2009
DOI: 10.1371/journal.pcbi.1000352
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Abstract: Numerous studies are currently underway to characterize the microbial communities inhabiting our world. These studies aim to dramatically expand our understanding of the microbial biosphere and, more importantly, hope to reveal the secrets of the complex symbiotic relationship between us and our commensal bacterial microflora. An important prerequisite for such discoveries are computational tools that are able to rapidly and accurately compare large datasets generated from complex bacterial communities to iden… Show more

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Cited by 1,358 publications
(1,002 citation statements)
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References 37 publications
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“…A statistical method introduced in Metastats (http://cbcb.umd.edu/software/metastats) was used to reveal significant differences between the microbiota of control saliva and APS-1 saliva. This method employs a false discovery rate to improve specificity in high complexity environments, and handles sparsely sampled features using Fisher’s exact test [29]. p -values ≤ 0.05 were considered significant and Bonferonni Correction for multiple testing was included.…”
Section: Methodsmentioning
confidence: 99%
“…A statistical method introduced in Metastats (http://cbcb.umd.edu/software/metastats) was used to reveal significant differences between the microbiota of control saliva and APS-1 saliva. This method employs a false discovery rate to improve specificity in high complexity environments, and handles sparsely sampled features using Fisher’s exact test [29]. p -values ≤ 0.05 were considered significant and Bonferonni Correction for multiple testing was included.…”
Section: Methodsmentioning
confidence: 99%
“…To test the effect of heavy metal pollution on phyla structure, Matastats (White et al 2009) were used to conduct differentially abundant features between three groups (Table 3). Matastats results demonstrated that three groups have significant difference on Bacteroidetes, groups H and C have significant difference on Actinobacteria, and groups have no obvious difference on the other phyla.…”
Section: Correlation Between Community Structure and Environmental Famentioning
confidence: 99%
“…Analyses by OTU were performed using mothur, R (version 3.3.2) and metastats. 39 , 40 The samples were grouped according to disease status (active or inactive), smoking status, previous abdominal surgery, IBD subtype (CD or UC), medication use, disease duration, sampling technique (colonoscopy or resection) and examined for differentially abundant bacterial taxa using metastats within mothur. To reduce false discovery, OTUs were only included where they represented an average relative abundance > 0.1%.…”
Section: Methodsmentioning
confidence: 99%