Predictors of disease progression in HIV infection: a review

Langford, Simone; Ananworanich, Jintanat; Cooper, David A.

doi:10.1186/1742-6405-4-11

Cited by 250 publications

(239 citation statements)

References 144 publications

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“…Many studies have pointed out that single point estimation of CD4 + T lymphocyte counts cannot always be accepted alone as a reliable predictor for disease progression in HIV-1 infection [33] [34]. In our previous study on HIV-1 positive children, baseline CD4 + T lymphocyte count could not be correlated with disease progression and rate of decline of CD4+ T lymphocyte counts was found to be more reliable predictor of future course of illness which is in agreement with the findings of negative correlation between the rate of fall in CD4 + T lymphocyte count with the disease progression in the subgroup of HIV-1 positive donors with history of oral iron intake [17].…”

Section: Discussionmentioning

confidence: 99%

High Incidence of Pulmonary Tuberculosis in ART Naive Remunerated Blood Donors with Human Immunodeficiency Virus Type-1 Infection: Possible Role of Iron Overload

Chattopadhya¹,

Baveja²

2018

JBM

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Iron overload is reported to be associated with immune alterations and increased susceptibility to infections. HIV infection is characterized by progressive immunodeficiency leading to invasion by opportunistic pathogens. It was of interest to find out if disease course in HIV type-1 infection could have any relation with alteration in body iron status among individuals with history of oral iron intake. A follow-up study of immunologic and virologic markers in relation to disease progression was undertaken on asymptomatic HIV-1 positive blood donors with history of oral iron intake (subgroup I) compared to those without such history (subgroup II). High serum iron was associated with elevated levels of Th 2 category of cytokines, heightened immune activation, faster decline in CD4 + T lymphocyte count and higher viral set point. Pulmonary tuberculosis (PT) was the most common AIDS related illness (ARI) (>70%) recorded among subgroup I compared to non-PT category of ARI. Median ARI free duration (months) was shorter among those who developed PT compared to those developing non-PT category of ARI i.e. 30 (95% CI as 26,32) versus 67(95% CI as 60,71) in subgroup I and 47 (95% CI as 42,49) versus 80 (95% CI as 72,87) in subgroup II (P < 0.001 for PT versus non-PT in both subgroups). Median survival duration (months) in the PT versus non-PT categories of ARI was 47 (95% CI as 42,48) versus 95 (95% CI as 90,100) in subgroup I and 71 (95% CI as 65,76) versus 107 (95% CI as 102,112) in subgroup II (P < 0.001 for PT versus non-PT in both subgroups). The present study indicates that body iron overload resulting from excess intake of iron may be associated with qualitative defects in cell mediated im-

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Section: Discussionmentioning

confidence: 99%

High Incidence of Pulmonary Tuberculosis in ART Naive Remunerated Blood Donors with Human Immunodeficiency Virus Type-1 Infection: Possible Role of Iron Overload

Chattopadhya¹,

Baveja²

2018

JBM

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“…A infecção assintomática caracteriza-se por sintomas clínicos míni-mos (como, por exemplo, linfadenopatia generalizada persistente) ou inexistentes, iniciando no 6 o mês de infecção e se estendendo em média de cinco a nove anos, que culmina com a pessoa estando sintomática ou laboratorialmente doente. Nessa fase, o tecido linfoide atua como o maior reservatório de HIV do organismo, porém, com a evolução da infecção ocorre a sua lenta e progressiva diminuição e, como, consequência, o vírus novamente é liberado na corrente sanguínea, aumentando a viremia plasmática (1,2,44,48,49) . Reitera-se que o T CD4+ é o marcador prognóstico da AIDS e da sobrevivência do indivíduo infectado pelo HIV (50) .…”

