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Cited by 412 publications
(24 citation statements)
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“…The up-regulated mRNAs in ABIN1[D485N] monocytes included that encoding myeloperoxidase (MPO) and, consistent with this finding, the MPO protein was also up-regulated (Figs S7C and D, and S8A). MPO catalyses the formation of hypochlorous acid (Hampton et al, 1998), a potent bactericidal non-radical oxidant. The RNAs encoding the proteinases elastase ( elane ), proteinase 3 ( prtn3 ), cathepsin G ( ctsg ), and cathelicidin ( camp ) were also up-regulated in pMo and iMo from ABIN1[D485N] mice.…”
Section: Resultsmentioning
confidence: 99%
“…The up-regulated mRNAs in ABIN1[D485N] monocytes included that encoding myeloperoxidase (MPO) and, consistent with this finding, the MPO protein was also up-regulated (Figs S7C and D, and S8A). MPO catalyses the formation of hypochlorous acid (Hampton et al, 1998), a potent bactericidal non-radical oxidant. The RNAs encoding the proteinases elastase ( elane ), proteinase 3 ( prtn3 ), cathepsin G ( ctsg ), and cathelicidin ( camp ) were also up-regulated in pMo and iMo from ABIN1[D485N] mice.…”
Section: Resultsmentioning
confidence: 99%
“…Activated neutrophils undergo numerous important changes for the host defense against invading pathogens. The primary responses of neutrophils exposed to bacteria include the production of reactive oxygen species and engulfment of microbes (6). Moreover, recent findings have demonstrated that activated neutrophils also expel nuclear DNA to form web-like structures containing nuclear, cytoplasmatic and granular proteins, which are referred as neutrophil extracellular traps (NETs) (7).…”
Section: Introductionmentioning
confidence: 99%
“…The gluconolactone subsequently becomes siphoned into the pentose phosphate pathway via hydrolysis to form gluconic acid and phosphorylation with ATP to produce 6-phosphogluconate lactone (Dickens and Glock, 1951;Rohatgi et al, 2014). The consequential elevated H 2 O 2 , and its interaction with raised MPO, leads to the activation of various oxidative stress pathways (Hampton et al, 1998;Podrez et al, 2000;Klebanoff, 2005), as depicted in Figure 1, and described above. The two final urinary markers of elevated MPO and of HOCl, via the MPO-H 2 O 2 -Cl 2 system, are predicted to be glutathione sulfonamide and 3-chlorotyrosine (Winterbourn and Kettle, 2000).…”
Section: Proposed Predictive Metabolic Model Of Tbm In the Brain Basementioning
confidence: 97%
“…Borelli et al (1999) proved that purified MPO, in the presence of H 2 O 2 , exerts a consistent killing effect on Mtb, and that the MPO activity is both time and dose dependent; it also requires chloride ions for efficacy. This MPO-H 2 O 2 -Cl 2 system produces hypochlorous acid (HOCl) via activated leukocytes (Klebanoff, 2005), which in turn serves as a strong, non-radical oxidant of a wide range of biological compounds, although it is more selective than hydroxyl radicals (Hampton et al, 1998), with the following characteristics: (1) it has a preferred substrate selectivity toward thiols and thioethers, (2) an ability to convert amines to chloramines, (3) promotes chlorination of phenols and unsaturated bonds, (4) oxidizes iron centers, (5) crosslinks proteins, and (6) is membrane permeable. HOCl has also been characterized as covalently modifying lipids and/or proteins, resulting in local tissue damage and amplification of the inflammatory cascade.…”
Section: Myeloperoxidasementioning
confidence: 99%