This study encourages the use of these mushrooms in medicine in the light of their low cytotoxicity on normal PBMCs vis à vis their antiviral, antitumor and antioxidant capabilities.

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“…The intracellular polysaccharide fraction extracted from the mycelial biomass of P . ostreatus exhibited a significant antitumor activity at lower doses of 10 and 30 mg/kg to reduce sarcoma 180 tumors in the mice model (Wisbeck et al., 2017). Table 3 summarizes the antitumor mechanism of Pleurotus spp.…”

Section: Antitumor Efficacymentioning

confidence: 99%

Biological activities of Pleurotus spp. polysaccharides: A review

Sharma

Tripathi

2021

J. Food Biochem.

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Mushrooms are consumed for their nutrients and therapeutic bioactive compounds and are used medicinally in Chinese and Japanese medicine traditions since time immemorial. Members of the genus Pleurotus form a heterogeneous group of edible species with outstanding nutritional profiles rich in fiber, vitamins (thiamine, riboflavin, ascorbic acid, ergosterine, and niacin), micro and macro‐elements (phosphorus and iron), and carbohydrates. Pleurotus is one of the most diversified medicinal and edible mushrooms related to the composition of chemical structures such as polysaccharides, glycoproteins, and secondary metabolites such as alkaloids and betalains. The cultivation of Pleurotus spp. on lignocellulosic wastes represents one of the most economically and cost‐effective organic recycling processes, especially for the utilization of different feasible and cheap recyclable residues. Also, several Pleurotus spp. have the ability to remove phenolic compounds from wastewater with the action of phenoloxidase activity. Here, we have reviewed the chemistry of such polysaccharides and their reported biological activities, namely, anti‐inflammatory, immunomodulatory, anti‐diabetic, anti‐tumor, antioxidant, etc. The mechanism of action and effects of novel polysaccharides extracted from various species of Pleurotus have been studied. The current study will be beneficial for guiding future research projects on the above concept and investigating more deeply the health of human beings. Practical applications Mushrooms are one of the most delicious foods around the globe and have many medicinal properties for decades. Various Pleurotus species have been in focus in recent years because of their palatability and medicinal importance too. It contains many bioactive compounds among which polysaccharides are valued to a great extent. Many biological activities are exerted by polysaccharides derived from the Pleurotus spp., namely, anti‐tumor, antioxidant, and many more. They are responsible for significant physiological responses in animals, animal‐alternative in vitro models, and humans. Their important physicochemical characteristics benefit their use in the food industry as well. So, the biological activities of these Pleurotus spp. polysaccharides will provide an insight to develop Pleurotus spp. as functional foods, because of their nutritional value and presence of bioactive components.

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A polysaccharide fraction extracted from Pleurotus ostreatus mycelial biomass inhibit Sarcoma 180 tumor

Cited by 20 publications

References 30 publications

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Proteome Analysis and In Vitro Antiviral, Anticancer and Antioxidant Capacities of the Aqueous Extracts of Lentinula edodes and Pleurotus ostreatus Edible Mushrooms

Biological activities of Pleurotus spp. polysaccharides: A review

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