1989
DOI: 10.1126/science.2683083
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Abstract: Thymotaxin, an 11-kilodalton protein chemotactic for rat bone marrow hematopoietic precursors, was purified from media conditioned by a rat thymic epithelial cell line. The NH2-terminal sequence of thymotaxin was identical to that of rat beta 2-microglobulin (beta 2m). Antibodies to beta 2m removed thymotaxin activity from the fraction containing the 11-kilodalton protein. Chemotactic activity was observed with rat plasma beta 2m, human beta 2m, and mouse recombinant beta 2m, further supporting the identity of… Show more

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Cited by 63 publications
(18 citation statements)
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“…␤ 2 -microglobulin is another thymus stromal cell-derived molecule (albeit not a chemokine) that has been postulated to be involved in prothymocyte mobilization/recruitment (21)(22)(23). In addition, the variant isoforms of the CD44 integrin (CD44v), which appear to be expressed preferentially by hemopoietic progenitor cells, have recently been implicated in the recruitment and initial interaction of prothymocytes with the thymic stroma (24 -26).…”
Section: Discussionmentioning
confidence: 99%
“…␤ 2 -microglobulin is another thymus stromal cell-derived molecule (albeit not a chemokine) that has been postulated to be involved in prothymocyte mobilization/recruitment (21)(22)(23). In addition, the variant isoforms of the CD44 integrin (CD44v), which appear to be expressed preferentially by hemopoietic progenitor cells, have recently been implicated in the recruitment and initial interaction of prothymocytes with the thymic stroma (24 -26).…”
Section: Discussionmentioning
confidence: 99%
“…However, some surface features that are important for structure and/or function are conserved, including contact sites with other domains and two residues in a3 that interact with CD8. On this basis, there is an exposed patch in f32m which might be functionally significant (11,(36)(37)(38).…”
mentioning
confidence: 99%
“…Mice deficient in 02-m expression are deficient in MHC class I expression and are defective in developing cytotoxic T cells (33,66). ,2-m has additional functions, including binding to the Fc receptor in the neonatal intestine (59) and controlling migration of hemopoietic cells from bone marrow (8).…”
mentioning
confidence: 99%