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Cited by 37 publications
(34 citation statements)
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“…(36) The most widely studied environmental factor is slow virus infection, and over the years, measles, (36) respiratory syncytial virus, (37) and canine distemper (38) have all been implicated and overexpression of measles virus nucleocapsids protein in experimental models has been shown to increase bone remodeling. (39) Attempts to detect evidence of paramyxovirus nucleic acids and proteins in patient material have yielded conflicting results, however, (40)(41)(42)(43)(44)(45)(46)(47) and serological studies have found no evidence of an enhanced immune response to paramyxoviruses in PDB. (48) It has been reported that the nuclear inclusion bodies that were identified in PDB many decades ago and thought to be measles virus nucleocapsids (36) are morphologically distinct from measles on ultrastructural analysis.…”
Section: Introductionmentioning
confidence: 99%
“…(36) The most widely studied environmental factor is slow virus infection, and over the years, measles, (36) respiratory syncytial virus, (37) and canine distemper (38) have all been implicated and overexpression of measles virus nucleocapsids protein in experimental models has been shown to increase bone remodeling. (39) Attempts to detect evidence of paramyxovirus nucleic acids and proteins in patient material have yielded conflicting results, however, (40)(41)(42)(43)(44)(45)(46)(47) and serological studies have found no evidence of an enhanced immune response to paramyxoviruses in PDB. (48) It has been reported that the nuclear inclusion bodies that were identified in PDB many decades ago and thought to be measles virus nucleocapsids (36) are morphologically distinct from measles on ultrastructural analysis.…”
Section: Introductionmentioning
confidence: 99%
“…The high levels of OCL-derived IL-6 induced IGF1 and EphB2 in OCLs, and EphB4 on OBs, to increase OB differentiation in vitro (13). Furthermore, we previously reported that EphB4-Fc treatment of OCL precursors from WT and MVNP mice inhibited OCL formation, decreased bone resorption, and abrogated the effects of MVNP on the expression of a pagetic phenotype by the OCLs that formed.…”
Section: Introductionmentioning
confidence: 78%
“…Several studies implicated expression of Eph receptors on OBs and ephrins on OCLs and OBs as major regulators of coupling (11,12). We recently reported that MVNP-expressing OCLs from patients with PD and MVNP mice express high levels of IL-6, IGF1, and EphB2 (13).…”
Section: Introductionmentioning
confidence: 95%
“…MVNP has been implicated in the pathogenesis of PDB [28]. Earlier, we showed that patients with PDB contain elevated levels of FGF-2 and chemokine CXCL5, which modulate osteoclastogenesis through induction of RANKL expression in osteoblast cells [19,29].…”
Section: Discussionmentioning
confidence: 99%