FITC and Ru(phen)3
2+ co-doped silica particles as visualized ratiometric pH indicator

Xu, Jianquan; Sun, Lei; Li, Jun; Liang, Jinglun; Zhang, Huimao; Yang, Wensheng

doi:10.1186/1556-276x-6-561

Cited by 32 publications

(23 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prior to experimental use, the Nano-SiO 2 were dispersed under a sonicator for 5 minutes (Bioruptor ® UCD-200; Diagenode s.a., Liege, Belgium). The red fluorescent-labeled Nano-SiO 2 was prepared and characterized in our previous study 16 and used for the cellular uptake experiment only.…”

Section: Methodsmentioning

confidence: 99%

Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway

Duan

et al. 2014

IJN

149

View full text Add to dashboard Cite

Although nanoparticles have a great potential for biomedical applications, there is still a lack of a correlative safety evaluation on the cardiovascular system. This study is aimed to clarify the biological behavior and influence of silica nanoparticles (Nano-SiO 2 ) on endothelial cell function. The results showed that the Nano-SiO 2 were internalized into endothelial cells in a dose-dependent manner. Monodansylcadaverine staining, autophagic ultrastructural observation, and LC3-I/LC3-II conversion were employed to verify autophagy activation induced by Nano-SiO 2 , and the whole autophagic process was also observed in endothelial cells. In addition, the level of nitric oxide (NO), the activities of NO synthase (NOS) and endothelial (e)NOS were significantly decreased in a dose-dependent way, while the activity of inducible (i)NOS was markedly increased. The expression of C-reactive protein, as well as the production of proinflammatory cytokines (tumor necrosis factor α, interleukin [IL]-1β, and IL-6) were significantly elevated. Moreover, Nano-SiO 2 had an inhibitory effect on the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway. Our findings demonstrated that Nano-SiO 2 could disturb the NO/NOS system, induce inflammatory response, activate autophagy, and eventually lead to endothelial dysfunction via the PI3K/Akt/mTOR pathway. This indicates that exposure to Nano-SiO 2 is a potential risk factor for cardiovascular diseases.

show abstract

Section: Methodsmentioning

confidence: 99%

Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway

Duan

et al. 2014

IJN

149

View full text Add to dashboard Cite

show abstract

“…The particles located in the lysosomes where the pH was measured to be 4.8 and successfully monitored the drug-stimulated increase in pH to 6.8. A pH-sensitive naphthalimide-derivative and a reference rhodamine dye was used in modified Stöber particles for ratiometric detection of pH by Doussineau et al [160]. Xu et al used a combination of a pH-sensitive fluorescein dye and a pH-insensitive ruthenium dye complex for ratiometric detection of pH in a Stöber-based silica nanoparticle matrix with core-shell configuration.…”

Section: Ph Sensingmentioning

confidence: 99%

Micro- and nanostructured sol-gel-based materials for optical chemical sensing (2005–2015)

2016

View full text Add to dashboard Cite

This review (with 172 references) highlights the progress made in the past 10 years in silica sol-gel-based materials for use in optical chemical sensing. Following an introduction, the processes leading to the sol-gel-based and ormosil materials, their printability and methods for characterisation are discussed. Then various classes of optical sensors, with a focus on sensors for pH values, oxygen, carbon dioxide, ammonia (also in dissolved form), and heavy metal ions are described. A further section covers nanoparticle-based optical sensors mainly for use in intracellular sensing of the above species. Recent developments in this area are also emphasised and future trends discussed.

show abstract

“…To reduce Ru(III) to Ru(II), 0.2-0.6 g of hydroxylamine hydrochloride (Reachim, Purum) was added to each solution with a subsequent heating in a water bath at 100 • C for 2 h. After that all solutions were subjected to spectrophotometry analysis. Ruthenium content was determined by the intensity of the absorption band for the complex [Ru(phen) 3 ] 2+ at 449 nm (ε = 1.5 × 10 4 M −1 ·cm −1 ) [110].…”

Section: Analyses and Instrumentationsmentioning

confidence: 99%

Dendrimer-Stabilized Ru Nanoparticles Immobilized in Organo-Silica Materials for Hydrogenation of Phenols

et al. 2017

View full text Add to dashboard Cite

New hybrid catalysts based on Ru nanoparticles, encapsulated into poly(propylene imine dendrimers), immobilized into silica pores, were synthesized and examined for the hydrogenation of alkyl-substituted phenols. The corresponding alkyl-substituted cyclohexanols were presented as the major reaction products, while incomplete hydrogenation products appeared to be minor. A competition between the sterical factors of dendrimer-containing carriers and the electronic factors of substrate substituents influenced the hydrogenation rate of the alkyl-substituted phenols. The carrier structure was found to have a significant influence on both the physical and chemical properties of the catalysts and their hydrogenation activity. The synthesized hybrid catalysts appeared to be stable after recycling and could be re-used several times without significant loss of activity.

show abstract

FITC and Ru(phen)3 2+ co-doped silica particles as visualized ratiometric pH indicator

Cited by 32 publications

References 26 publications

Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway

Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway

Micro- and nanostructured sol-gel-based materials for optical chemical sensing (2005–2015)

Dendrimer-Stabilized Ru Nanoparticles Immobilized in Organo-Silica Materials for Hydrogenation of Phenols

Contact Info

Product

Resources

About