Characterization of women with cervical cancer assisted at Inca by histological type

Rozario, Suelem do; Silva, Iléia Ferreira da; Koifman, Rosalina Jorge; Silva, Ilce Ferreira da

doi:10.11606/s1518-8787.2019053001218

Cited by 15 publications

(17 citation statements)

References 27 publications

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“…The results show a higher prevalence for the age group from 65 to 70 years (30.2%). Age was not associated with late staging, although the literature indicates that in developed countries, older women are diagnosed more frequently in advanced stages than younger women, where each additional year in age the chance of having the diagnosis in the late stage increases by 3 % (7) .…”

Section: Discussionmentioning

confidence: 83%

Associação entre variáveis demográficas e estadiamento de câncer cervical em idosas: estudo retrospectivo

et al. 2021

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Objetivo: Associar as variáveis sociodemográficas de idosas com câncer cervical e estadiamento de um hospital de referência oncológica. Método: Estudo observacional, retrospectivo e analítico de 559 idosas. Resultados: As variáveis que apresentaram correlação estatística significativa com o estadiamento do câncer do colo do útero foram: idosas casadas, o tipo histopatológico carcinoma de células escamosas, radioterapia + quimioterapia como primeiro tratamento recebido no hospital, remissão completa da doença ao final do primeiro tratamento, sem óbitos por câncer e nunca haver fumado. Discussão: Embora algumas características estarem relacionadas a maior prevalência elas não estavam associadas ao estadiamento. Conclusão: Os dados do estudo reafirmam a necessidade de prevenção e busca ativa dos casos. Conhecer as características epidemiológicas dessas idosas, torna-se significativo, pois fornece subsidio para o planejamento avaliação de programas efetivos no controle do câncer do colo do útero.

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Section: Discussionmentioning

confidence: 83%

Associação entre variáveis demográficas e estadiamento de câncer cervical em idosas: estudo retrospectivo

et al. 2021

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“…Karakteristik onkogenik HPV berasal dari onkoprotein E6 dan E7 yang bertindak menghambat p53 dan penekan tumor pRB. Sekitar 5% dari semua kanker secara global disebabkan terutama oleh HPV yang dikenal sebagai HPV risiko tinggi, termasuk HPV tipe 16,18,31,33,35,39, 45, 51, 52, 56, 58, dan 59. 5,6 Infeksi HPV sering terjadi setelah memulai aktifitas seksual terutama bagi seseorang yang memiliki banyak pasangan dalam beraktifitas seksual.…”

