Genetic control of iron bioavailability is independent from iron concentration in a diverse winter wheat mapping population

Wright, Tally I.C.; Gardner, Keith A.; Glahn, Raymond P.; Milner, Matthew J.

doi:10.1186/s12870-021-02996-6

Cited by 7 publications

(5 citation statements)

References 47 publications

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“…Additional small genetic effects may explain the remaining heritability but were not detected using the statistical power available in this study. Wright et al ( 2021 ) investigated similar traits in the same population with a similar number of lines and found that the probability of detecting small effect QTL (explaining <10% of the variation) was very low, unless the trait heritability was very high. We acknowledge that low heritability of some traits and testing in only two trial years may limit the extent to which results can be interpreted.…”

Section: Discussionmentioning

confidence: 99%

Trade-offs in the genetic control of functional and nutritional quality traits in UK winter wheat

Fradgley

Gardner

Kerton³

et al. 2022

Heredity

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A complex network of trade-offs exists between wheat quality and nutritional traits. We investigated the correlated relationships among several milling and baking traits as well as mineral density in refined white and whole grain flour. Our aim was to determine their pleiotropic genetic control in a multi-parent population over two trial years with direct application to practical breeding. Co-location of major quantitative trait loci (QTL) and principal component based multi-trait QTL mapping increased the power to detect QTL and revealed pleiotropic effects explaining many complementary and antagonistic trait relationships. High molecular weight glutenin subunit genes explained much of the heritable variation in important dough rheology traits, although additional QTL were detected. Several QTL, including one linked to the TaGW2 gene, controlled grain size and increased flour extraction rate. The semi-dwarf Rht-D1b allele had a positive effect on Hagberg falling number, but reduced grain size, specific weight, grain protein content and flour water absorption. Mineral nutrient concentrations were lower in Rht-D1b lines for many elements, in wholemeal and white flour, but potassium concentration was higher in Rht-D1b lines. The presence of awns increased calcium content without decreasing extraction rate, despite the negative correlation between these traits. QTL were also found that affect the relative concentrations of key mineral nutrients compared to phosphorus which may help increase bioavailability without associated anti-nutritional effects of phytic acid. Taken together these results demonstrate the potential for marker-based selection to optimise trait trade-offs and enhance wheat nutritional value by considering pleiotropic genetic effects across multiple traits.

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Section: Discussionmentioning

confidence: 99%

Trade-offs in the genetic control of functional and nutritional quality traits in UK winter wheat

Fradgley

Gardner

Kerton³

et al. 2022

Heredity

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“…While future research is required to determine whether elevated levels of phenolics that stimulate and inhibit Fe uptake in the human gut can help alleviate the anaemia seen in Ethiopian children [ 67 ], the significance of the SNP in the tef F3’H gene Et_s3159-0.29-1.mrna1, which explains a large proportion of the variation in kaempferol glycoside and quercetin glycoside levels, suggest this might be a breeding target to improve Fe bioavailability in tef, as kaempferol glycoside is known to promote Fe absorption while quercetin glycoside inhibits Fe absorption in cell assays [ 60 ]. In addition, phenolic compounds have also been found to influence other agronomic traits, including tolerance to both biotic and abiotic stress [ 16 , 60 , 61 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recent advancements in our understanding of the genetics of tef include a fairly complete genome assembly, the release of gene models, as well as a number of RNASeq datasets which are all publicly available [ 11 ] . These allow for translation of knowledge on grain fortification from other species, supporting more rapid advancements in efforts to improve the nutritional potential of tef [ 12 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Nutritional and genetic variation in a core set of Ethiopian Tef (Eragrostis tef) varieties

