Curcumin Inhibits UV Radiation–Induced Skin Cancer in SKH‐1 Mice

Phillips, Jeffrey; Moore-Medlin, Tara; Sonavane, Kunal; Ekshyyan, Oleksandr; McLarty, Jerry; Nathan, Cherie‐Ann O.

doi:10.1177/0194599813476845

Cited by 35 publications

(25 citation statements)

References 24 publications

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“…The major agent causing skin cancer is UV radiation from sunlight (Sarasin 1999); chronic exposure to UV radiation leads to skin cancer (Koh 1995). Given the increasing morbidity, incidence, and cost of this disease, research has focused on seeking novel chemopreventive agents that will inhibit non-melanoma skin cancer formation and progression (Phillips et al 2013). Investigations using animal models and epidemiological studies indicate that dietary consumption of phytochemicals might reduce the incidence of cancers and other chronic diseases (Feng et al 2004; Pratheeshkumar et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Blackberry extract inhibits UVB-induced oxidative damage and inflammation through MAP kinases and NF-κB signaling pathways in SKH-1 mice skin

Divya

Wang

Pratheeshkumar

et al. 2015

Toxicology and Applied Pharmacology

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Extensive exposure of solar ultraviolet-B (UVB) radiation to skin induces oxidative stress and inflammation that play a crucial role in the induction of skin cancer. Photochemoprevention with natural products represents a simple but very effective strategy for the management of cutaneous neoplasia. In this study, we investigated whether blackberry extract (BBE) reduces chronic inflammatory responses induced by UVB irradiation in SKH-1 hairless mice skin. Mice were exposed to UVB radiation (100 mJ/cm2) on alternate days for 10 weeks, and BBE (10% and 20%) was applied topically a day before UVB exposure. Our results show that BBE suppressed UVB-induced hyperplasia and reduced infiltration of inflammatory cells in the SKH-1 hairless mice skin. BBE treatment reduced glutathione (GSH) depletion, lipid peroxidation (LPO), and myeloperoxidase (MPO) in mouse skin by chronic UVB exposure. BBE significantly decreased the level of pro-inflammatory cytokines IL-6 and TNF-α in UVB-exposed skin. Likewise, UVB-induced inflammatory responses were diminished by BBE as observed by a remarkable reduction in the levels of phosphorylated MAP Kinases, Erk1/2, p38, JNK1/2 and MKK4. Furthermore, BBE also reduced inflammatory mediators such as cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), and inducible nitric oxide synthase (iNOS) levels in UVB-exposed skin. Treatment with BBE inhibited UVB-induced nuclear translocation of NF-κB and degradation of IκBα in mouse skin. Immunohistochemistry analysis revealed that topical application of BBE inhibited the expression of 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodG), cyclobutane pyrimidine dimers (CPD), proliferating cell nuclear antigen (PCNA), and cyclin D1 in UVB-exposed skin. Collectively, these data indicates that BBE protects from UVB-induced oxidative damage and inflammation by modulating MAP kinase and NF-κB signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Blackberry extract inhibits UVB-induced oxidative damage and inflammation through MAP kinases and NF-κB signaling pathways in SKH-1 mice skin

Divya

Wang

Pratheeshkumar

et al. 2015

Toxicology and Applied Pharmacology

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“…Recently it has been reported that oral curcumin, 6.0 g daily during radiotherapy, reduced the severity of radiation dermatitis in breast cancer patients [19]. In animal model oral administration of curcumin inhibited cancer of lung [20], skin [21], head and neck [22], oral [23], hepatocellular carcinoma [24], mammary tumors, lymphomas, leukemias [25], and familial adenomatous polyposis [26]. Oral treatment of curcumin found to effective in diabetic condtion.…”

