Amantadine and &lt;i&gt;L&lt;/i&gt;-Carnitine Treatment of Chronic Fatigue Syndrome

Plioplys, Audrius V.; Plioplys, Sigita

doi:10.1159/000119325

Cited by 75 publications

(59 citation statements)

References 17 publications

(25 reference statements)

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“…Oral L-carnitine was recently tested in patients with narcolepsy and shown to reduce their excessive daytime sleepiness (45). Similarly low serum acylcarnitine levels have been measured in patients with chronic fatigue syndrome (46), another condition with reported sleep problems (47), and L-carnitine administration has also shown some benefit in reducing fatigue (48). These studies support the growing evidence from mutant mice studies that altered fatty acid metabolism affects sleep signaling (49).…”

Section: Discussionmentioning

confidence: 65%

Effect of sleep deprivation on the human metabolome

Davies

Ang

Revell

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

399

336

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Sleep restriction and circadian clock disruption are associated with metabolic disorders such as obesity, insulin resistance, and diabetes. The metabolic pathways involved in human sleep, however, have yet to be investigated with the use of a metabolomics approach. Here we have used untargeted and targeted liquid chromatography (LC)/MS metabolomics to examine the effect of acute sleep deprivation on plasma metabolite rhythms. Twelve healthy young male subjects remained in controlled laboratory conditions with respect to environmental light, sleep, meals, and posture during a 24-h wake/ sleep cycle, followed by 24 h of wakefulness. Two-hourly plasma samples collected over the 48 h period were analyzed by LC/MS. Principal component analysis revealed a clear time of day variation with a significant cosine fit during the wake/sleep cycle and during 24 h of wakefulness in untargeted and targeted analysis. Of 171 metabolites quantified, daily rhythms were observed in the majority (n = 109), with 78 of these maintaining their rhythmicity during 24 h of wakefulness, most with reduced amplitude (n = 66). During sleep deprivation, 27 metabolites (tryptophan, serotonin, taurine, 8 acylcarnitines, 13 glycerophospholipids, and 3 sphingolipids) exhibited significantly increased levels compared with during sleep. The increased levels of serotonin, tryptophan, and taurine may explain the antidepressive effect of acute sleep deprivation and deserve further study. This report, to our knowledge the first of metabolic profiling during sleep and sleep deprivation and characterization of 24 h rhythms under these conditions, offers a novel view of human sleep/wake regulation.circadian rhythms | total sleep deprivation | melatonin | depression | biomarker C ircadian clocks control the timing of most daily biological processes, including cyclic changes in metabolism and the sleep/wake cycle (1). There is a clear link between the circadian timing system and metabolism (2-4), with disrupted circadian rhythms, sleep restriction, and sleep deprivation associated with metabolic disorders (obesity, insulin resistance, diabetes) and cardiovascular disease (5-8). The underlying mechanisms linking metabolic disease, circadian clock misalignment, and sleep restriction are the subject of current research, elucidation of which will require a global "systems" approach (9). Transcriptomic studies have shown that rhythmic gene expression may be affected by sleep restriction, sleep deprivation, and mistimed sleep (10-12), but, as yet, no studies have directly investigated the effect that sleep and sleep deprivation may have on the metabolic profile. Metabolic profiling, or "metabolomics," is the profiling of small-molecule metabolites and offers the potential to characterize specific metabolic phenotypes associated with disrupted circadian timing and sleep loss. Metabolomics has an advantage over other "omics" techniques, in that it directly samples the metabolic changes in an organism and integrates information from changes at the gene, transcript, an...

