Fatores de risco associados a náuseas e vômitos induzidos por quimioterapia antineoplásica

Simino, Giovana Paula Rezende; Reis, Ilka Afonso; Acúrcio, Francisco de Assis; Andrade, Eli Iôla Gurgel; Brazil, Natalia Maria Linhares; Cherchiglia, Mariângela Leal

doi:10.11606/s1518-8787.2020054002178

Cited by 7 publications

(10 citation statements)

References 26 publications

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“…Chemotherapy plays an important role in the treatment of malignant tumors, and CINV is one of the common adverse reactions of chemotherapy. Chemotherapeutic drugs can act directly on the intestinal mucosa through the intestinal lumen, or activate the chemoreceptor trigger zone through the blood circulation, which promotes the release of a variety of neurotransmitters and acts on the vomiting center, resulting in nausea and vomiting [ 24 , 25 ]. The National Comprehensive Cancer Network classifies emetogenic antineoplastic agents into four levels [ 26 ], and different antineoplastic agents, have different emetogenic risks.…”

Section: Discussionmentioning

confidence: 99%

Mechanism and risk factors of nausea and vomiting after TACE: a retrospective analysis

Zheng

Liang

et al. 2021

BMC Cancer

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Purpose The mechanism of postoperative nausea and vomiting after TACE is not clear. This study retrospectively analyzed the patient data to explore the mechanism and risk factors of postoperative nausea and vomiting after TACE. Materials and methods The data of 221 patients who underwent TACE in the interventional department from January 2019 to December 2020 were collected. Including: gender, age, liver function before TACE, etiology of liver cirrhosis, BCLC stage of hepatocellular carcinoma, preoperative use of analgesic drugs, preoperative limosis, previous history of vomiting, history of kinetosis, smoking history, history of drinking, chemotherapeutic drugs used during TACE, Dosage of lipiodol, and occurrence of postoperative nausea and vomiting. Results There were 116 cases of nausea after TACE, using binary logistic regression analysis, Sig: ALT0.003; ALP0.000; history of vomiting 0.043; kinetosis 0.006; history of alcohol consumption 0.011; preoperative limosis 0.006; dosage of lipiodol (5–10 mL) 0.029, dosage of lipiodol (> 10 mL) 0.001.There were 89 cases of vomiting after TACE, all accompanied by nausea, Sig: ALP0.000; BCLC stage (B) 0.007; kinetosis 0.034; chemotherapeutic drugs 0.015; dosage of lipiodol (5–10 ml) 0.015, dosage of lipiodol (> 10 ml) 0.000; patients used analgesics before TACE 0.034. Conclusions Causes of post-TACE nausea and vomiting included operative trauma, aseptic inflammation caused by ischemia and hypoxia, chemotherapeutic drugs, ischemia of liver and bile duct, stress and pain during TACE, and patient factors. ALP, BCLC stage, kinetosis, chemotherapeutic drugs, dosage of lipiodol, and preoperative usage of analgesics were risk factors affecting nausea and vomiting after TACE.

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Section: Discussionmentioning

confidence: 99%

Mechanism and risk factors of nausea and vomiting after TACE: a retrospective analysis

Zheng

Liang

et al. 2021

BMC Cancer

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“…A longitudinal, prospective, descriptive study with a quantitative approach. The study is part of a cohort 14 observing the incidence of nausea and vomiting in chemotherapy-naive patients, as well as the quality of life using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30). The original study enrolled patients aged 18 or older, who were initiating outpatient chemotherapy treatment for the first time.…”

Section: Study Population and Designmentioning

confidence: 99%

Quality of life of patients with cancer undergoing chemotherapy in hospitals in Belo Horizonte, Minas Gerais State, Brazil: does individual characteristics matter?

