Mitochondrial production of reactive oxygen species

Grivennikova, Vera G.; Vinogradov, Andrei D.

doi:10.1134/s0006297913130087

Cited by 68 publications

(39 citation statements)

References 233 publications

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“…We cannot rule out that HCV and its core protein exploit this mechanism to inhibit complex I activity since they are known to induce NO synthase with concomitant production of NO, at least in non-liver cells [99]. Nevertheless, other calcium-dependent ROS-producing enzymes in mitochondria should be considered such as α-ketoglutarate dehydrogenase (α-KGDH) and pyruvate dehydrogenase (PHD) that are located in mitochondrial matrix [100, 101]. These enzymes are known to produce hydrogen peroxide as well as superoxide.…”

Section: Hepatitis C Virusmentioning

confidence: 99%

Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

et al. 2016

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Virally induced liver cancer usually evolves over long periods of time in the context of a strongly oxidative microenvironment, characterized by chronic liver inflammation and regeneration processes. They ultimately lead to oncogenic mutations in many cellular signaling cascades that drive cell growth and proliferation. Oxidative stress, induced by hepatitis viruses, therefore is one of the factors that drives the neoplastic transformation process in the liver. This review summarizes current knowledge on oxidative stress and oxidative stress responses induced by human hepatitis B and C viruses. It focuses on the molecular mechanisms by which these viruses activate cellular enzymes/systems that generate or scavenge reactive oxygen species (ROS) and control cellular redox homeostasis. The impact of an altered cellular redox homeostasis on the initiation and establishment of chronic viral infection, as well as on the course and outcome of liver fibrosis and hepatocarcinogenesis will be discussed The review neither discusses reactive nitrogen species, although their metabolism is interferes with that of ROS, nor antioxidants as potential therapeutic remedies against viral infections, both subjects meriting an independent review.

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Section: Hepatitis C Virusmentioning

confidence: 99%

Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

et al. 2016

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“…The in vivo contribution to the production of ROS by other mitochondrial dehydrogenases, e.g. α-glycerophosphate dehydrogenase, is also linked to the ratio of NADH/NAD + (Adam-Vizi and Tretter, 2013;Grivennikova and Vinogradov, 2013). As far as I know, the role of DLDH or any of the other dehydrogenases in responding directly to environmentally induced oxidative stress has not been the focus of any study to date.…”

Section: Sites Of Ros Production In Mitochondriamentioning

confidence: 99%

“…In order for other molecules, whose outer electrons are paired and have an opposite spin, to react with oxygen, one electron would have to be paired with an electron of the same spin, an energetically unfavorable process. This barrier can be overcome by adding the electrons one at a time (Fridovich, 1998;Grivennikova and Vinogradov, 2013;Halliwell and Gutteridge, 2007). This slows the reaction, creates chemical inertness and contributes to the accumulation of oxygen in the atmosphere.…”

Section: Rosmentioning

confidence: 99%

Proteomic responses to environmentally induced oxidative stress

Tomanek

2015

Journal of Experimental Biology

132

130

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Environmental (acute and chronic temperature, osmotic, hypoxic and pH) stress challenges the cellular redox balance and can lead to the increased production of reactive oxygen species (ROS). This review provides an overview of the reactions producing and scavenging ROS in the mitochondria, endoplasmic reticulum (ER) and peroxisome. It then compares these reactions with the findings of a number of studies investigating the proteomic responses of marine organisms to environmentally induced oxidative stress. These responses indicate that the thioredoxin-peroxiredoxin system is possibly more frequently recruited to scavenge H 2 O 2 than the glutathione system. Isoforms of superoxide dismutase (SOD) are not ubiquitously induced in parallel, suggesting that SOD scavenging activity is sometimes sufficient. The glutathione system plays an important role in some organisms and probably also contributes to protecting protein thiols during environmental stress. Synthesis pathways of cysteine and selenocysteine, building blocks for glutathione and glutathione peroxidase, also play an important role in scavenging ROS during stress. The increased abundance of glutaredoxin and DyP-type peroxidase suggests a need for regulating the deglutathionylation of proteins and scavenging of peroxynitrite. Reducing equivalents for these scavenging reactions are generated by proteins of the pentose phosphate pathway and by NADP-dependent isocitrate dehydrogenase. Furthermore, proteins representing reactions of the tricarboxylic acid cycle and the electron transport system generating NADH and ROS, including those of complex I, II and III, are frequently reduced in abundance with stress. Protein maturation in the ER likely represents another source of ROS during environmental stress, as indicated by simultaneous changes in ER chaperones and antioxidant proteins. Although there are still too few proteomic analyses of non-model organisms exposed to environmental stress for a general pattern to emerge, hyposaline and low pH stress show different responses from temperature and hypoxic stress. Furthermore, comparisons of closely related congeners differing in stress tolerance start to provide insights into biochemical processes contributing to adaptive differences, but more of these comparisons are needed to draw general conclusions. To fully take advantage of a systems approach, studies with longer time courses, including several tissues and more species comparisons are needed.

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“…Mitochondria together with several other eukaryotic cellular compartments such as plasma membrane [4, 5], cytosol [6, 7], peroxisomes, lysosomes [8], and endoplasmic reticulum (ER) [9, 10] significantly participate in ROS production and its consequent utilization [11]. In mitochondria during aerobic metabolism, the reduction of excessive electronegative oxygen atoms leads to the formation of reactive intermediates such as superoxide that can easily be converted to various forms of ROS.…”

Section: Introductionmentioning

confidence: 99%

The Central Role of Biometals Maintains Oxidative Balance in the Context of Metabolic and Neurodegenerative Disorders

Pokusa

Trančiková

2017

Oxidative Medicine and Cellular Longevity

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Traditionally, oxidative stress as a biological aspect is defined as an imbalance between the free radical generation and antioxidant capacity of living systems. The intracellular imbalance of ions, disturbance in membrane dynamics, hypoxic conditions, and dysregulation of gene expression are all molecular pathogenic mechanisms closely associated with oxidative stress and underpin systemic changes in the body. These also include aspects such as chronic immune system activation, the impairment of cellular structure renewal, and alterations in the character of the endocrine secretion of diverse tissues. All of these mentioned features are crucial for the correct function of the various tissue types in the body. In the present review, we summarize current knowledge about the common roots of metabolic and neurodegenerative disorders induced by oxidative stress. We discuss these common roots with regard to the way that (1) the respective metal ions are involved in the maintenance of oxidative balance and (2) the metabolic and signaling disturbances of the most important biometals, such as Mg2+, Zn2+, Se2+, Fe2+, or Cu2+, can be considered as the central connection point between the pathogenesis of both types of disorders and oxidative stress.

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Mitochondrial production of reactive oxygen species

Cited by 68 publications

References 233 publications

Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

Proteomic responses to environmentally induced oxidative stress

The Central Role of Biometals Maintains Oxidative Balance in the Context of Metabolic and Neurodegenerative Disorders

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