2014
DOI: 10.1371/journal.pone.0114483
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Abstract: BackgroundFor the detection of malignant mesothelioma no single biomarker with reasonable sensitivity and specificity has been described so far. Mesothelin, the most prominent blood-based biomarker, is characterized by high specificity but low sensitivity. It might be reasonable to combine biomarkers of different molecular classes in order to improve the overall performance. The aim of this study was to assess the performance of the combination of mesothelin and miR-103a-3p as blood-based biomarker for mesothe… Show more

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Cited by 48 publications
(56 citation statements)
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References 35 publications
(47 reference statements)
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“…A recent study reported a better diagnostic performance for the combination of SMRP and carcinoembryonic antigen (CEA) compared to SMRP alone but this requires further validation in a multicenter study [166]. Some studies also suggested that a combination of mesothelin with markers from different molecular class, such as miRNA, can increase diagnostic performance more efficiently [139,167].…”
Section: Preventive Effects Of Iron Reduction On MMmentioning
confidence: 99%
“…A recent study reported a better diagnostic performance for the combination of SMRP and carcinoembryonic antigen (CEA) compared to SMRP alone but this requires further validation in a multicenter study [166]. Some studies also suggested that a combination of mesothelin with markers from different molecular class, such as miRNA, can increase diagnostic performance more efficiently [139,167].…”
Section: Preventive Effects Of Iron Reduction On MMmentioning
confidence: 99%
“…Weber et al (76) combined mesothelin and miR-103a-3p expression levels. Mesothelin concentration was evaluated in plasma, while miR-103a-3p in the cellular blood fraction.…”
Section: Combination Of Circulating Molecular Biomarkersmentioning
confidence: 99%
“…Several panels of biomarkers have been suggested as tools for screening and early diagnosis, clinical monitoring, prognosis and screening of MPM (60)(61)(62)(63)(64)(65)(66)(67)(68). The combinations studied are multiple: 80HdG, VEGFbeta and SMRPs (60), miR-126, in association with SMRPs (61), serum concentrations of SMRP, CA125, and CYFRA21-1 (62), combination of serum SMRP and pOPN (27), combination of SMRP and miR-103a-3p (63,64), SMRPs, miR-126 and methylated thrombomodulin promoter, Met-TM (65), fibulin-3 and SMRP (66), combination of miR-132-3 and miR-126 (48), combination of six biomarkers (SMRP-pOPN-IL6-vimentin-desmin-HGF) (56).…”
Section: Combination or Panel Of Serum Biomarkersmentioning
confidence: 99%