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Section: Discussionmentioning

confidence: 65%

Effect of sleep deprivation on the human metabolome

Davies

Ang

Revell

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

399

336

View full text Add to dashboard Cite

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“…Our observations of decreased carnitine levels in CFS patients suggest that Lcamitine may be an appropriate treatment of CFS pa tients. L-camitine has been shown to reduce the lethargy and fatigue in a number of different chronic neurologic diseases processes [23,24], Preliminary results have sug gested clinical improvement in CFS patients with this treatment approach [24],…”

mentioning

confidence: 99%

Serum Levels of Carnitine in Chronic Fatigue Syndrome: Clinical Correlates

Plioplys¹,

Plioplys

1995

Neuropsychobiology

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Carnitine is essential for mitochondrial energy production. Disturbance in mitochondrial function may contribute to or cause the fatigue seen in chronic fatigue syndrome (CFS) patients. One previous investigation has reported decreased acylcarnitine levels in 38 CFS patients. We investigated 35 CFS patients (27 females and 8 males); our results indicate that CFS patients have statistically significantly lower serum total carnitine, free carnitine and acylcarnitine levels, not only lower acylcarnitine levels as previously reported. We also found a statistically significant correlation between serum levels of total and free carnitine and clinical symptomatology. Higher serum carnitine levels correlated with better functional capacity. These findings may be indicative of mitochondrial dysfunction, which may contribute to or cause symptoms of fatigue in CFS patients.

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“…Finalmente, respecto a la aplicabilidad de la suplementación de la Lcarnitina, algunos estudios sugieren que podría actuar en la reducción de calambres y el aumento de la sensación de bienestar y calidad de vida 27 , así como en el tratamiento del síndrome de la fatiga crónica 28 . Por lo tanto, se sugiere que futuros estudios deban incluir grupos de placebo en los experimentos, variables como el VO 2 máximo, umbral de lactato, así como la necesidad de considerar el grado de crecimiento y maduración de los animales a estudiar CONCLUSIÓN A través de los resultados obtenidos, se puede concluir que la suplementación en animales sedentarios y entrenados con L-carnitina aumentó el tiempo necesario para la reducción de la fuerza (fatiga) a nivel del músculo gastrocnemio, sugiriendo que la L-carnitina desempeña un importante papel en el proceso de contracción muscular y por ende, mejora el desempeño del trabajo prolongado.…”

Section: Discussionunclassified

Efectos de la suplementación de carnitina sobre el nivel de fatiga muscular del gastrocnemio de ratas entrenadas y sedentárias

Gomez

Arruda

Ramos

et al. 2012

Rev. Bras. Cineantropom. Desempenho Hum.

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BY Efectos de la suplementación de carnitina sobre el nivel de fatiga muscular del gastrocnemio de ratas entrenadas y sedentarias Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary ratsRossana Gomez Campos Resumo -La L-carnitina tiene un gran valor en procesos metabólicos al cumplir un papel importante en el proceso de β-oxidación mitocondrial, por lo cual, podría ser usada para mejorar el rendimiento atlético y mantener una carga de trabajo. Este trabajo tuvo por objetivo evaluar los efectos de la suplementación de L-carnitina y del entrenamiento en el tiempo necesario a la inducción de la fatiga muscular en preparaciones in situ del nervio ciático y músculo gastronemio en ratas. Cuatro grupos de animales fueron constituidos: sedentario no suplementado (SNS), sedentario suplementado (SS), entrenado no suplementado (ENS) y entrenado suplementado (ES). El entrenamiento fue realizado en sesiones diarias (1h/5dias/semana) y con suplementación oral crónica de L-Carnitina (1mg/ml) por 4 semanas. La fatiga muscular fue obtenida mediante estimulación supramaximal tetánica del nervio ciático (50 Hz). Los valores del tiempo para la reducción de fuerza fueron significativamente diferentes (p<0,05) entre los grupos SNS vs SS y ENS vs ES, respectivamente. Sin embargo, no hubo diferencias significativas entre los grupos ES vs SS y ENS vs SNS. Estos resultados demuestran que la L-carnitina prolongo el tiempo necesario para la reducción de fuerza a nivel del músculo gastrocnemio.

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Amantadine and <i>L</i>-Carnitine Treatment of Chronic Fatigue Syndrome

Cited by 75 publications

References 17 publications

Effect of sleep deprivation on the human metabolome

Effect of sleep deprivation on the human metabolome

Serum Levels of Carnitine in Chronic Fatigue Syndrome: Clinical Correlates

Efectos de la suplementación de carnitina sobre el nivel de fatiga muscular del gastrocnemio de ratas entrenadas y sedentárias

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