2011
DOI: 10.1159/000331339
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Abstract: Molecular profiling has fundamentally changed our understanding of breast cancer in the last 10 years, by creating a new taxonomy of breast cancers based on the expression patterns of so-called ‘intrinsic genes’. Hierarchical clustering analyses performed on microarray-based gene expression profiles of breast cancers defined distinct breast cancer subgroups (luminal type A/B, HER2-enriched type, basal-like type). Since the initial landmark study by Perou et al., the concept of intrinsic breast cancer subtypes … Show more

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Cited by 46 publications
(29 citation statements)
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References 50 publications
(71 reference statements)
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“…Currently, results of genetic testing methods for breast cancer are inconclusive. Breast cancer is usually divided into four subtypes according to immunohistochemical indicators commonly used in clinical practice: Her-2 overexpression, luminal A, luminal B and basal-like subtypes (7,8). This study showed that luminal A-type had the highest constituent ratio in 892 cases of invasive breast cancer patients, while luminal B-type had the lowest constituent ratio; findings that are consistent with the results of previous studies (9)(10)(11)(12).…”
Section: Discussionsupporting
confidence: 91%
“…Currently, results of genetic testing methods for breast cancer are inconclusive. Breast cancer is usually divided into four subtypes according to immunohistochemical indicators commonly used in clinical practice: Her-2 overexpression, luminal A, luminal B and basal-like subtypes (7,8). This study showed that luminal A-type had the highest constituent ratio in 892 cases of invasive breast cancer patients, while luminal B-type had the lowest constituent ratio; findings that are consistent with the results of previous studies (9)(10)(11)(12).…”
Section: Discussionsupporting
confidence: 91%
“…The mean age of patients was 50.73±10.28 years (range from 27 to 80 years). Of the 1,086 patients, 544 were with Luminal A tumors and 135 with Luminal B tumors, 102 were with HER2-enriched type tumors, and 305 were with basal-like type tumors [12]. The criteria to include a patient in the present study were as follows: (1) curative operations were performed; (2) resected specimens were pathologically examined; (3) more than 10 lymph nodes were pathologically examined after the operation; and (4) a complete medical record including the status of ER, PR, Her2, p53, and Ki67 was available.…”
Section: Methodsmentioning
confidence: 99%
“…Gene expression profiling based on the expression of specific receptors, such as estrogen receptor (ER), progesterone receptor (PR) and human epithelial growth factor receptor-2 (HER2) receptor, classifies BC into 4 distinct subtypes: luminal A, luminal B, HER2-positive and basal-like BC. Knowledge of the expression of these receptors is required to determine the eligibility of BC patients for endocrine therapies [1]. Although systemic therapies based on hormones, cytotoxic agents or target antibodies are frequently effective in controlling tumor growth and progression, BC patients who initially respond to these therapies can develop resistance to them at a later date [2].…”
mentioning
confidence: 99%