Section: Pendahuluanunclassified

Onkogenesis, Morfologi, dan Modalitas Deteksi Dini Karsinoma Serviks

Rapar

Sambuaga

Durry

2021

MSJ

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The incidence and mortality rates of cervical cancer in developing countries are relatively high compared to developed countries. The main risk factor for cervical cancer is high risk human papilloma virus (HPV) infection, such as types 16 and 18. Types of high-risk HPV expresses oncoproteins E6 and E7 which play an essential role in the pathogenesis of cervical carcinoma through inhibition of the activity of gene group expression products that play a role in suppressing tumor growth, such as p53 and pRB. This process will cause morphological changes in the squamous epithelium from precancerous lesions to cancer. The development of squamous epithelial cell cancer can be prevented through screening tests in order to detect cervical cancer early. This study was aimed to obtain the oncogenesis, morphology, and early detection modality of cervical carcinoma. This was a literature review study using three databases, as follows: ClinicalKey, PubMed, and Google Scholar. The results explained that p53 and pRB suppression by high-risk HPV oncoproteins E6 and E7 played an important role in the pathogenesis of cervical carcinoma. The most common histological type is squamous cell carcinoma. Screening tests such as visual inspection with acetic acid (VIA), Pap smears and HPV DNA have an important role as modalities for early detection of malignancy. More specifically VIA and Pap smears are suitable for Indonesia which is a developing country, especially when implemented in peripheral areas.Keywords: oncogenesis; morphological changes; early detection; cervical carcinoma Abstrak: Insidens dan mortalitas kanker serviks di negara berkembang relatif tinggi dibandingkan negara maju. Faktor risiko utama dari kanker serviks adalah infeksi human papilloma virus (HPV) risiko tinggi yaitu tipe 16 dan 18. HPV tipe risiko tinggi mengekspresikan onkoprotein E6 dan E7, yang berperan penting dalam patogenesis karsinoma serviks melalui inhibisi terhadap aktivitas produk-produk ekspresi kelompok gen yang berperan dalam menekan pertumbuhan tumor, seperti p53 dan pRB. Proses ini akan menyebabkan perubahan morfologik pada epitel skuamosa mulai dari lesi prakanker sampai kanker. Perkembangan kanker sel epitel skuamosa dapat dicegah melalui pemeriksaan skrining guna mendeteksi dini kanker serviks. Penelitian ini bertujuan untuk mengetahui onkogenesis, morfologi, dan modalitas deteksi dini karsinoma serviks. Jenis penelitian ialah literature review menggunakan tiga basis data yaitu ClinicalKey, PubMed, dan Google Scholar. Hasil penelitian mendapatkan bahwa penekanan p53 dan pRB oleh onkoprotein HPV risiko tinggi E6 dan E7 sangat berperan penting dalam patogenesis karsinoma serviks. Tipe histologik tersering ialah tipe karsinoma sel skuamosa. Pemeriksaan skrining seperti pemeriksaan inspeksi visual dengan asam asetat (IVA), Pap smear dan HPV DNA memiliki peran penting sebagai modalitas deteksi dini keganasan. Lebih khusus IVA dan Pap smear cocok untuk negara Indonesia yang merupakan negara berkembang, terutama bila diimplementasikan di daerah perifer.Kata kunci: onkogenesis; perubahan morfologik; deteksi dini; karsinoma serviks

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“…Up to 80% of the patients present the histological subtype of squamous cell carcinoma and the rest of the cases correspond mainly to adenosquamous carcinoma 260 . Cervical intraepithelial neoplasia is considered the precursor to cervical cancer 261 . It is estimated that its malignant transformation process takes 20 years, but when intraepithelial neoplasia is associated with HPV-16 infection, progression takes only 10 years 262 .…”

Section: Cervical Cancermentioning

confidence: 99%

From Molecular Biology to Epithelial Carcinogenesis

Méndez¹

2021

Preprint

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The theory of the origin of carcinomas suggests that neoplasias from epithelial tissues are the consequence of the reactivation of developmental programs. It proposes a model in which the epithelial cells undergo cellular transitions due to replicative senescence and inflammation towards a mesenchymal-undifferentiated phenotype with cancerous behavior. The conserved pattern of histological progression and the molecular biology of carcinomas is congruent with the view of cancer as a developmental disease. In support of the theory, the experimental literature regarding the molecular, cellular, and histopathological mechanisms associated with epithelial carcinogenesis were aligned according to the premises of the hypothesis. Thereby identified a generic process in the carcinogenesis of the breast, endometrium, prostate, colon, lung, pancreas, bladder, liver, and cervix. Then, is provided a methodology overview of modeling in systems biology derived from previous research testing the hypothesis. The results illustrate the value of the complex systems approach to recover behavior that cannot be inferred only by traditional methods. Specifically, the model suggests that the consistency in the cell types and the directionality of the observed cellular transitions during epithelial carcinogenesis arise from structural constraints in the molecular networks associated with the carcinomas. Overall, the results of the dynamical analysis agree with the premises of the hypothesis and provide an insightful perspective of the potential mechanisms underlying the cellular plasticity displayed during epithelial carcinogenesis. In an era of big data and yet few advances in the underlying causes of chronic diseases, the manuscript also aims to inspire molecular biologists to integrate existing empirical evidence with systems biology modeling in the pursuit of understanding.

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Characterization of women with cervical cancer assisted at Inca by histological type

Cited by 15 publications

References 27 publications

Associação entre variáveis demográficas e estadiamento de câncer cervical em idosas: estudo retrospectivo

Associação entre variáveis demográficas e estadiamento de câncer cervical em idosas: estudo retrospectivo

Onkogenesis, Morfologi, dan Modalitas Deteksi Dini Karsinoma Serviks

From Molecular Biology to Epithelial Carcinogenesis

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