1986
DOI: 10.1210/endo-119-1-292
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Abstract: A presumptive mitochondrial T3 receptor previously reported from this and other laboratories appears capable of accounting for the activation of liver mitochondrial oxidative phosphorylation within 30 min after iv bolus injection of nanogram doses of T3 into hypothyroid rats. The inner mitochondrial membrane carrier adenine nucleotide translocase (AdNT) catalyzes the exchange between the extra- and intramitochondrial ADP and ATP, and has been shown by measurements of flux control coefficients to exert a signif… Show more

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Cited by 95 publications
(31 citation statements)
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“…These data led to the proposition that ANT was a major T3 target involved in the short-term influence of the hormone on the organelle. In agreement with this hypothesis, Sterling (1986) reported that ANT is a high-affinity binding site for T3. However, despite the availability of the purified protein and related antibodies or expression vectors, this last result has not received any confirmation.…”
Section: Short-term Influencesupporting
confidence: 64%
“…These data led to the proposition that ANT was a major T3 target involved in the short-term influence of the hormone on the organelle. In agreement with this hypothesis, Sterling (1986) reported that ANT is a high-affinity binding site for T3. However, despite the availability of the purified protein and related antibodies or expression vectors, this last result has not received any confirmation.…”
Section: Short-term Influencesupporting
confidence: 64%
“…However, deficiency in direct T 3 stimulation of ADP/ ATP exchange could explain in part the increase in ADP associated with epinephrine infusion in the thyroidectomized sheep. This consideration stems from reports from several research groups identifying specific T 3 -binding activity in the inner mitochondrial membrane in association with rapid T 3 enhancement of ADP/ATP exchange efficiency (27,42,48,49 (27) demonstrated that reduced ADP/ATP exchange efficiency in liver mitochondria isolated under hypothyroid conditions can be normalized to euthyroid levels within 15 min of T 3 exposure provided either in vivo or in vitro. The precise mechanism for immediate T 3 action on liver mitochondria ANT remains controversial, but some studies implicate T 3 allosteric modification of an ADP-ribosyl transferase, which covalently modifies ANT, as opposed to direct T 3 binding to ANT (27).…”
Section: Discussionmentioning
confidence: 99%
“…Our data showing regulation of all the mitochondrial transcripts tested, together with the lack of differences in the mtDNA content between control and hypothyroid neonates, strongly suggest an effect of thyroid hormone on mitochondrial transcription and/or RNA stabilization. Mitochondrial binding sites for thyroid hormone have been postulated since 1975 (42,43), and different proteins have been suggested to be the mitochondrial T3 receptor (44). However, the specificity of these mitochondrial binding sites has been questioned since then, and specific binding of thyroid hormone to the mitochondria appears to be very questionable.…”
Section: Discussionmentioning
confidence: 99%