et al. 2022

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Background Tef (Eragrostis tef) is a tropical cereal domesticated and grown in the Ethiopian highlands, where it has been a staple food of Ethiopians for many centuries. Food insecurity and nutrient deficiencies are major problems in the country, so breeding for enhanced nutritional traits, such as Zn content, could help to alleviate problems with malnutrition. Results To understand the breeding potential of nutritional traits in tef a core set of 24 varieties were sequenced and their mineral content, levels of phytate and protein, as well as a number of nutritionally valuable phenolic compounds measured in grain. Significant variation in all these traits was found between varieties. Genome wide sequencing of the 24 tef varieties revealed 3,193,582 unique SNPs and 897,272 unique INDELs relative to the tef reference var. Dabbi. Sequence analysis of two key transporter families involved in the uptake and transport of Zn by the plant led to the identification of 32 Zinc Iron Permease (ZIP) transporters and 14 Heavy Metal Associated (HMA) transporters in tef. Further analysis identified numerous variants, of which 14.6% of EtZIP and 12.4% of EtHMA variants were non-synonymous changes. Analysis of a key enzyme in flavanol synthesis, flavonoid 3′-hydroxylase (F3’H), identified a T-G variant in the tef homologue Et_s3159-0.29-1.mrna1 that was associated with the differences observed in kaempferol glycoside and quercetin glycoside levels. Conclusion Wide genetic and phenotypic variation was found in 24 Ethiopian tef varieties which would allow for breeding gains in many nutritional traits of importance to human health.

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“…Yet, increasing Fe content in wheat seeds seems to not correlate with higher Fe bioavailability and the underlying genetic regions controlling Fe content not found, yet, to colocalize with increased Fe absorption. In addition, phytate content also does not correlate with Fe bioavailability, leading to the conclusion that phytate binding may be insufficient to explain the lack of correlation between Fe bioavailability and Fe content ( Wright et al., 2021 ). All these observations give hope that Fe content and bioavailability are independent and feasible to integrate the two traits simultaneously.…”

Section: Nutrient Profiling Spatial and Temporal Distribution And Acc...mentioning

confidence: 99%

Biofortification to avoid malnutrition in humans in a changing climate: Enhancing micronutrient bioavailability in seed, tuber, and storage roots

Dwivedi¹,

Garcia‐Oliveira

Govindaraj

et al. 2023

Front. Plant Sci.

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Malnutrition results in enormous socio-economic costs to the individual, their community, and the nation’s economy. The evidence suggests an overall negative impact of climate change on the agricultural productivity and nutritional quality of food crops. Producing more food with better nutritional quality, which is feasible, should be prioritized in crop improvement programs. Biofortification refers to developing micronutrient -dense cultivars through crossbreeding or genetic engineering. This review provides updates on nutrient acquisition, transport, and storage in plant organs; the cross-talk between macro- and micronutrients transport and signaling; nutrient profiling and spatial and temporal distribution; the putative and functionally characterized genes/single-nucleotide polymorphisms associated with Fe, Zn, and β-carotene; and global efforts to breed nutrient-dense crops and map adoption of such crops globally. This article also includes an overview on the bioavailability, bioaccessibility, and bioactivity of nutrients as well as the molecular basis of nutrient transport and absorption in human. Over 400 minerals (Fe, Zn) and provitamin A-rich cultivars have been released in the Global South. Approximately 4.6 million households currently cultivate Zn-rich rice and wheat, while ~3 million households in sub-Saharan Africa and Latin America benefit from Fe-rich beans, and 2.6 million people in sub-Saharan Africa and Brazil eat provitamin A-rich cassava. Furthermore, nutrient profiles can be improved through genetic engineering in an agronomically acceptable genetic background. The development of “Golden Rice” and provitamin A-rich dessert bananas and subsequent transfer of this trait into locally adapted cultivars are evident, with no significant change in nutritional profile, except for the trait incorporated. A greater understanding of nutrient transport and absorption may lead to the development of diet therapy for the betterment of human health.

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Genetic control of iron bioavailability is independent from iron concentration in a diverse winter wheat mapping population

Cited by 7 publications

References 47 publications

Trade-offs in the genetic control of functional and nutritional quality traits in UK winter wheat

Trade-offs in the genetic control of functional and nutritional quality traits in UK winter wheat

Nutritional and genetic variation in a core set of Ethiopian Tef (Eragrostis tef) varieties

Biofortification to avoid malnutrition in humans in a changing climate: Enhancing micronutrient bioavailability in seed, tuber, and storage roots

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