2021
DOI: 10.1155/2021/2678134
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Abstract: Deletion of pannexin-1 (Panx-1) leads not only to a reduction in endothelium-derived hyperpolarization but also to an increase in NO-mediated vasodilation. Therefore, we evaluated the participation of Panx-1-formed channels in the control of membrane potential and [Ca2+]i of endothelial cells. Changes in NO-mediated vasodilation, membrane potential, superoxide anion (O2⋅–) formation, and endothelial cell [Ca2+]i were analyzed in rat isolated mesenteric arterial beds and primary cultures of mesenteric endotheli… Show more

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Cited by 9 publications
(12 citation statements)
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“…Similar results have been found in mesenteric rat vessels, where general blockers of Panx-1 channels promote endothelial superoxide production by activating endothelial NADP(H)oxidase [70]. Endothelial TTX-sensitive Na v channels and Ca v 3.2 channels mediate endothelial depolarization and this superoxide production, promoting an increase in NO-mediated vasorelaxation via NADPH oxidase-dependent eNOS phosphorylation at serine 1177 [70]. On the other hand, the prolonged activation of Panx-1 channels by Calcitonin Gene-Related Peptide (CGRP) receptor stimulation leads to a Panx-1-formed channel opening and the ensuing superoxide-dependent connexin-based hemichannel activation exclusively in ECs [69].…”
Section: Pannexin Proteins In Arteriolessupporting
confidence: 85%
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“…Similar results have been found in mesenteric rat vessels, where general blockers of Panx-1 channels promote endothelial superoxide production by activating endothelial NADP(H)oxidase [70]. Endothelial TTX-sensitive Na v channels and Ca v 3.2 channels mediate endothelial depolarization and this superoxide production, promoting an increase in NO-mediated vasorelaxation via NADPH oxidase-dependent eNOS phosphorylation at serine 1177 [70]. On the other hand, the prolonged activation of Panx-1 channels by Calcitonin Gene-Related Peptide (CGRP) receptor stimulation leads to a Panx-1-formed channel opening and the ensuing superoxide-dependent connexin-based hemichannel activation exclusively in ECs [69].…”
Section: Pannexin Proteins In Arteriolessupporting
confidence: 85%
“…Nevertheless, although the EDH-mediated vasodilator pathway is reduced in Panx-1 knockout mice, the NO-dependent vasodilator component is enhanced in these animals, indicating that endothelial Panx-1 may be involved in the tonic regulation of NO production by eNOS. Similar results have been found in mesenteric rat vessels, where general blockers of Panx-1 channels promote endothelial superoxide production by activating endothelial NADP(H)oxidase [70]. Endothelial TTX-sensitive Na v channels and Ca v 3.2 channels mediate endothelial depolarization and this superoxide production, promoting an increase in NO-mediated vasorelaxation via NADPH oxidase-dependent eNOS phosphorylation at serine 1177 [70].…”
Section: Pannexin Proteins In Arteriolessupporting
confidence: 79%
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“…In both HT29 and HepG2 cells, the addition of ATP to the culture medium, together with Quercetin, did not restore the migration rate [ 27 ]. The inhibition of the migration rate induced by Probenecid in HT29 (not restored by ATP) and the decrease in the pAKT/AKT ratio might suggest some effect of Probenecid on this system as reported by different other studies [ 58 , 59 ].…”
Section: Discussionsupporting
confidence: 53%