2013
DOI: 10.1155/2013/162750
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Abstract: There has been increasing interest in the research on flavonoids from plant sources because of their versatile health benefits reported in various epidemiological studies. Since flavonoids are directly associated with human dietary ingredients and health, there is need to evaluate structure and function relationship. The bioavailability, metabolism, and biological activity of flavonoids depend upon the configuration, total number of hydroxyl groups, and substitution of functional groups about their nuclear str… Show more

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Cited by 2,995 publications
(2,331 citation statements)
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References 132 publications
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“…The PaM capability of lowering concentration of MDA and 8OHdG is attributable to its flavonoids constituent. There are growing evidences that consumption of antioxidant regularly is able to postpone even prevent degenerative diseases including cardiovascular, cancer, Parkinson's Disease (PD) and Alzheimer's dementia, and other age related diseases 23,40,41 . Because of their lower redox potentials, flavonoids are thermodynamically able to reduce highly oxidizing free radicals (redox potentials ranging from 2.13-1.0 V) such as superoxide, peroxyl, alkoxyl, and hydroxyl radicals by hydrogen atom donation 23 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The PaM capability of lowering concentration of MDA and 8OHdG is attributable to its flavonoids constituent. There are growing evidences that consumption of antioxidant regularly is able to postpone even prevent degenerative diseases including cardiovascular, cancer, Parkinson's Disease (PD) and Alzheimer's dementia, and other age related diseases 23,40,41 . Because of their lower redox potentials, flavonoids are thermodynamically able to reduce highly oxidizing free radicals (redox potentials ranging from 2.13-1.0 V) such as superoxide, peroxyl, alkoxyl, and hydroxyl radicals by hydrogen atom donation 23 .…”
Section: Discussionmentioning
confidence: 99%
“…Suppression of ROS formation can be performed either by inhibition of enzymes or by chelating trace elements involved in free radical generation. Another action of antioxidant flavonoids to reduce ROS concentration is through scavenging ROS, and up regulation of antioxidant defenses 22,23 . Decrease in ROS formation, followed by increase in activity of enzymatic antioxidant defenses such as SOD and CAT, leading to pro-oxidant antioxidant balance, providing the cellular damages due to oxidative stress an opportunity to undertake denovo formation for self-repair.…”
mentioning
confidence: 99%
“…The structural features of flavonoids are many responsible for influence of several mechanisms toward antioxidant activity such as radical scavenging and metal ion chelation ability. [9,10] There are many mechanisms for antioxidant action, which mainly includes suppression of reactive oxygen species (ROS) formation either by inhibition of enzymes or by chelating trace elements involved in free radical generation, scavenging ROS, and upregulation or protection of antioxidant defenses. [11] Flavonoids inhibit the enzymes involved in ROS generation, that is, microsomal monooxygenase, glutathione S-transferase, mitochondrial succinoxidase, and nicotinamide adenine dinucleotide hydrate oxidase, mainly affecting on the function of enzyme systems critically involved in the generation of inflammatory processes, especially tyrosine and serinethreonine protein kinases.…”
Section: Introductionmentioning
confidence: 99%
“…Flavonoids are a class of secondary plant phenolics with significant antioxidant and chelating properties 11 . Flavonoids contributes towards biological activities like antibacterial, anticancer, antiinflammatory, antiviral and hepatoprotective 12 . Quercetin is a plant pigment, abundantly occurs in many ethnic plants, especially onion and tea, therefore, a sufficient amount may be consumed daily.…”
Section: Introductionmentioning
confidence: 99%