Symposium on estrogens in the environment, III.

Multiple Stable Periodic Solutions in a Model for Hormonal Control of the Menstrual Cycle

“…McLachlan and Korach (1995) and Daston et al (1997) have suggested that the estrogenic activity of environmental substances may disrupt the sexual endocrine systems in both humans and animals. This activity may be contributing to the increased incidence of breast cancer (Davis et al, 1993), to declines in sperm counts (Sharpe and Skakkebaek, 1993), and to developmental abnormalities (McLachlan, 1985).…”

“…There is increasing concern that environmental substances with estrogenic activity may disrupt the sexual endocrine system in humans and animals, [e.g., see McLachlan and Korach (1995) or Daston et al (1997)]. The effects of exogenous estrogen on the dynamical behavior of our model may be tested by adding a term to the estrogen auxiliary equation (3a).…”

In vitro synergistic interaction of alligator and human estrogen receptors with combinations of environmental chemicals.

“…The presence of chemicals in the environment with hormonal or antihormonal activity has generated interest in understanding their potential for producing adverse health effects in wildlife and humans (1). To date, research concerning the capacity of individual chemicals to produce hormonal responses in cell culture or whole animal studies has been limited to concentrations that are higher than those generally measured in ecosystems.…”

Effects on Pharmaceuticals in the Environment — an Overview and Principle Considerations

“…Carbamazepine: An Example for Investigative Environmental Toxicology Using Mammalian Data the innovative publications of McLachlan directed the attention of the scientific community, the government and the public to this topic (McLachlan 1980(McLachlan ,1985(McLachlan , 1993McLachlan et al 1984McLachlan and Newbold 1987;McLachlan and Korach 1995). Subsequently, varying and sometimes contradictory information became available dealing with different aspects of endocrine modulation.…”