2019
DOI: 10.15430/jcp.2019.24.2.65
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Abstract: Peroxiredoxins (Prxs) are antioxidant enzymes that protect cells from oxidative stress by reducing intracellular accumulation of reactive oxygen species (ROS). In mammalian cells, the six Prx isoforms are ubiquitously expressed in diverse intracellular locations. They are involved in the regulation of various physiological processes including cell growth, differentiation, apoptosis, immune response and metabolism as well as intracellular ROS homeostasis. Although there are increasing evidences that Prxs are in… Show more

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Cited by 36 publications
(26 citation statements)
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“…PRDXs are typical peroxidases for the removal of cellular peroxides [1,2]. To investigate the biological roles of PRDXs, numerous approaches have been performed using the cell culture system.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…PRDXs are typical peroxidases for the removal of cellular peroxides [1,2]. To investigate the biological roles of PRDXs, numerous approaches have been performed using the cell culture system.…”
Section: Discussionmentioning
confidence: 99%
“…The peroxiredoxin (PRDX) family has peroxidase activity to remove peroxides, including hydrogen peroxide (H 2 O 2 ), organic hydroperoxides, and peroxynitrite [1,2]. PRDXs are widely distributed in almost all organisms and there are more than 3500 members in this protein family [3].…”
Section: Introductionmentioning
confidence: 99%
“…Peroxiredoxin 5 is an anti-oxidant enzyme that decreases hydrogen peroxide and alkyl hydroperoxide. It plays a critical role in cellular homeostasis by scavenging cellular ROS and ameliorates glutamate-induced apoptosis in neuronal cells culture [14,15]. Moreover, knockdown of peroxiredoxin 5 increases apoptosis caused by glutamate exposure [16].…”
Section: Discussionmentioning
confidence: 99%
“…Multiple reports show upregulation of PRDXs in cancer and involvement in resistance to radiation therapy [214,215]. Currently, no approved inhibitors of PRDXs are available, but there are ongoing research efforts in the development of several compounds in preclinical development.…”
Section: The Peroxiredoxin-thioredoxin Systemmentioning
confidence: 99%