2017
DOI: 10.1371/journal.ppat.1006653
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Abstract: Several conditions associated with reduced gastric acid secretion confer an altered risk of developing a gastric malignancy. Helicobacter pylori-induced atrophic gastritis predisposes to gastric adenocarcinoma, autoimmune atrophic gastritis is a precursor of type I gastric neuroendocrine tumours, whereas proton pump inhibitor (PPI) use does not affect stomach cancer risk. We hypothesised that each of these conditions was associated with specific alterations in the gastric microbiota and that this influenced su… Show more

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Cited by 152 publications
(142 citation statements)
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“…29 Recently, the profile of the gut microbiota has been found to affect the pathophysiology of irritable bowel syndrome and chronic functional constipation. 32,33 In our present study, the prevalence of H. pylori-positive patients with symptoms of chronic constipation was 48.8% in the GSRS questionnaire and 47.0% in the Izumo scale. In general, the profile of the gut microbiota differs between H. pylori-positive and H. pylori-negative patients in relation to sex, age, race, H. pylori strain, and severity of gastric mucosal atrophy.…”
Section: -Hydroxytryptamine 4 Serotonin Receptor Agonists Bulkingsupporting
confidence: 46%
“…29 Recently, the profile of the gut microbiota has been found to affect the pathophysiology of irritable bowel syndrome and chronic functional constipation. 32,33 In our present study, the prevalence of H. pylori-positive patients with symptoms of chronic constipation was 48.8% in the GSRS questionnaire and 47.0% in the Izumo scale. In general, the profile of the gut microbiota differs between H. pylori-positive and H. pylori-negative patients in relation to sex, age, race, H. pylori strain, and severity of gastric mucosal atrophy.…”
Section: -Hydroxytryptamine 4 Serotonin Receptor Agonists Bulkingsupporting
confidence: 46%
“…Using this technique, Parsons et al studied the gastric microbiota of 75 individuals with H pylori ‐induced atrophic gastritis, autoimmune atrophic gastritis and PPI use, conditions associated with similar levels of hypochlorhydria, but different risks and types of gastric cancer—specifically neuroendocrine and adenocarcinoma. Comparing the 19 PPI users from this cohort with 20 healthy controls, a significant reduction in bacterial richness and diversity was detected in gastric biopsies of the PPI users, along with significant decreases in the genera Actinobacillus and Tannerella (Tables and ).…”
Section: Resultsmentioning
confidence: 92%
“…A significant portion of the taxa identified by sequencing may therefore not be metabolically active. Only one study addressed this issue by sequencing reverse‐transcribed rRNA, while the more feasible approach—the use of propidium monoazide, a DNA intercalator selectively penetrating into cells with compromised membrane integrity—has not yet been used in this context. Propidium monoazide renders DNA insoluble so it gets lost during subsequent DNA extraction for sequencing analysis …”
Section: Discussionmentioning
confidence: 99%
“…However, Achromobacter species were completely absent in a Chinese validation cohort, indicating that geographical origin might have similar if not stronger impact on the gastric microbiota composition than the pathology itself. One study found that the stomachs of autoimmune atrophic gastritis patients were colonised by Gemella and Bosea unlike any other patient group . Gemella is frequently reported as a member of the gastric microbiota in different cohorts, however, specific association between Bosea and atrophic gastritis was not reported in other studies.…”
Section: Resultsmentioning
confidence: 99%
“…It should be noted that when detected using conventional methods, H pylori comprises a significant proportion of the ecosystem often representing over 90% of bacteria. Reduced microbial diversity of the gastric microbiota and decreased abundance of other microbial groups is well documented in the case of H pylori colonisation . However, this seems to be a reversible situation.…”
Section: Resultsmentioning
confidence: 99%