2015
DOI: 10.1590/0001-3765201520130400
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Abstract: We have recently shown that chronic fluoxetine treatment acted significantly increasing plasma norepinephrine and epinephrine concentrations both in control and chronically stressed adult male rats. However, possible effects of fluoxetine on catecholamine synthesis and re-uptake in adrenal medulla have been largely unknown. In the present study the effects of chronic fluoxetine treatment on tyrosine hydroxylase, a rate-limiting enzyme in catecholamine synthesis, as well as a norepinephrine transporter and vesi… Show more

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Cited by 9 publications
(5 citation statements)
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“…[ 54,55 ] After PHGG treatment, the TH mRNA levels decreased probably due to PHGG improving the intestinal flora to alleviate colonic inflammation. It should be noted that fluoxetine, which has been perceived as contributing to the high expression of TH, [ 56 ] increased all the TH mRNA levels in all the related groups. On the other hand, there was no significant difference in the TPH mRNA levels among these groups.…”
Section: Discussionmentioning
confidence: 99%
“…[ 54,55 ] After PHGG treatment, the TH mRNA levels decreased probably due to PHGG improving the intestinal flora to alleviate colonic inflammation. It should be noted that fluoxetine, which has been perceived as contributing to the high expression of TH, [ 56 ] increased all the TH mRNA levels in all the related groups. On the other hand, there was no significant difference in the TPH mRNA levels among these groups.…”
Section: Discussionmentioning
confidence: 99%
“…It has been proposed that alterations in the activity of Th in the central noradrenergic system may lead to depression [ 58 ]. Antidepressant Fluoxetine could reverse depressive symptoms by increasing plasma catecholamine levels via increasing Th in CUMS rats [ 59 ]. Another study found essential oil from Asarum heterotropoides could effectively inhibit depression-like behavioral responses by increasing brain Th expression in mice challenged with stress [ 60 ].…”
Section: Discussionmentioning
confidence: 99%
“…The sympathetic nerve fibers, from the autonomic nervous system, richly innervate the adrenal medulla [28,35]. The adrenal chromaffin cells are modified neurons derived from the sympathetic nervous system [29].…”
Section: Endocrinophysiological Systemmentioning
confidence: 99%
“…The regulation of adrenal catecholamine synthesis is a complex process. Nerve discharges activate the enzyme tyrosine hydroxylase and initiate synthesis [35]. However, plasma NEP inhibits this first step in synthesis through a negative feedback mechanism.…”
Section: Endocrinophysiological Systemmentioning
confidence: 99%
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