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Cited by 310 publications
(137 citation statements)
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“…DNA fragmentation may have previously fallen below the threshold of standard methods of detection, since dying cells need only form a small percentage of total tissue mass (an estimated 2 ± 3%) to obtain substantial daily regression of tissue (Bursch et al, 1990). It is likely that the nucleosomal ladders observed with LMPCR are derived from apoptotic cell death accompanying homeostatic regulation (Hinsull and Bellamy, 1981) since none of the tissues examined underwent experimental manipulation prior to isolation of DNA.…”
Section: Discussionmentioning
confidence: 99%
“…DNA fragmentation may have previously fallen below the threshold of standard methods of detection, since dying cells need only form a small percentage of total tissue mass (an estimated 2 ± 3%) to obtain substantial daily regression of tissue (Bursch et al, 1990). It is likely that the nucleosomal ladders observed with LMPCR are derived from apoptotic cell death accompanying homeostatic regulation (Hinsull and Bellamy, 1981) since none of the tissues examined underwent experimental manipulation prior to isolation of DNA.…”
Section: Discussionmentioning
confidence: 99%
“…Apoptosis is characterized by preservation of membrane integrity, cytoplasmic and nuclear condensation, diminution of cellular volume, plasma membrane bleb formation, and morphological preservation of organellar structure. The cell eventually fragments into apoptotic bodies that are engulfed by neighboring cells and degraded (Bursch et al, 1990;Cohen, 1993;Schwartzman and Cidlowski, 1993). During apoptosis, morphological changes often are accompanied by internucleosomal cleavage of genomic DNA (Wyllie, 1980;Compton, 1992).…”
mentioning
confidence: 99%
“…It has been suggested that the apoptotic process is complete within several hours. 34 In this trial, samples were collected 24 hours after the fourth of the five consecutive daily administrations within a cycle, a time that may have caused us to underestimate the degree of the apoptosis induced by rAd-p53 SCH 58500.…”
Section: Discussionmentioning
confidence: 99%