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Cited by 1,471 publications
(1,124 citation statements)
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References 49 publications
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“…A number of other reports using a variety of chemotherapies and a variety of approaches to blocking NF-kB support this model (Baldwin, 2001;Yamamoto and Gaynor, 2001;Karin et al, 2002;Nakanishi and Toi, 2005). The recent review by Nakanishi and Toi (2005) provides a thorough outline of different chemotherapies that activate NF-kB and of compounds that can be used to block NF-kB activation to promote cancer therapy efficacy.…”
Section: Nf-jb Activation and Cancer Therapymentioning
confidence: 90%
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“…A number of other reports using a variety of chemotherapies and a variety of approaches to blocking NF-kB support this model (Baldwin, 2001;Yamamoto and Gaynor, 2001;Karin et al, 2002;Nakanishi and Toi, 2005). The recent review by Nakanishi and Toi (2005) provides a thorough outline of different chemotherapies that activate NF-kB and of compounds that can be used to block NF-kB activation to promote cancer therapy efficacy.…”
Section: Nf-jb Activation and Cancer Therapymentioning
confidence: 90%
“…These include compounds that have already been approved for use in therapy, compounds that are undergoing clinical trials and compounds that show therapeutic promise in preliminary studies (see below). In summary, extensive evidence demonstrates that compounds which block NF-kB activation can serve to block cancer cell growth (Baldwin, 2001;Yamamoto and Gaynor, 2001;Karin et al, 2002;Gilmore and Herscovitch, 2006).…”
Section: Approaches To Blocking Nf-jb For Cancer Therapymentioning
confidence: 99%
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“…Correlation analysis indicated that the mRNA levels of pro-inflammatory cytokines TNF-a, IL-1b, IL-8, IFN-g2 and IL-12p40 were positively correlated with the mRNA levels of NF-kB P65 and NF-kB P52 in the gills of grass carp ( Table 5). The nuclear translocation of NF-kB may be inhibited by IkBa in humans [69], and Heissmeyer et al [70] reported that the IKK complex (including IKKa, IKKb and IKKg) catalyses IkBa degradation in 293 cells. In the present study, compared with low or high levels of protein, we found that the optimal levels of dietary protein led to the down-regulation of IKKa, IKKb and IKKg mRNA levels and the up-regulation of IkBa mRNA level in the gills of grass carp.…”
Section: Optimal Level Of Dietary Protein Attenuated Inflammatory Resmentioning
confidence: 99%