Phenolic compounds and anticancer activity of commercial sugarcane cultivated in Brazil

Alves, Vanessa Gomide; Souza, Alan G.; Chiavelli, Lucas Ulisses Rovigatti; Ruiz, Ana Lúcia Tasca Góis; Carvalho, João Ernesto de; Pomini, Armando M.; Silva, Cleuza C.

doi:10.1590/0001-3765201620150349

Cited by 25 publications

(11 citation statements)

References 26 publications

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“…The most abundant flavonoid compounds in S. officinarum are flavones (i.e., naringenin, apigenin, tricin and luteolin). These compounds the colour of sugarcane juice in addition to its health benefits due to their high antioxidant potential and capacity to protect cells from degenerative diseases [26]. Luteolin was identified in the low-field region from its characteristic signal at δ H 6.73 ppm (d, J = 2.3 Hz assigned to H-6) and another proton doublet at δ H 6.75 ppm ( J = 2.3 Hz assigned to H-8).…”

Section: Resultsmentioning

confidence: 99%

Profiling Metabolites and Biological Activities of Sugarcane (Saccharum officinarum Linn.) Juice and its Product Molasses via a Multiplex Metabolomics Approach

et al. 2019

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Sugarcane (Saccharum officinarum L.) is an important perennial grass in the Poaceae family cultivated worldwide due to its economical and medicinal value. In this study, a combined approach using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy was employed for the large-scale metabolite profiling of sugarcane juice and its by-product molasses. The polyphenols were analysed via UPLC-UV-ESI-MS, whereas the primary metabolites such as sugars and organic and amino acids were profiled using NMR spectroscopy and gas chromatography/mass spectrometry (GC/MS). UPLC/MS was more effective than NMR spectroscopy or GC/MS for determining differences among the metabolite compositions of the products. Under the optimized conditions, UPLC/MS led to the identification of 42 metabolites, including nine flavonoids, nine fatty acids, and two sterols. C/O Flavone glycosides were the main subclass detected, with tricin-7-O-deoxyhexosyl glucuronide being detected in sugarcane and molasses for the first time. Based on GC/MS analysis, disaccharides were the predominant species in the sugarcane juice and molasses, with sucrose accounting for 66% and 59%, respectively, by mass of all identified metabolites. The phenolic profiles of sugarcane and molasses were further investigated in relation to their in vitro antioxidant activities using free radical scavenging assays such as 2,2-Diphenyl-1-picrylhydrazyl free radical-scavenging ability (DPPH), Trolox equivalent antioxidant capacity (TEAC) and ferric reducing antioxidant power (FRAP). In view of its higher total phenolic content (TPC) (196 ± 2.1 mg GAE/100 g extract) compared to that of sugarcane juice (93 ± 2.9 mg GAE/100 g extract), molasses exhibited a substantially higher antioxidant effect. Interestingly, both extracts were also found to inhibit α-glucosidase and α-amylase enzymes, suggesting a possible antihyperglycaemic effect. These findings suggest molasses may be a new source of natural antioxidants for functional foods.

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Section: Resultsmentioning

confidence: 99%

Profiling Metabolites and Biological Activities of Sugarcane (Saccharum officinarum Linn.) Juice and its Product Molasses via a Multiplex Metabolomics Approach

et al. 2019

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“…VA is widely used in the food industry as flavouring agent, food additive, and preservative. We detected VA in various foods, such as herbs, tea, coffee, wine, and beer [2][3][4][5][6][7]. VA possesses powerful antioxidant functions, antihypotensive effects, cardioprotective effects, hepatoprotective effects, and antiapoptotic activities [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Vanillic Acid Alleviates Acute Myocardial Hypoxia/Reoxygenation Injury by Inhibiting Oxidative Stress

Yao

Jiao

Qin

et al. 2020

Oxidative Medicine and Cellular Longevity

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Oxidative stress is an important factor of myocardial hypoxia/reoxygenation (H/R) injury. Our research focuses on how to reduce the cardiac toxicity caused by oxidative stress through natural plant extracts. Vanillic acid (VA) is a phenolic compound found in edible plants and rich in the roots of Angelica sinensis. Experimental studies have provided evidence for this compound’s effectiveness in cardiovascular diseases; however, its mechanism is still unclear. In this study, molecular mechanisms related to the protective effects of VA were investigated in H9c2 cells in the context of H/R injury. The results showed that pretreatment with VA significantly increased cell viability and decreased the percentage of apoptotic cells, as well as lactate dehydrogenase and creatine phosphokinase activity, in the supernatant, accompanied by reduced levels of reactive oxygen species and reduced caspase-3 activity. VA pretreatment also restored mitochondrial membrane potentials. Moreover, preincubation with VA significantly attenuated mitochondrial permeability transition pore activity. VA administration upregulated adenosine monophosphate-activated protein kinase α2 (AMPKα2) protein expression, and interestingly, pretreatment with AMPKα2-siRNA lentivirus effectively attenuated the cardioprotective effects of VA in response to H/R injury.

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“…Grasses hold a lot of syntheses as about 27 have been partly listed from the main cereals (sorghum, oat, barley, wheat, maize, Spelt). These chemicals and biologicals act as anticancer [37,66], increasing milk production [67], antifungal, antibacterial [37], anthelmintic, anti-amoebic, cyclooxygenase (COX) I and II inhibitory activity [68], dysmenorrheal and uterine relaxing activities.…”

Section: Grasses and Grassland Synthesesmentioning

confidence: 99%

Introductory Chapter: Milestones inGrasses and GrasslandResearch

Kindomihou¹

2020

Grasses and Grassland Aspects

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Phenolic compounds and anticancer activity of commercial sugarcane cultivated in Brazil

Cited by 25 publications

References 26 publications

Profiling Metabolites and Biological Activities of Sugarcane (Saccharum officinarum Linn.) Juice and its Product Molasses via a Multiplex Metabolomics Approach

Profiling Metabolites and Biological Activities of Sugarcane (Saccharum officinarum Linn.) Juice and its Product Molasses via a Multiplex Metabolomics Approach

Vanillic Acid Alleviates Acute Myocardial Hypoxia/Reoxygenation Injury by Inhibiting Oxidative Stress

Introductory Chapter: Milestones inGrasses and GrasslandResearch

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