Section: ) Hiv/aids: Da Infecção à Tarvunclassified

HIV/AIDS e Treinamento Concorrente: a Revisão Sistemática

Lazzarotto¹,

Deresz²,

Sprinz³

2010

Rev Bras Med Esporte

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RESUMOO uso da terapia anti-retroviral combinada (TARV) aumentou a expectativa de vida dos portadores do vírus da imunodeficiência humana (HIV) e, como conseqüência, torna-se constante o estudo do processo fisiopatológico da infecção e das estratégias de intervenção que possam melhorar a qualidade de vida destes indivíduos. O treinamento concorrente, definido como a associação dos componentes aeróbios e força na mesma sessão de exercícios pode ser inserido neste contexto. O objetivo deste artigo é revisar os aspectos centrais da infecção pelo HIV e as evidências existentes sobre o treinamento concorrente com séries múltiplas e simples nos parâmetros imunológico, virológico, cardiorrespiratório e neuromuscular de pessoas infectadas pelo HIV. O método utilizado foi uma revisão sistemática, com artigos publicados entre 2000-2007, nas bases de dados scielo e pubmed e também em dissertações e teses da biblioteca digital da educação física, esporte e saúde. As evidências científicas encontradas nos 8 estudos analisados indicam que o treinamento concorrente, tanto com séries múltiplas quanto séries simples, melhora os parâmetros cardiorrespiratório e neuromuscular; no entanto, os resultados dos parâmetros imunológico e virológi-co ainda não estão completamente esclarecidos, principalmente sobre os protocolos com séries simples. Considerando o número restrito de trabalhos apresentados, sugere-se o desenvolvimento de estudos com treinamento concorrente em vários desfechos clínicos para pessoas infectadas pelo HIV.Palavras-chave: HIV, treinamento concorrente, exercício físico. ABSTRACTThe highly active antiretroviral therapy (HAART) increased life expectancy in individuals infected with the human immunodeficiency virus (HIV). Alternative strategies have been used in order to improve their quality of life and minimize the HAART effect; among these we can name physical exercise. Concurrent training, the combination of aerobic and strength training in the same exercise session, is used to improve aerobic and strength capacities with shorter time of training and stands out within the used methods. It is crucial to understand this syndrome's characteristics for the best application of physical exercise in the HIV infected patients. Therefore, the aim of this study is to review the main HIV infection characteristics and the evidence available on concurrent training with single and multiple sets in immunological, virological, cardiorespiratory and neuromuscular parameters in subjects living with HIV/AIDS. A systematic review of papers published from 2000-2007 in the Scielo and Pubmed database, as well as theses and dissertations on Physical Education, Sports and Health fields from the digital library totalizing 8 studies, was performed. Evidence from these 8 investigated studies showed that concurrent training, both with single and multiple sets, improves cardiorespiratory and neuromuscular parameters. However, the results in the immunological and virological parameters are not completely understood, especially on protocols with...

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“…The number of circulating CD4 + T lymphocytes correlates inversely with the level of viral replication, and persistently high plasma viral loads predict a rapid disease onset. 1 In addition to the depletion of CD4 + T cells, CD8 T cells are also prone to be premature, and CD95/Fas-mediated apoptosis [2][3][4] and the expression of CD38 have been found to be a strong predictor of AIDS after both short-and long-term HIV infection. 5 T cell homeostasis is governed by various cytokines, [6][7][8] including interleukin (IL)-15.…”

Section: T He Main Immunological Effect Of Hiv-1 Infection Is the Promentioning

confidence: 99%

Expression of Interleukin-15 and Interleukin-15Rα in Monocytes of HIV Type 1-Infected Patients with Different Courses of Disease Progression

Tarkowski

Ferraris²,

Martone³

et al. 2012

AIDS Research and Human Retroviruses

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Interleukin-15 (IL-15) enhances the effector mechanisms of anti-HIV immune responses and thus is considered a potential adjuvant of HIV-1 vaccine. However, there are a lack of data concerning the relationships between IL-15 expression and regulation in HIV-1-infected patients and the course of disease progression. We found that IL-15, but not IL-15Ra, is expressed at significantly higher levels in the CD14 + monocytes [stimulated or not with interferon (IFN)-c] of long-term nonprogressors (LTNP) than in those of HIV-1 progressors or healthy controls. There was no between-group difference in the amounts of soluble IL-15 released from the cells. We also found that like the healthy controls, the LTNP expressed the IL-15 and IL-15Ra genes in a more coordinated manner than the progressors. Our findings show that there are significant differences in IL-15 expression between patients with different courses of HIV infection, and that the coordinated expression of the IL-15 and IL-15Ra genes is dysregulated in patients with progressive disease. They also provide important information concerning the mechanisms of infection and the potential use of IL-15 as a therapeutic agent.

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Predictors of disease progression in HIV infection: a review

Cited by 250 publications

References 144 publications

High Incidence of Pulmonary Tuberculosis in ART Naive Remunerated Blood Donors with Human Immunodeficiency Virus Type-1 Infection: Possible Role of Iron Overload

High Incidence of Pulmonary Tuberculosis in ART Naive Remunerated Blood Donors with Human Immunodeficiency Virus Type-1 Infection: Possible Role of Iron Overload

HIV/AIDS e Treinamento Concorrente: a Revisão Sistemática

Expression of Interleukin-15 and Interleukin-15Rα in Monocytes of HIV Type 1-Infected Patients with Different Courses of Disease Progression

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