Treatment of solitary autonomous thyroid nodules by percutaneous ethanol injection: results of an Italian multicenter study. The Multicenter Study Group.

“…The results of an Italian multicenter trial were published in 1996 (6). In this large series, 429 patients with solitary autonomous nodules treated with PEI were followed for 12 months (242 toxic adenomas, 187 autonomous adenomas).…”

Section: Discussionmentioning

confidence: 99%

Treatment of autonomous and toxic thyroid adenomas by percutaneous ultrasound-guided ethanol injection

Brkljačić¹,

Sučić

Božikov

et al. 2001

Acta Radiologica

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“…The available modalities currently are long‐term anti‐thyroidal medication, radioactive iodine ablation, and surgical excision. Recent reports have suggested the use of ultrasound‐guided percutaneous ethanol injection as a safe method for the treatment of hyperfunctioning thyroid nodules 8,9 …”

Section: Discussionmentioning

confidence: 99%

Management of hyperfunctioning single thyroid nodules in the era of minimally invasive thyroid surgery

Tan

Sidhu

Sywak

et al. 2009

ANZ Journal of Surgery

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Both surgical excision and radioiodine ablation are effective modalities in the management of hyperfunctioning thyroid nodules. Minimally invasive thyroid surgery (MITS) using the lateral mini-incision approach has previously been demonstrated to be a safe and effective technique for thyroid lobectomy. As such MITS may offer advantages as a surgical approach to hyperfunctioning thyroid nodules without the need for a long cervical incision or extensive dissection associated with formal open hemithyroidectomy. The aim of the present study was to assess the safety and efficacy of MITS for the treatment of hyperfunctioning thyroid nodules. This is a retrospective case study. Data were obtained from the University of Sydney Endocrine Surgical Unit Database from 2002 to 2007. There were 86 cases of hyperfunctioning thyroid nodules surgically removed during the study period, of which 10 (12%) were managed using the MITS approach. The ipsilateral recurrent laryngeal nerve was identified and preserved in all cases with no incidence of temporary or permanent nerve palsy. The external branch of the superior laryngeal nerve was visualized and preserved in eight cases (80%). There were no cases of postoperative bleeding. There was one clinically significant follicular thyroid carcinoma in the series (10%). In nine of 10 cases (90%) normalization of thyroid function followed surgery. MITS is a safe and effective procedure, achieving the benefits of a minimally invasive procedure with minimal morbidity. As such it now presents an attractive alternative to radioiodine ablation for the management of small hyperfunctioning thyroid nodules.

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“…In addition, shrinkage of nodular volume always occurred, being independent of the effects on thyroid function. 1,11,24 Among the various aspects and factors that affect the success of PEI, the experience of the operator is recognized as one of the most relevant in determining PEI outcome, 21 but the relevance of the type of ultrasonographic technique employed should not be underestimated. The introduction of CDUS technique gave us the possibility of performing a morphologic and a functional study of AFTN, based on the observation that these nodules are characterized by a higher vascularization, both in the peripheral area and inside the nodule, than in the remaining parenchyma.…”

Section: Discussionmentioning

confidence: 99%

Power Doppler ultrasonographic assistance in percutaneous ethanol injection of autonomously functioning thyroid nodules.

Spiezia

Cerbone

Assanti

et al. 2000

Journal of Ultrasound in Medicine

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ltrasonographically guided PEI is considered a good alternative tool in the treatment of AFTN, leading to normalization of thyroid hormone levels, to recovery of extranodular tracer uptake, and to reduction of nodular volume.From 1990, when it was first proposed by Livraghi and coworkers 1 until the present, many studies have confirmed the safety and usefulness of PEI in treating AFTN; in these studies, PEI achieved complete cure in 68 to 100% of PTA and in 50 to 89% of TA, whereas partial cure (such as normalization of thyroid hormone levels with still undetectable TSH levels and scintigraphic partial reactivation of extranodular uptake) was obtained in 0 to 39% of PTA and TA. Nodular shrinkage was recorded in all cases. [2][3][4][5][6][7][8][9][10][11][12] In all these reports, however, the procedure was performed under B-mode or CDUS guidance. In particular, the introduction of CDUS technique was based on the observation that hyperfunctioning thyroid nodules are characterized by high vascularization either peripherally or within the nodule. [12][13][14] Recently, a new CDUS technique, PDUS, has been

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Treatment of solitary autonomous thyroid nodules by percutaneous ethanol injection: results of an Italian multicenter study. The Multicenter Study Group.

Cited by 38 publications

References 20 publications

Treatment of autonomous and toxic thyroid adenomas by percutaneous ultrasound-guided ethanol injection

Treatment of autonomous and toxic thyroid adenomas by percutaneous ultrasound-guided ethanol injection

Management of hyperfunctioning single thyroid nodules in the era of minimally invasive thyroid surgery

Power Doppler ultrasonographic assistance in percutaneous ethanol injection of autonomously functioning thyroid nodules.

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