Effect of resveratrol and tetracycline on the subacute paraquat toxicity in mice

Abstract

<jats:p> Paraquat (PQ) is a nonselective bipyridyl herbicide widely used in agriculture to control weeds, but its accidental, occupational, or intentional exposure in humans is known to cause pneumo- and neurotoxicity which may proves fatal. Oxidative stress is reported as an underlined mechanism of PQ-induced toxicity in alveolar cells, neurons, and astroglia. PQ generates superoxides both through electron transport reaction (ETC) with nicotinamide adenine dinucleotide–dependent oxidoreductase and by the redox cycling via reaction with molecular oxygen. In lungs, it causes edema and inflammation resulting in neutrophils infiltration and subsequent activation of pro-inflammatory cytokines. In the present study, toxicity of subacute oral PQ exposure and effect of resveratrol (Res) and/or tetracycline (TC) on oxidative stress and inflammatory markers in lungs, brain, and liver was studied. Levels of glutathione and malondialdehyde and activities of myeloperoxidase, glutathione peroxidase, and catalase were measured in lungs, brain, and liver. PQ interferes in the function of mitochondrial ETC complexes causing decreased adenosine triphosphate levels, and hence the activities of complexes I and IV were studied in brain tissues. Res, a natural antioxidant, and TC, an antibiotic with its antimicrobial and anti-inflammatory properties, offered significant protection from severe oxidative stress and inflammation and ameliorated the general well-being of mice against the toxic outcome of PQ. </jats:p>

Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis

“…On the other hand, MDA is one of the most commonly used indicators of lipid peroxidation: the process that has been implicated in several deleterious effects such as increased membrane rigidity, osmotic fragility, and reduced mitochondrial survival [ 39 ]. We and others demonstrated lipid peroxidation as a biomarker of PQ hepatic toxicity [ 37 , 40 , 41 ]. It was demonstrated that Res can modulate cellular redox in several models of liver injury [ 11 – 13 ] and in subacute PQ toxicity in mice [ 41 ].…”

“…We and others demonstrated lipid peroxidation as a biomarker of PQ hepatic toxicity [ 37 , 40 , 41 ]. It was demonstrated that Res can modulate cellular redox in several models of liver injury [ 11 – 13 ] and in subacute PQ toxicity in mice [ 41 ]. Similarly, MK has been shown to diminish oxidative stress markers and enhance antioxidants in rat liver [ 16 , 17 , 42 ].…”

Interactions between oxidative stress and attractiveness to mates and individual mate choice in the beetle Tenebrio molitor

“…Animals treated with PQ tend to succumb (Bonilla et al., 2006; Martínez‐Lendech et al., 2018; Sittipunt, 2005). Antioxidants protect against PQ‐induced oxidative toxicity (Bonilla et al., 2006; Satpute et al., 2017; Thiruchelvam et al., 2005), while PQ affords protection in individuals infected with pathogens that produce antioxidants to avoid the host pro‐oxidant defenses (Medina‐Gómez et al., 2018). Based on the aforementioned evidence, PQ appears to cause oxidative stress in T. molitor .…”

Phytochemical Screening of Cinnamon Cassia and Its Protective Effects Against Hepatotoxicity Induced By Difenoconazole in Male Albino Rats.

“…In the current ,an increase signi cantly in the activities of serum ALT and AST was observed following treatment with difenoconazole, which have been attributed to leakage of cellular enzymes in circulation as a result of loss function integrity of cell membrane of hypatocytes [ Navaro et al .,1993 andOzer et al .,2008] A number of chemical including agro-pesticides and various environmental pollutanta can severe cellular damage in different organs in the body .This occurred through metabolic activation to highly reactive substances such as free radicals (Satpute et al, 2017).…”