2011
DOI: 10.1186/gb-2010-11-12-219
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Abstract: Recent research shows that short RNA molecules act as mobile signals that direct mRNA cleavage and DNA methylation in recipient cells.

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Cited by 118 publications
(83 citation statements)
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“…Like other monopartite closteroviruses, it is likely that GLRaVs encode a single or multiple VSRs with distinct modes of action by targeting the antiviral pathway at multiple steps, as shown with CTV (86). Growing evidence suggests short-and long-distance movement of all known size classes of sRNAs, and they ferry silencing signals in the phloem to act over long-distance gene regulation in recipient cells (25,97). Additionally, some viral-encoded movement proteins act as viral enhancers of RNA silencing to potentiate phloem-mediated spread of virus-induced host sRNAs and virus-encoded vsRNAs (12), indicating the biological significance of systemic silencing signals in virus-host interactions and pathogenesis.…”
Section: Suppressors Of Rna Silencingmentioning
confidence: 96%
“…Like other monopartite closteroviruses, it is likely that GLRaVs encode a single or multiple VSRs with distinct modes of action by targeting the antiviral pathway at multiple steps, as shown with CTV (86). Growing evidence suggests short-and long-distance movement of all known size classes of sRNAs, and they ferry silencing signals in the phloem to act over long-distance gene regulation in recipient cells (25,97). Additionally, some viral-encoded movement proteins act as viral enhancers of RNA silencing to potentiate phloem-mediated spread of virus-induced host sRNAs and virus-encoded vsRNAs (12), indicating the biological significance of systemic silencing signals in virus-host interactions and pathogenesis.…”
Section: Suppressors Of Rna Silencingmentioning
confidence: 96%
“…Transport of sRNA between plant cells and their role in the cell differentiation or in the response to the viruses infection is well understood (for a review see refs. 54,55). One of the best documented examples is the description of 2 microRNA molecules: miR165a and miR166b, involved in the development of vascular tissue in Arabidopsis thaliana root 56 , 57 .…”
Section: Symplasmic Transport—route For Molecules Including Macromoleculesmentioning
confidence: 99%
“…Amplification of RNA silencing has been implicated in the spread of an RNA silencing signal (Kalantidis et al 2008;Molnar et al 2010Molnar et al , 2011Schwach et al 2005). Small RNAs of 21-24 nt lengths generated during cell-autonomous RNA silencing spread from the site of initiation to the neighboring cells through plasmodesmata.…”
Section: Systemic Silencingmentioning
confidence: 99%