Hand strenght and dexterity in interphalangeal hand osteoarthritis and effects of osteophyte formations

Guven, N.; Dinçer, Fitnat; Çetin, Alp; Güven, Serdar Can

doi:10.1186/s42358-020-00143-7

Cited by 4 publications

(2 citation statements)

References 28 publications

(44 reference statements)

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“…Osteoarthritis is the most common form of hand arthritis. It is a complex disorder that can be characterized in several subtypes such as interphalangeal arthrosis, nodular arthritis, erosive arthritis, and arthritis of the carpometacarpal joint of the thumb, or rhizarthrosis [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Translation and cross-cultural adaptation of “Trapeziometacarpal Arthrosis Symptoms and Disability—TASD” into Brazilian Portuguese

et al. 2021

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Background Osteoarthritis is the most common form of hand arthritis and arthritis of the carpometacarpal joint of the thumb is a potentially limiting disease. There is no homogeneity in the evaluation of outcomes for the rhizarthrosis treatment. In an attempt to standardize the evaluation of results, some subjective questionnaires, non-specific, were used to evaluate rhizarthrosis. Trapeziometacarpal Arthrosis Symptoms and Disability (TASD) was described by Becker et al.with the purpose of evaluating symptom intensity and degree of disability, as to compare results after treatment. Our objective is to translate, validate and do the cultural adaptation of the questionnaire TASD into the Brazilian Portuguese. Methods The questionnaire was translated, with reverse translation. The translations were evaluated and synthesized by a committee, arriving at TASD-BR. Thirty-one patients with a diagnosis of rhizarthrosis answered the questionnaire. We evaluated, the internal consistency, reliability, agreement and ceiling and floor effect for validation. Results The questionnaires were translated and adapted according to defined protocols. The internal consistency, through Cronbach's α coefficient for TASD-BR, was 0.927. The questionnaire's reliability, through the Intraclass Correlation Coefficient, was also shown to be quite high, with κ = 0.961 (0.954–0.967). The agreement, measured through the Standard Error Measurement, remained with standardized values below 5%. There was no ceiling and floor effect. Conclusion Through specific methodology we consider TASD-BR translated and valid for the Brazilian Portuguese.

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Section: Introductionmentioning

confidence: 99%

“…Radiographic variation or ultrasound exams showing joint degeneration may not correspond to functional or inflammatory limitations. This can disturb the management and the indications of treatment [1,6].…”

Section: Introductionmentioning

confidence: 99%

Translation and cross-cultural adaptation of “Trapeziometacarpal Arthrosis Symptoms and Disability—TASD” into Brazilian Portuguese

et al. 2021

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Subluxation of the first carpometacarpal joint and age are important factors in reduced hand strength in patients with hand osteoarthritis

Beest

Kloppenburg

Rosendaal

et al. 2023

Scandinavian Journal of Rheumatology

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Synovial osteoclastogenesis mediated by chondrocyte‐secreted TNFα promotes TMJ condylar resorption

Xiao,

Ran,

Xuemin

et al. 2024

Oral Diseases

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BackgroundInsufficient occlusal support (IOS) frequently causes subchondral bone absorption in temporomandibular joint osteoarthritis, and the underlying mechanism requires further investigation.MethodsAn IOS model was established by abrading rat molars. Micro‐computed tomography was used to evaluate subchondral bone changes. Osteoclastogenesis of synovium‐derived macrophages (SDMs) was confirmed by TRAP staining. Cartilage‐specific TNFα depletion was achieved by intra‐articular injection of adeno‐associated virus carrying shRNA against murine TNFα under control of collagen type II. In vitro, chondrocytes were mechanically compressed and conditioned medium (CM) was collected to detect its ability to induce osteoclastogenesis of SDMs.ResultsSynovial osteoclastogenesis and condyle resorption were observed following IOS. TNFα level was elevated in hypertrophic chondrocytes after IOS. Synovial Wnt5a level increased, but Wnt3a level decreased after IOS. Depletion of TNFα in chondrocytes alleviated the synovial osteoclastogenesis and condyle bone resorption. In vitro compression of chondrocytes potentiated TNFα expression and secretion. The CM promoted osteoclastogenesis of SDMs, which were partially prohibited by TNFα neutralizing antibody. Furthermore, inhibition of Wnt3a facilitated osteoclastogenesis, whereas inhibition of Wnt5a partially suppressed osteoclastogenesis, of SDMs cultured in CM.ConclusionChondrocyte‐secreted TNFα induced by IOS is a critical regulator of synovial osteoclastogenesis and subsequent condylar resorption, partially through non‐canonical Wnt5a pathway.

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Hand strenght and dexterity in interphalangeal hand osteoarthritis and effects of osteophyte formations

Cited by 4 publications

References 28 publications

Translation and cross-cultural adaptation of “Trapeziometacarpal Arthrosis Symptoms and Disability—TASD” into Brazilian Portuguese

Translation and cross-cultural adaptation of “Trapeziometacarpal Arthrosis Symptoms and Disability—TASD” into Brazilian Portuguese

Subluxation of the first carpometacarpal joint and age are important factors in reduced hand strength in patients with hand osteoarthritis

Synovial osteoclastogenesis mediated by chondrocyte‐secreted TNFα promotes TMJ condylar resorption

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