et al. 2021

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This study aims to evaluate changes in quality of life of cancer patients at the beginning of the first and the second cycle of chemotherapy (CT) in hospitals in Belo Horizonte, Minas Gerais State, Brazil. Longitudinal, prospective, descriptive study with a quantitative approach. We enrolled 230 patients, from a broader cohort, diagnosed with the five most frequent types of cancer (breast, colorectal, cervical, lung, and head and neck), aged 18 years or older, who were initiating CT for the first time. quality of life was assessed with the EORTC QLQ-C30 version 3, applied at the beginning of the first and second chemotherapy cycle. The paired Wilcoxon test was used to identify differences in quality of life between the two time points. A multivariate linear regression analysis was performed using the bootstrap method to investigate potential predictors of global health Status/quality of life. There was a significant increase in patients’ emotional function scores (p < 0.001) as well as symptom scores for pain (p = 0.026), diarrhea (p = 0.018), and nausea/vomiting (p < 0.001) after initiation of CT. Widowhood was associated with improvements in the global health Status/quality of life (p = 0.028), whereas the presence of cervical cancer (p = 0.034) and being underweight (p = 0.033) were related to poorer global health status/quality of life scores. CT has detrimental effects on patients’ physical health but, on the other hand, it leads to improvements in the emotional domain. Patients’ individual characteristics at the beginning of CT are associated with changes in their quality of life. Our study could help identify these characteristics.

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“…A utilização do protocolo quimioterápico pode ocasionar efeitos adversos que afetam a qualidade de vida, aumentam custos e favorecem à interrupção do tratamento. Dentre os efeitos adversos gastrointestinais mais frequentes induzidos pela quimioterapia antineoplásica, têm-se as náuseas e vômitos, que favorecem a ocorrência de inapetência, perda de peso, diminuição do convívio social e até consequências clínicas mais graves, como desidratação e caquexia (Simino et al, 2020).…”

Section: Introductionunclassified

A presença de sintomas gastrointestinais e perda de peso como fatores de risco para desnutrição em pacientes com câncer gástrico em tratamento quimioterápico

Tavares

Queiroz²,

Silva³

et al. 2023

RSD

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Introdução: O Câncer Gástrico (CG) é o quinto câncer mais comum no mundo e a terceira causa mais comum de câncer relacionado a morte. O tratamento é multimodal, e dentre as terapêuticas utilizadas têm-se a quimioterapia, que pode gerar sintomas como náuseas e vômitos, interferindo no estado nutricional do paciente. Objetivo: Avaliar se a presença de sintomas gastrointestinais e perda de peso representam fatores de risco para desnutrição em pacientes com câncer gástrico em tratamento quimioterápico. Metodologia: Estudo transversal de cunho descritivo e analítico, com amostragem não probabilística por conveniência. Realizado com pacientes diagnosticados com câncer gástrico, adultos e idosos de ambos os sexos, no período de maio de 2021 a agosto de 2022. Para análise estatística foi utilizado testes de correlação, associação e regressão, sendo adotado 5% de significância. Resultados: Foram avaliados 30 pacientes, 40,0% apresentaram desnutrição segundo IMC, 53,3% apresentaram perda de peso e 46,6% apresentaram sintomas gastrointestinais, sendo mais prevalente as náuseas e a inapetência. Conclusão: Embora a presença de sintomas gastrointestinais e ocorrência de perda de peso não tenha sido considerada fator de risco de acordo com o teste regressão, a atenção e manejo adequado da equipe multidisciplinar é crucial para evitar a ocorrência destes agravantes e intervir de forma assertiva para promover melhora do estado nutricional, capacidade funcional e qualidade de vida desses pacientes.

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Fatores de risco associados a náuseas e vômitos induzidos por quimioterapia antineoplásica

Cited by 7 publications

References 26 publications

Mechanism and risk factors of nausea and vomiting after TACE: a retrospective analysis

Mechanism and risk factors of nausea and vomiting after TACE: a retrospective analysis

Quality of life of patients with cancer undergoing chemotherapy in hospitals in Belo Horizonte, Minas Gerais State, Brazil: does individual characteristics matter?

A presença de sintomas gastrointestinais e perda de peso como fatores de risco para desnutrição em pacientes com câncer gástrico em tratamento quimioterápico

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