2012
DOI: 10.1517/13543776.2013.751972
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Abstract: A pharmaceutical composition composed of several traditional Chinese medicines is claimed to treat Age-related Macular Degeneration (AMD). This represents a novel and alternative therapeutic solution for wet AMD, with the potential advantage of treating both the symptoms and the underlying causes of this devastating degenerative retinal disease.

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Cited by 57 publications
(5 citation statements)
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“…Combination therapies have been explored in order to reduce the frequency of intravitreal anti-VEGF injections and the risk of relevant side-effects due to complete VEGF inactivity and steroid administration (21,22). Investigations regarding other therapeutic strategies may prolong the interval of treatment and provide alternatives to the current CNV treatment (5,23).…”
Section: Discussionmentioning
confidence: 99%
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“…Combination therapies have been explored in order to reduce the frequency of intravitreal anti-VEGF injections and the risk of relevant side-effects due to complete VEGF inactivity and steroid administration (21,22). Investigations regarding other therapeutic strategies may prolong the interval of treatment and provide alternatives to the current CNV treatment (5,23).…”
Section: Discussionmentioning
confidence: 99%
“…The pharmaceutical composition consists of a number of TCM components, including Astragalus membranaceus Bunge, Angelica sinensis, Poria cocos Wolf, Fritillaria thunbergii, Panax pseudoginseng, CRRR, pollen Typhae and Curcuma aromatica Salisb. The compounds in the composition were shown to be capable of targeting the hallmarks of AMD, including oxidative stress, RPE cytotoxicity, inflammation and vascular edema (5). The composition contains raw materials from herbs that can eliminate inflammation (25)(26)(27)(28)(29)(30), modulate immunity (31)(32)(33)(34)(35)(36)(37), promote blood circulation in order to remove blood stasis (38,39), prevent bleeding (40,41) and promote the absorption of macular exudates, edema and hemorrhage, as well as reduce the leakage and area of CNV (42).…”
Section: Discussionmentioning
confidence: 99%
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