Phenolic Constituents of Licorice. III. Structures of Glicoricone and Licofuranone, and Inhibitory Effects of Licorice Constituents on Monoamine Oxidase.

Hatano, Tsutomu; Fukuda, Takuya; Miyase, Toshio; Noro, Tadataka; Okuda, Takuo

doi:10.1248/cpb.39.1238

Cited by 51 publications

(25 citation statements)

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“…Antidepressant-like effect of liquorice extract might be through the restoration of brain monoamines, like norepinephrine and dopamine levels. Glycyrrhizin, the main constituent of liquorice, showed MAO inhibiting activity [30,31]. Aqueous extract of Glycyrrhiza glabra was also depicted to increase animal resistance to stress and play a role for adaptogenic activity.…”

Section: Fementioning

confidence: 98%

Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review

Thakur¹,

Raj²

2017

JAPLR

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The Glycyrrhiza genus contains more than 30 species and widely distributed all over the world [7]. Glycyrrhiza genus plants are wide spread in Mediterranean, Southern and Central Russia and Asia, being minor to Iran. Many species are now grown throughout Europe, Syria, Asia, UK, USA, Italy, France, Germany, AbstractGlycyrrhiza glabra Linn. (Family: Fabaceae) is a traditional medicinal plant used in various ancient medicine systems and documented across the globe for its ethanopharmacological value to cure varieties of ailments. Glycyrrhizin is the major active constituent obtained from liquorice roots, one of the most widely used in herbal preparations for the treatment and management of chronic diseases. The present mini-review is focused mainly on major secondary metabolites, ethnopharmacology and potential medicinal uses of Glycyrrhiza glabra. The sources for the literature search were PubMed, ScienceDirect, SciFinder and Google Scholar. Reported pharmacological activities, characterized secondary metabolites and traditional uses of Glycyrrhiza glabra warrants its potential therapeutic uses. However, further scientific validations along with evidencebased studies are still required in support to its traditional uses, to serve as "lead" for development of novel agents and a better drug candidate in future. Keywords:

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Section: Fementioning

confidence: 98%

Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review

Thakur¹,

Raj²

2017

JAPLR

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“…Our investigation of licorice constituents revealed the inhibitory effects of flavonoids, including new ones, on xanthine oxidase [28] and monoamine oxidase [29]. Several also effective against the cytopathic effects of human immunodeficiency virus (HIV).…”

Section: Flavonoids and 3-arylcoumarins From Licoricementioning

confidence: 99%

Herbal Drugs in Traditional Japanese Medicine

Hatano¹

2012

Alternative Medicine

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“…Thus, centrifugal partition chromatography (CPC) and droplet countercurrent chromatography (DCCC), which were devised as efective methods for CCD, in addition to simple CCD using separatory funnels, were applied to purify the licorice phenolics in our studies. The solvent system chloroform-methanol-water (7:13:8, by volume) was primarily used for the separation of licorice phenolics derived from Glycyrrhiza inlata [9,10] and those derived from G. uralensis [11][12][13][14][15][16] in these CCD processes. Combinations of column chromatography on a silica gel, ODS-gel, and/or polystyrene gel (MCI-gel CHP-20P) with CCD also aforded satisfactory separation [17,18].…”

Section: Puriication Of Licorice Phenolicsmentioning

confidence: 99%

Licorice as a Resource for Pharmacologically Active Phenolic Substances: Antioxidant and Antimicrobial Effects

Hatano¹,

Eerdunbayaer²,

Cui³

et al. 2017

Biological Activities and Action Mechanisms of Licorice Ingredients

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The indings from our studies on licorice phenolics are summarized here. The following types of lavonoids, i.e., lavones, lavonols, lavanones, chalcones, isolavones, isolavanones, isolavans, 3-arylcoumarins, coumestans, pterocarpans, 2-benzyldihydrobenzofuran-3-ones, benzyl phenyl ketones, 2-arylbenzofurans, and others, were identiied by the structural studies. Among them, licochalcone A (chalcone), isolicolavonol (lavonol), glycycoumarin (3-arylcoumarin), and glycyrrhisolavone (isolavone) displayed antihuman immunodeiciency virus efects, and also 8-(γ,γ-dimethylallyl)-wighteone (isolavone) and 3′-(γ,γ-dimethylallyl)-kievitone (isolavanone) showed potent antibacterial efects on methicillin-resistant Staphylococcus aureus (MRSA) strains. Licoricidin (isolavan) suppressed the oxacillin resistance of the MRSA strains noticeably. Efects of phenolics with related structures isolated from Psoralea corylifolia were also examined, and bakuchiol (meroterpene), isobavachalcone, and corylifol B (chalcones) also showed potent efects on MRSA strains. Some licorice phenolics such as licoricidin (isolavan), 8-(γ,γ-dimethylallyl)-wighteone (isolavone), and gancaonin I (2-arylbenzofuran) also showed potent antibacterial efects on vancomycin-resistant Enterococcus (VRE) strains. The potency of the efects largely depended on their structures including the lipophilic prenyl or related substituents and also phenolic hydroxyl groups. Inhibitory efects of licorice phenolics on oxidative enzymes, in addition to their radical-scavenging efects, are also shown. The methods used in the structural studies and high-performance liquid chromatographic analysis of licorice extracts are described shortly, too.

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Phenolic Constituents of Licorice. III. Structures of Glicoricone and Licofuranone, and Inhibitory Effects of Licorice Constituents on Monoamine Oxidase.

Cited by 51 publications

References 1 publication

Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review

Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review

Herbal Drugs in Traditional Japanese Medicine

Licorice as a Resource for Pharmacologically Active Phenolic Substances: Antioxidant and Antimicrobial Effects

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