2002
DOI: 10.1159/000064279
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Abstract: Infection, mainly related to vascular access, is one of the main causes of morbidity and a preventable cause of death in hemodialysis patients. From January 1994 to April 1998 we conducted a prospective study to assess the incidence and risk factors of catheter-related bacteremia. One hundred and twenty-nine tunneled dual-lumen hemodialysis catheters were inserted percutaneously into the internal jugular vein in 89 patients. Bacteremia (n = 56) occurred at least once with 37 (29%) of the catheters (an incidenc… Show more

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Cited by 110 publications
(96 citation statements)
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References 30 publications
(35 reference statements)
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“…An updated mortality curve for cardiovascular disease and infection in 127 Italian CHD patients subdivided according to the presence or not of the C282Y and H63D HFE mutations is shown in figure 1. It is worthy of note that, in patients negative for HFE mutations, we observed a higher mortality due to sepsis, previously associated with a higher iron dosage (Jean, Charra et al 2002;Teehan, Bahdouch et al 2004), and due to cardiovascular disease, possibly linked to hypertension and thromboembolic events related to ESAs (Miyashita, Tojo et al 2004;Phrommintikul, Haas et al 2007) and oxidative stress related to iron (Valenti, Valenti et al 2007). Fig.…”
Section: Hfe Mutations and Survivalmentioning
confidence: 51%
See 1 more Smart Citation
“…An updated mortality curve for cardiovascular disease and infection in 127 Italian CHD patients subdivided according to the presence or not of the C282Y and H63D HFE mutations is shown in figure 1. It is worthy of note that, in patients negative for HFE mutations, we observed a higher mortality due to sepsis, previously associated with a higher iron dosage (Jean, Charra et al 2002;Teehan, Bahdouch et al 2004), and due to cardiovascular disease, possibly linked to hypertension and thromboembolic events related to ESAs (Miyashita, Tojo et al 2004;Phrommintikul, Haas et al 2007) and oxidative stress related to iron (Valenti, Valenti et al 2007). Fig.…”
Section: Hfe Mutations and Survivalmentioning
confidence: 51%
“…As mentioned above, although treatment with ESAs and IV iron formulations (Locatelli, Aljama et al 2004) are generally prescribed, functional iron deficiency is a common finding, determining the need for high doses of ESAs and iron, both associated with adverse events. Indeed, high ESAs doses have been associated with mortality due to cardiovascular events related to hypertension and hypercoagulability (Miyashita, Tojo et al 2004;Phrommintikul, Haas et al 2007;Strippoli, Tognoni et al 2007), whereas excess iron promotes vascular damage by inducing oxidative stress, and heightens the risk of infections (Seifert, von Herrath et al 1987;Jean, Charra et al 2002;Teehan, Bahdouch et al 2004;Kalantar-Zadeh, Regidor et al 2005;Valenti, Valenti et al 2007). The mechanism proposed to explain refractoriness to IV iron was previously related to the inhibition of erythropoiesis and iron recycling from macrophages by inflammation (Stenvinkel 2003).…”
Section: Role Of Hepcidin In Anemia Of Esrdmentioning
confidence: 99%
“…Additionally, a significantly larger proportion of patients in the symmetrical-tip catheter group had metabolic disorders compared with the step-tip catheter group, which may have affected the study outcomes. However, although some research suggests that diabetes is associated with an increased risk of catheter-related infection, 26 there are counter examples reporting that diabetes is not a significant independent risk factor for catheter-related infection. 15,27,28 Despite these limitations, our findings provide a valuable contribution to the existing literature supporting the use of symmetrical-tip catheters for chronic hemodialysis, and provide the first report of symmetrical-tip catheter use in China.…”
Section: 14mentioning
confidence: 99%
“…Functional iron deficiency is a common finding, determining the need for high doses of ESAs and iron, both associated with adverse events. High doses of ESAs increase the risk of mortality due to cardiovascular events related to hypertension and hypercoagulability (9 -11), whereas excess iron promotes vascular damage by inducing oxidative stress and heightens the risk of infections (12)(13)(14)(15)(16). The mechanism proposed to explain refractoriness to i.v.…”
mentioning
confidence: 99%