2013
DOI: 10.1590/0001-376520130013
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Abstract: Although Alzheimer's disease is a brain disorder, a number of peripheral alterations have been found in these patients; however, little is known about how the key genes involved in the pathophysiology express in peripheral cells such as lymphocytes during normal compared to neuropathological ageing. We analysed the expression of tau, of the amyloid precursor protein, of nicastrin and of the β-site APP cleaving enzyme genes by RT-PCR in lymphocytes from a small group of late-onset Alzheimer's disease patients, … Show more

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Cited by 11 publications
(6 citation statements)
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“…Moreover, upregulated p53 levels were shown to be associated with a decreased proteasome activity in cells with mutated PS1 [59]. Consistently with low APP expression levels in B cells [60], p53 transcriptional regulation was not detected in our study in FAD cells; neither was lower degradation. Instead, this is the first documentation of the link between PS1 mutants and the activation of p53 by phosphorylation at Ser15, resulting in the upregulation of p21 levels.…”
Section: Discussionsupporting
confidence: 65%
“…Moreover, upregulated p53 levels were shown to be associated with a decreased proteasome activity in cells with mutated PS1 [59]. Consistently with low APP expression levels in B cells [60], p53 transcriptional regulation was not detected in our study in FAD cells; neither was lower degradation. Instead, this is the first documentation of the link between PS1 mutants and the activation of p53 by phosphorylation at Ser15, resulting in the upregulation of p21 levels.…”
Section: Discussionsupporting
confidence: 65%
“…To date, no study has attempted to verify Aβ production in lymphocytes. BACE1 expression was found in lymphocytes but no nicastrin expression was reported [47], and this indicates low probability of Aβ peptides production by the γ secretase and low potential of amyloid cascade components as AD biomarkers in lymphocytes.…”
Section: Prospective Ad Biomarkers In Lymphocytesmentioning
confidence: 86%
“…To date, no study has attempted to verify Aβ production in lymphocytes. BACE1 expression was found in lymphocytes but no nicastrin expression was reported [47], and this indicates low probability of Aβ peptides production by the γ secretase and low potential of amyloid cascade components as AD biomarkers in lymphocytes.Oxidative & mitochondrial stress in lymphocytes Increasing evidence shows elevated levels of oxidative stress markers in nucleic acids, carbohydrates, lipids and proteins in AD patients' brains, as well as in the periphery. The results showing oxidative and mitochondrial stress markers in AD lymphocytes were recently reviewed in [46].…”
mentioning
confidence: 86%
“…In subjects with vascular dementia, healthy elderly persons and Alzheimer’s disease patients, there were no significant changes in the lymphocytic amyloid protein precursor and β-secretase mRNA, but their mRNA were present in lymphocytes [ 43 , 44 ]. Above data positively correlates with our observations of decreased expression in post-asphyxia lymphocytes, the amyloid protein precursor and β-secretase genes.…”
Section: Discussionmentioning
confidence: 99%