Bioactive Compounds from Natural Sources

Tringali, Corrado

doi:10.1201/9781482289268

Cited by 33 publications

(16 citation statements)

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“…Compounds containing macrocyclic rings as well as furan derivatives are quite common and are often biologically active. 45,183 Phyllostictine A was further studied to develop a rapid analytical method to estimate phyllostictine A content in culture preparations and to assess the phytotoxic effect for potential weed control. 184…”

Section: Phytotoxins Produced By Phyllosticta Cirsiimentioning

confidence: 99%

Relationships between the stereochemistry and biological activity of fungal phytotoxins

2011

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Toxins produced by phytopathogenic fungi assume great importance because of their involvement in several plant diseases. Although such pathogens are known to have seriously damaged crops, forest, and environmental resources, they represent a very important tool to develop new environmentally friendly herbicides and fungicides. This review deals with the relationships between the biological activity of some phytotoxins produced by pathogenic fungi for major forest plants and for damaging weeds and their stereochemistry. In particular, the methods used to determine their relative and/or absolute configuration will be illustrated. These include the application of Mosher's and Murata's methods, X-ray diffractometric analysis, circular dichroism, and the use of computational methods to determine the theoretical optical rotatory power as well as the CD spectrum. The importance of determining the absolute configuration to achieve the total synthesis of some phytotoxins, interesting for their potential practical application, is also discussed.

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Section: Phytotoxins Produced By Phyllosticta Cirsiimentioning

confidence: 99%

Relationships between the stereochemistry and biological activity of fungal phytotoxins

2011

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“…Now, however, there is a resurgence of interest in natural product based discoveries. These compounds are now finding world-wide interest because of their low toxicity, their complete biodegradability, their availability from renewable sources, and, in most cases, their low cost when compared with those of compounds obtained by total chemical synthesis [31]. Certainly, one source of novel bioactive natural products is the world's endophytes and the report on taxol, described above, was a key example.…”

Section: The Complexities Of the Host-endophyte Relationshipmentioning

confidence: 99%

Chemical and Functional Diversity of Natural Products from Plant Associated Endophytic Fungi

Verma

Kharwar

Strobel

2009

Natural Product Communications

123

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“…Many natural products found in plants are potential therapeutic agents to be used in a wide range of pathologies. 1 Phytochemicals include compounds with various biological properties, which have possibly evolved to allow plants to cope with environmental challenges, including exposure to radiation and toxins and defense against pests and infectious agents. Among phytochemicals, phenolic compounds, and in particular those found in food plants, have received particular attention in past years, in particular as antioxidant and cancer chemopreventive agents.…”

Section: Introductionmentioning

confidence: 99%

Effects of a Ferulate-Derived Dihydrobenzofuran Neolignan on Angiogenesis, Steroidogenesis, and Redox Status in a Swine Cell Model

et al. 2014

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In the ongoing search for new therapeutic compounds, lignans and neolignans, which are widely distributed in plants, deserve special attention because of their interactions with several biological targets. Searching for potential antiangiogenic agents related to natural lignans/neolignans, we were attracted by a previously studied synthetic dihydrobenzofuran neolignan. We synthesized the compound by means of an eco-friendly, enzyme-mediated biomimetic coupling of the methyl ester of ferulic acid, and the present study was aimed to deeply investigate its effect in angiogenesis bioassays validated in our laboratory. In addition, a previously well-defined granulosa cell model was employed to evaluate the effect of dihydrobenzofuran neolignan on cell viability, steroidogenesis, and redox status. Present data support the antiangiogenic effect of this neolignan. Moreover, we demonstrate that, at least at the highest concentrations tested, dihydrobenzofuran neolignan affects granulosa cell viability and steroidogenesis. In addition, the compound inhibits generation of free radicals and stimulates scavenger enzyme activities. The present data, which are a further deepening of the evaluation of the biological activities of the dihydrobenzofuran lignan in well-defined cell models, are of interest and worthy of special attention.

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Bioactive Compounds from Natural Sources

Cited by 33 publications

References 0 publications

Relationships between the stereochemistry and biological activity of fungal phytotoxins

Relationships between the stereochemistry and biological activity of fungal phytotoxins

Chemical and Functional Diversity of Natural Products from Plant Associated Endophytic Fungi

Effects of a Ferulate-Derived Dihydrobenzofuran Neolignan on Angiogenesis, Steroidogenesis, and Redox Status in a Swine Cell Model

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