2019
DOI: 10.14785/lymphosign-2018-0016
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Abstract: Histamine is a bioactive amine which is considered a key player in the allergic response. Thus, histamine receptor blockers (antihistamines) play an important role in the treatment of a number atopic diseases such as allergic rhinitis, conjunctivitis, and acute and chronic forms of urticaria. Histamine is produced by immune cells but also by bacteria in the gut. Beyond its role in the acute allergic response, histamine exerts numerous effects by binding to its 4 pleiotropic G-protein coupled histamine receptor… Show more

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Cited by 9 publications
(4 citation statements)
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“…However, the term antihistaminergic drugs relates primarily to antagonists of the H1 receptor. In the short term, H1 receptors are mostly involved in allergic inflammation, H2 receptors are involved in the regulation of gastric acid secretion, H3 receptors control neurotransmission, and H4 receptors are responsible for immunomodulation ( 83 ). The disadvantage of the first generation of histaminergic receptor antagonists is crossing the blood–brain barrier (BBB); therefore, they exhibit sedative properties.…”
Section: Classic Pharmacological Approach For Immunomodulationmentioning
confidence: 99%
“…However, the term antihistaminergic drugs relates primarily to antagonists of the H1 receptor. In the short term, H1 receptors are mostly involved in allergic inflammation, H2 receptors are involved in the regulation of gastric acid secretion, H3 receptors control neurotransmission, and H4 receptors are responsible for immunomodulation ( 83 ). The disadvantage of the first generation of histaminergic receptor antagonists is crossing the blood–brain barrier (BBB); therefore, they exhibit sedative properties.…”
Section: Classic Pharmacological Approach For Immunomodulationmentioning
confidence: 99%
“…Antihistamines (AHs), due to their proven strong anti-inflammatory and anti-allergenic properties, are widely used worldwide as first-line drugs in the treatment of numerous allergic diseases [ 10 ]. Their mechanism of action involves stabilization of the inactive form of histamine H1 receptor, thereby blocking the action of histamine [ 11 , 12 , 13 ], which, as a major mediator of inflammatory response, not only underlies many allergic diseases [ 14 ], but is also directly involved in the regulation of biological processes during the development of various types of cancer, including cervical cancer [ 1 , 15 , 16 ]. Hence, in recent years, attention has been focused on the potential antitumor properties of antihistamines, both among the long-used and new second-generation representatives.…”
Section: Introductionmentioning
confidence: 99%
“…The immunomechanism of allergic conjunctivitis is characterized by IgEmediated mast cell degranulation and/or T lymphocytemediated immunohypersensitivity response. 12,34,58 The aim of this work was to formulate and evaluate MZL in SLNs using different lipid amounts and surfactant percentages. Furthermore, adopting a 3 2 randomized full factorial design to investigate the main influences and interactions of independent variables on the physicochemical properties of the prepared MZL-SLNs, ie, mean particle size (MPS), entrapment efficiency % (EE %), polydispersity index (PDI), and zeta potential (ZP).…”
Section: Introductionmentioning
confidence: 99%
“…The immunomechanism of allergic conjunctivitis is characterized by IgE-mediated mast cell degranulation and/or T lymphocyte–mediated immunohypersensitivity response. 12 , 34 , 58 …”
Section: Introductionmentioning
confidence: 99%