Section: Delivery Of Curcuminmentioning

confidence: 99%

“…Average number of tumors formed per mouse was lesser in curcumin and UVB treated mice compared to UVB exposed animals and it also delayed the onset of tumorigenesis [21]. Beside these when curcumin applied as a noninvasive topical paste to the head and neck squamous cell carcinoma (HNSCC) xenografts tumors in mice, resulted in inhibition of its growth.…”

Section: Intravenous Deliverymentioning

confidence: 99%

Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice

2014

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Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6,000 citations. In addition, over one hundred clinical studies have been carried out with curcumin. One of the major problems with curcumin is perceived to be the bioavailability. How curcumin should be delivered in vivo, how bioavailable is it, how well curcumin is absorbed and how it is metabolized, is the focus of this review. Various formulations of curcumin that are currently available are also discussed.

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“…Chronic exposure to UV radiations leads to skin cancer (Koh, 1995). Given the increasing morbidity, incidence, and cost, research has been focused on exploring novel chemopreventive agents that inhibit nonmelanoma skin cancer formation and progression (Phillips et al , 2013). Natural products have been used for the treatment of various diseases and are becoming an important research area for drug discovery (Pratheeshkumar et al , 2012).…”

Section: Discussionmentioning

confidence: 99%

Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-κB signaling pathways in SKH-1 hairless mice skin

Pratheeshkumar¹,

Son²,

Wang³

et al. 2014

Toxicology and Applied Pharmacology

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Skin cancer is one of the most commonly diagnosed cancers in the United States. Exposure to ultraviolet-B (UVB) radiation induces inflammation and photocarcinogenesis in mammalian skin. Cyanidin-3-Glucoside (C3G), a member of the anthocyanin family, is present in various vegetables and fruits especially in edible berries, and displays potent antioxidant and anticarcinogenic properties. In this study, we have assessed the in vivo effects of C3G on UVB irradiation induced chronic inflammatory responses in SKH-1 hairless mice, a well-established model for UVB-induced skin carcinogenesis. Here, we show that C3G inhibited UVB-induced skin damage and inflammation in SKH-1 hairless mice. Our results indicate that C3G inhibited glutathione depletion, lipid peroxidation and myeloperoxidation in mouse skin by chronic UVB exposure. C3G significantly decreased the production of UVB-induced pro-inflammatory cytokines, such as IL-6 and TNF-α, associated with cutaneous inflammation. Likewise, UVB-induced inflammatory responses were diminished by C3G as observed by a remarkable reduction in the levels of phosphorylated MAP Kinases, Erk1/2, p38, JNK1/2 and MKK4. Furthermore, C3G also decreased UVB-induced cyclooxygenase-2 (COX-2), PGE2 and iNOS levels, which are well-known key mediators of inflammation and cancer. Treatment with C3G inhibited UVB-induced nuclear translocation of NF-κB and degradation of IκBα in mice skin. Immunofluorescence assay revealed that topical application of C3G inhibited the expression of 8-hydroxy-2′-deoxyguanosine, proliferating cell nuclear antigen, and cyclin D1 in chronic UVB exposed mouse skin. Collectively, these data indicates that C3G can provide substantial protection against the adverse effects of UVB radiation by modulating UVB-induced MAP kinase and NF-κB signaling pathways.

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Curcumin Inhibits UV Radiation–Induced Skin Cancer in SKH‐1 Mice

Abstract: Curcumin appears to inhibit skin cancer formation and prolong time to tumor onset when administered by either an oral or topical route. These data suggest that curcumin may have chemopreventive potential against skin cancer, necessitating future experimentation with human subjects.

Cited by 35 publications

References 24 publications

Blackberry extract inhibits UVB-induced oxidative damage and inflammation through MAP kinases and NF-κB signaling pathways in SKH-1 mice skin

Blackberry extract inhibits UVB-induced oxidative damage and inflammation through MAP kinases and NF-κB signaling pathways in SKH-1 mice skin

Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice

Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-κB signaling pathways in SKH-1 hairless mice skin

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