Blood gas calculator.

Severinghaus, John W.

doi:10.1152/jappl.1966.21.3.1108

Cited by 897 publications

(297 citation statements)

References 21 publications

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“…Alternatively, the Severinghaus (1966) slide rule can be used. The slide rule offers a simple method in which P 50 is estimated by aligning PO 2 on one scale with saturation on another.…”

Section: Equationmentioning

confidence: 99%

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The in-vivo oxyhaemoglobin dissociation curve at sea level and high altitude

Balaban

Duffin

Preiss

et al. 2013

Respiratory Physiology & Neurobiology

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Some animals have adapted to hypoxia by increasing their haemoglobin affinity for oxygen, but in vitro studies have not shown any change of haemoglobin affinity for oxygen in human high altitude natives or lowlanders acutely acclimatized to high altitude. We conducted the first in vivo study of the oxyhaemoglobin dissociation curve by progressively reducing arterial PO 2 while maintaining normocapnia in lowlanders at sea level, lowlanders sojourning at 3600m for two weeks and native Andeans at the same altitude. We found that the in vivo PO 2 at which haemoglobin is half-saturated (P 50 ) is higher in lowlanders at sea level (32 mmHg) than that measured in vitro (27 mmHg) and that lowlanders and highlanders do significantly increase the in vivo affinity of their haemoglobin for oxygen with exposure to high altitude. These results indicate the value of an in vivo approach for studying the oxyhaemoglobin dissociation curve.iii

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“…Alternatively, the Severinghaus (1966) slide rule can be used. The slide rule offers a simple method in which P 50 is estimated by aligning PO 2 on one scale with saturation on another.…”

Section: Equationmentioning

confidence: 99%

“…In order to determine how our in vivo SO 2 data compared to predictions based on previous in vitro studies, we then compared our in vivo SO 2 results to those calculated using the Severinghaus (1966) and Kelman (1966) methods. shown above.…”

Section: Comparison Of Measured So 2 Values With Those Of Severinghaumentioning

confidence: 99%

The in-vivo oxyhaemoglobin dissociation curve at sea level and high altitude

Balaban

Duffin

Preiss

et al. 2013

Respiratory Physiology & Neurobiology

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“…Saturation of oxygen was calculated using the method described by Severinghaus. 7 We assumed Pc% to equal the calculated PAo2, Mean pulmonary-thoracic static compliance (CLT) was calculated using the equation, where APx is the change in airway pressure induced by the mechanically delivered tidal volume "x" in ml.…”

Section: Methodsmentioning

confidence: 99%

Nitrous oxide administration in the presence of subcutaneous emphysema: An experimental model

Poulton

Haldeman²,

Munson

1982

Canad. Anaesth. Soc. J.

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Adverse effects may occur when patients with air in the pleural space or in the cerebral ventricles breathe nitrous oxide. We developed an animal model to learn whether similar adverse effects are associated with the inhalation of nitrous oxide when air is present in the subcutaneous space. We induced extensive subcutaneous emphysema in swine and measured oxygen and carbon dioxide tensions in systemic arterial and mixed venous blood; cardiac output; intravaseular, airway, and pre-sternal subcutaneous pressures; total pulmonary-thoracic static compliance; and thoracic girth before and after a 45 minute period of breathing 75 per cent nitrous oxide in oxygen. Cardiac output decreased from 3.13 ---0.51 I/min to 2.40 -+ 0.62 l/rain (p < 0.05); no other values changed significantly. No significant adverse cardiorespiratory effects resulted from the transfer of inhaled nitrous oxide to the subcutaneous space in this animal model. KEY WORDS: ANAESTHETICS, GASES, nitrous oxide; COMPLICATIONS, subcutaneous emphysema.ALTHOUGH air-filled cavities in the body tend to decrease in size and to disappear spontaneously, during the inhalation of nitrous oxide the spaces increase in size until an equilibrium occurs. induced by nitrous oxide in swine with subcutaneous emphysema. METHODSTen young swine weighing 20-25 kg were anaesthetized with intramuscular ketamine hydrochloride 20 mg-kg -I. A catheter for the administration of fluids and drugs was inserted into a vein of the ear, the trachea was intubated and anaesthesia and immobilization were maintained with intravenous thiamylal and pancuronium bromide. The lungs were ventilated with air from a time-cycled volume ventilator, maintaining Pact2 between 4.9 and 5.7 kPa (37 and 43 ton). Body temperature was monitored by a pulmonary artery thermistor and was maintained at 37.0 ---I~ by external infrared heating. A Swan-Ganz | thermodilution catheter was placed into the pulmonary artery through a high cervical jugular venous cutdown. Each animal received lactated Ringer's solution, 2-3 ml.kg-I/hour to maintain hydration.An 18-gauge Teflon | catheter was placed surgically into the carotid artery and a 12-gauge plastic catheter was placed into the subcutaneous tissue anterior to the sternum. Pressures from the arterial and central venous catheters, from the subcutaneous space and from the airway were transduced with a high fidelity pressure measurement

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“…It has been well known that f or d log P02/d T is not constant and varies with P0237 or Sot (HEDLEY-WHITE and LAYER, 1964;NUNN et al, 1965;SEVERINGHAUS, 1966). Several algorithms for the calculation off from P0237 or S02T have been reported, which are derived from the data of NUNN et al (1965) and values calculated by SEVERINGHAUS (1966).…”

Section: Symbols and Definitionsmentioning

confidence: 99%

“…Several algorithms for the calculation off from P0237 or S02T have been reported, which are derived from the data of NUNN et al (1965) and values calculated by SEVERINGHAUS (1966). However there are wide differences between the data of NUNN et al and values calculated by Severinghaus, especially in P02 values around 120 mmHg (LABEL, 1980).…”

Section: Symbols and Definitionsmentioning

confidence: 99%

New equations to calculate temperature correction factors for Po2 in human blood.

Inaba¹,

Ohwada²,

Sato³

et al. 1986

Jpn.J.Physiol

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Effects of hemoglobin concentration (Hb), pH, and body temperature (T) on the relationships between d log Poz/d T and Pot were studied by means of a mathematical model using a Newton-Raphson iteration method. The functions between d log Poz/d T and Poz were affected by the above three factors. New equations considering the effects of Hb, pH, and T were proposed by modifying the equation reported by Severinghaus: where fB is the Bohr factor. The above equations provided values of d log Poz/d T which fit closely to those obtained by the complex iteration method with maximum differences of less than 1.3 x 10 -3 at T= 27, indicating that maximum errors for Poz at T (PozT) are less than 3.0°c at T=27 and that our equations can be applied over a wide range of Hb, pH37 and T.

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Blood gas calculator.

Cited by 897 publications

References 21 publications

The in-vivo oxyhaemoglobin dissociation curve at sea level and high altitude

The in-vivo oxyhaemoglobin dissociation curve at sea level and high altitude

Nitrous oxide administration in the presence of subcutaneous emphysema: An experimental model

New equations to calculate temperature correction factors for Po2 in human blood.

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