Factors associated with frailty in older adults

Fhon, Jack Roberto Silva; Rodrigues, Rosalina Aparecida Partezani; Santos, Jair Lício Ferreira; Diniz, Marina Aleixo; Santos, Emanuella Barros dos; Almeida, Vanessa Costa; Giacomini, Suelen Borelli Lima

doi:10.11606/s1518-8787.2018052000497

Cited by 67 publications

(93 citation statements)

References 31 publications

(35 reference statements)

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“…2 Its association with poor outcomes has been demonstrated in multiple settings, from the community dwelling population to the surgical population. [3][4][5][6][7][8][9][10] This relationship appears particularly relevant in patients requiring emergent procedures. 11,12 In a recent systematic review of the spine surgery literature, frailty has been demonstrated to affect post-operative outcomes such as adverse events (AEs), mortality, and length of stay (LOS).…”

Section: Introductionmentioning

confidence: 99%

Effect of Frailty on Outcome after Traumatic Spinal Cord Injury

Banaszek

Inglis

Marion

et al. 2020

Journal of Neurotrauma

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Frailty negatively affects outcome in elective spine surgery populations. This study sought to determine the effect of frailty on patient outcome after traumatic spinal cord injury (tSCI). Patients with tSCI were identified from our prospectively collected database from 2004 to 2016. We examined effect of patient age, admission Total Motor Score (TMS), and Modified Frailty Index (mFI) on adverse events (AEs), acute length of stay (LOS), in-hospital mortality, and discharge destination (home vs. other). Subgroup analysis (for three age groups: <60, 61-75, and 76+ years), and multi-variable analysis was performed to investigate the impact of age, TMS, and mFI on outcome. For the 634 patients, the mean age was 50.3 years, 77% were male, and falls were the main cause of injury (46.5%). On bivariate analysis, mFI, age at injury, and TMS were predictors of AEs, acute LOS, and in-hospital mortality. After statistical adjustment, mFI was a predictor of LOS ( p = 0.0375), but not of AEs ( p = 0.1428) or in-hospital mortality ( p = 0.1245). In patients <60 years of age, mFI predicted number of AEs, acute LOS, and in-hospital mortality. In those aged 61-75, TMS predicted AEs, LOS, and mortality. In those 76+ years of age, mFI no longer predicted outcome. Age, mFI, and TMS on admission are important determinants of outcome in patients with tSCI. mFI predicts outcomes in those <75 years of age only. The inter-relationship of advanced age and decreased physiological reserve is complex in acute tSCI, warranting further study. Identifying frailty in younger patients with tSCI may be useful for peri-operative optimization, risk stratification, and patient counseling.

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Section: Introductionmentioning

confidence: 99%

Effect of Frailty on Outcome after Traumatic Spinal Cord Injury

Banaszek

Inglis

Marion

et al. 2020

Journal of Neurotrauma

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“…This was expected as the FP is a syndrome related to the aging process 4 . Thus, the older the volunteer, the greater their likelihood of being frail 36 . On the other hand, the occlusal status, early tooth loss, presence of local and systemic pathologies or even the reduction of salivary flow rate, which are considered to play a major role in MP and MBF 21 , did not differ between groups.…”

Section: Discussionmentioning

confidence: 99%

Mastication and oral sensory function in frail edentulous elderly: a case–control study

Figueredo

Câmara-Souza

Carletti

et al. 2020

International Dental Journal

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Objective: To evaluate the maximum bite force (MBF), masticatory performance and oral sensory function (OSF) of frail edentulous elderly. The correlation of MBF with maximum grip strength (MGS) was also assessed. Methods: Twenty edentulous elderly [10 with and 10 without the frailty phenotype (FP)] were selected to participate in this case–control study. The FP was diagnosed using the criteria of Fried et al., which consider weight loss, exhaustion, physical activity level, weakness and slowness to the evaluation. All volunteers received new complete dentures (CDs) to standardise the occlusal status, and after 2 months of use with no complaint, all variables were assessed. MBF was measured by pressure sensors positioned bilaterally on the first artificial molars. Masticatory performance was assessed using the sieving method and was expressed as the median particle size (X50) of Optocal after 40 masticatory cycles. OSF was evaluated using the oral stereognosis test, and MGS was measured using a dynamometer. Groups were compared using one‐way analysis of variance. The Pearson coefficient of correlation between MBF and MGS was calculated. Results: Frail elderly people showed reduced MBF (P = 0.0431) and larger X50 values (P = 0.0053) than did non‐frail elders, while OSF did not differ between the groups. MBF had a moderate positive correlation with MGS (r = 0.690, P = 0.003). Conclusions: Frail elderly had reduced MBF and impaired mastication. On the other hand, OSF does not seem to be affected by frailty. MBF was moderately correlated with MGS.

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“…It is highly prevalent and needs to be better evaluated through studies with high levels of scientific evidence 1 . It should be considered that elderly patients usually suffer reduced functional capacity [30][31][32][33] , which, added to the fatigue caused by the disease 34 , may result in greater impairment of activities of daily living and interference in QoL [35][36][37] .…”

Section: Discussionmentioning

confidence: 99%

Quality of life of patients with lung cancer: A scoping review

Mota

Júnior

Pereira

et al. 2019

Rev. bras. geriatr. gerontol.

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Objective: To characterize scientific publications on the quality of life of people with lung cancer in order to explore current knowledge of the subject, with emphasis on assessment instruments and methodological aspects. Method: A scoping type literature review was performed. Articles were sought in the databases of the Virtual Health Library, in an integrative manner, with the descriptors: Quality of life and Lung Neoplasms, with no date of publication or language restrictions (n=138). The selection of articles was based on inclusion and exclusion criteria defined in the study proposal. Results: We included 18 publications published between 2006 and 2017, the majority (n = 10) of which had a cross-sectional design. Eight different instruments were used to evaluate the quality of life of patients with lung cancer, four of which were specific for people with cancer. There was a prevalence of the use of the European Organization for Research and Treatment of Cancer Care Quality of Life Questionnaire - EORTC QLQ-C30 (n=8). Prospective studies (n=8) assessed quality of life before and after chemotherapy, physical therapy or pulmonary resection. The studies adopted different methodologies and provided conflicting results of quality of life. Cross-sectional studies with comparatively healthy subjects found an inferior quality of life for people with lung cancer. Conclusion: The scoping review contributed to the identification of the multiple evaluated instruments, both generic and specific. It found a lack of homogeneity in the methodological approaches of the studies. Further prospective studies with a specific instrument and methodological standardization to evaluate the quality of life of people with lung cancer are recommended.

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Factors associated with frailty in older adults

Cited by 67 publications

References 31 publications

Effect of Frailty on Outcome after Traumatic Spinal Cord Injury

Effect of Frailty on Outcome after Traumatic Spinal Cord Injury

Mastication and oral sensory function in frail edentulous elderly: a case–control study

Quality of life of patients with lung cancer: A scoping review

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