Biologically active compounds from higher fungi

Steglich, Wölfgang

doi:10.1351/pac198153061233

Cited by 53 publications

(12 citation statements)

References 9 publications

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“…Fungi continue to provide active ingredients for important modern drugs, including statins and antifungal agents such as cyclosporine and echinocandin. It is therefore unsurprising that several publications have focused on the discovery of new active principles from fungi (Steglich 1981;Lorenzen and Anke 1998;Wasser 2002;Lindequist et al 2005). Many different chemical groups have been identified in fungi, including organic acids, polyynes, polyketides (such as quinones, anthraquinones, xanthones, etc.…”

Section: Introductionmentioning

confidence: 99%

Azaphilones: a class of fungal metabolites with diverse biological activities

2010

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This review presents an overview of azaphilones isolated from different species of fungi, detailing their chemical structures and biological activities as covered in the recent literature. Over 170 different azaphilone compounds occur in fungi belonging to 23 genera from 13 families: these azaphilones can be classified into ten different structural groups. Numerous azaphilone structures have been described, particularly from members of the Trichocomaceae and Xylariaceae families. Azaphilones exhibit a wide range of interesting biological activities, such as antimicrobial, antifungal, antiviral, antioxidant, cytotoxic, nematicidal and anti-inflammatory activities. Many of these effects may be explained by the reactions of azaphilones with amino groups, such as those found in amino acids, proteins and nucleic acids, resulting in the formation of vinylogous c-pyridones.

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Section: Introductionmentioning

confidence: 99%

Azaphilones: a class of fungal metabolites with diverse biological activities

2010

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“…In recent decades, pigments have attracted a great deal of research interest due to their exceptional biological roles (anti-oxidative, free radical killing, anti-carcinogenic, immunostimulation, protection against viruses and bacteria) [122,123]. Filamentous fungi are introduced as potential pigment producing microorganisms [124].…”

Section: Pigmentsmentioning

confidence: 99%

Use of Organic Wastes and Industrial By-Products to Produce Filamentous Fungi with Potential as Aqua-Feed Ingredients

et al. 2018

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Organic-rich waste and industrial by-product streams, generated in enormous amounts on a daily basis, contain substantial amounts of nutrients that are worthy of recovery. Biological conversion of organic-waste streams using filamentous fungi is a promising approach to convert nutrients into value-added bioproducts, such as fungal biomass. High-protein fungal biomass contains different kinds and levels of amino acids, fatty acids, immunostimulants, antioxidants, pigments, etc., which make it a potential choice for application in animal feed supplementation. Considering the challenges long faced by the aquaculture industry in fishmeal production due to the increasing prices and environmental concerns, the aquaculture industry is forced to provide alternative protein-rich sources to replace conventional fishmeal. In this review, the possibilities of utilization of filamentous fungi biomass cultivated on organic-rich waste streams, as an alternative nutrient source in fish feed, were thoroughly reviewed.

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“…Previous studies on the biosynthesis of boviquinone-4 (2) in S. bovinus revealed that the quinone ring is formed from 4-hydroxybenzoic acid (7) via 3,4-dihydroxybenzoic acid (8). [6,7] Rapid tautomerisation of the 2,5-dihydroxybenzoquinone 2 obtained after feeding the [1-13 C]-labeled precursors leads to an equal distribution of the label between positions 2 and 4.…”

Section: Previous Investigations On the Biosynthesis Of Suillus Merotmentioning

confidence: 99%

“…A boviquinone-4 epoxide was considered as plausible intermediate. [7,8] In order to obtain experimental proof for this suggestion, feeding experiments with 13 C-labeled precursors were carried out.…”

Section: Previous Investigations On the Biosynthesis Of Suillus Merotmentioning

confidence: 99%

Studies on the Structure and Biosynthesis of Tridentoquinone and Related Meroterpenoids from the Mushroom Suillus tridentinus (Boletales)

et al. 2008

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Tridentoquinone (1), the main pigment of Suillus tridentinus, is accompanied by the known meroterpenoid bolegrevilol (3) and a dimer, tridentorubin (5). The absolute configuration of 1 was unambiguously established by a single‐crystal X‐ray analysis of the corresponding (–)‐camphanoate. The structure of 5 was elucidated by 2D NMR techniques including a 2D INADEQUATE experiment. Feeding experiments with [1‐13C]‐labeled 4‐hydroxybenzoic acid (6*) and 3,4‐dihydroxybenzoic acid (7*) proved the incorporation of these precursors into all three metabolites. Tridentoquinone (1) was monolabeled at C‐1 suggesting the formation of the ansa ring by oxidative cyclisation of 2‐geranylgeranyl‐6‐hydroxybenzoquinone (10). This was supported by the isolation of the expected intermediate, deoxytridentoquinone (11), from the mushroom extract. Tridentorubin (5) may be formed by addition of precursor 10 to tridentoquinone (1). This hypothesis is backed up by the in vitro formation of an analogous product 13 from 1 and 1,4‐benzoquinone. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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Biologically active compounds from higher fungi

Cited by 53 publications

References 9 publications

Azaphilones: a class of fungal metabolites with diverse biological activities

Azaphilones: a class of fungal metabolites with diverse biological activities

Use of Organic Wastes and Industrial By-Products to Produce Filamentous Fungi with Potential as Aqua-Feed Ingredients

Studies on the Structure and Biosynthesis of Tridentoquinone and Related Meroterpenoids from the Mushroom Suillus tridentinus (Boletales)

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