1997
DOI: 10.1126/science.277.5334.2005
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Abstract: There is growing evidence that T helper cell subsets (TH1 and TH2) can be differentially recruited to promote different types of inflammatory reactions. Murine TH1 but not TH2 cells are recruited through P- and E-selectin into inflamed tissues, where they induce delayed-type hypersensitivity reactions. The human eotaxin-receptor CCR3, originally described on eosinophils and basophils, was also found to be expressed by TH2 cells. An antibody to CCR3 was used to isolate T cells from peripheral blood that give ri… Show more

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Cited by 988 publications
(698 citation statements)
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“…Thus, the RA memory Th1 cells have irreversibly become committed to their phenotype as previously reported to occur when Th1 and Th2 cells are repeatedly stimulated [27,28]. In contrast to the fixed cytokine phenotype, another way to phenotypically characterize Th1 and Th2 cells is by the use of the chemokine receptor expression [14,29]. In this report we demonstrate that the Th2-chemokine receptor CCR3 can be induced in polarized memory Th1 clones and polyclonal Th1-cell lines, even though their cytokine profile is not altered.…”
Section: Discussionmentioning
confidence: 86%
See 1 more Smart Citation
“…Thus, the RA memory Th1 cells have irreversibly become committed to their phenotype as previously reported to occur when Th1 and Th2 cells are repeatedly stimulated [27,28]. In contrast to the fixed cytokine phenotype, another way to phenotypically characterize Th1 and Th2 cells is by the use of the chemokine receptor expression [14,29]. In this report we demonstrate that the Th2-chemokine receptor CCR3 can be induced in polarized memory Th1 clones and polyclonal Th1-cell lines, even though their cytokine profile is not altered.…”
Section: Discussionmentioning
confidence: 86%
“…The different migratory properties of Th1 and Th2 cells relate to the expression of different chemokine receptors that are tightly regulated during their differentiation and activation processes [10,11]. Activated/memory Th1 cells have been shown to be associated with the expression of CCR5 (receptor for`Regulated upon Activation Normally T cell Expressed and Secreted' (RANTES), and`Macrophage Inflammatory Protein' (MIP-1a,-1b) and CXCR3 (receptor for`Interferon g Inducible Protein' (IP-10) and`Monokine Induced by IFNg' (MIG)) [12,13], while activated memory Th2 cells express the chemokine receptors CCR3 (receptor for Eotaxin) [14] and CCR4 (receptor for Thymus and Activation-Regulated Chemokine' (TARC)) [15].…”
Section: Introductionmentioning
confidence: 99%
“…A cellular or T helper (Th)1 response is associated with interferon-␥ production and macrophage activation, whereas a humoral or Th2 response is characterized by IL-4 and IL-5 production, B cell help and an antibody response. Chemokine receptors are markers for T helper subsets: CCR5 and CXCR3 are markers for Th1 cells [20,21], while CCR2 and CCR4 are expressed by Th2 cells [22,23]. Furthermore, ligands for CCR5 (CCL3, CCL4, and CCL5) have been shown to be chemotactic for Th1 and not Th2 cells [24].…”
Section: Chemokines Influence T Cell Fatementioning
confidence: 99%
“…Although eosinophil accumulation was not compared in WT versus Tbx21 2/2 mice, it has previously been reported that Ghanian pediatric patients with CM had uniformly low eosinophil counts because of tissue sequestration and destruction rather than decreased production during acute illness followed by eosinophilia 30 d after cure (48). Importantly, the eotaxin receptor is expressed by Th2 CD4 + T cells, and eotaxin is critical for the generation and maintenance of Th2 cells at allergenic sites and promotes the production of IL-4 and IL-5 (49,50). Therefore, it is likely that eotaxin participates in the amplification of the Th2 response observed in Tbx21 2/2 mice.…”
Section: Figurementioning
confidence: 99%