2003
DOI: 10.1126/science.1081077
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Abstract: Gibberellin (GA) regulates growth and development in plants. We isolated and characterized a rice GA-insensitive dwarf mutant, gid2. The GID2 gene encodes a putative F-box protein, which interacted with the rice Skp1 homolog in a yeast two-hybrid assay. In gid2, a repressor for GA signaling, SLR1, was highly accumulated in a phosphorylated form and GA increased its concentration, whereas SLR1 was rapidly degraded by GA through ubiquitination in the wild type. We conclude that GID2 is a positive regulator of GA… Show more

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Cited by 573 publications
(557 citation statements)
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“…It is possible that the eui mutant plants accumulate high levels of bioactive GAs, and that the overproduction of bioactive GAs could feedback regulate GA signaling by decreasing the production of GID1 and GID2, since GA treatment reduced transcript abundance for all three GID1 genes of Arabidopsis [13]. Such high GA levels could also repress SLR1 expression as SLR1 protein accumulation was decreased or eliminated by GA treatment [5]. However, the proposed GA-mediated SLR1 transcription and relationship between these regulation events need more study [13], as SLR1 expression was not altered in the eui seedlings and aleurone cells compared with the WT in our current study.…”
Section: Discussionmentioning
confidence: 99%
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“…It is possible that the eui mutant plants accumulate high levels of bioactive GAs, and that the overproduction of bioactive GAs could feedback regulate GA signaling by decreasing the production of GID1 and GID2, since GA treatment reduced transcript abundance for all three GID1 genes of Arabidopsis [13]. Such high GA levels could also repress SLR1 expression as SLR1 protein accumulation was decreased or eliminated by GA treatment [5]. However, the proposed GA-mediated SLR1 transcription and relationship between these regulation events need more study [13], as SLR1 expression was not altered in the eui seedlings and aleurone cells compared with the WT in our current study.…”
Section: Discussionmentioning
confidence: 99%
“…Results are representative of two independent experiments with similar results. Figure 4A, the expression of the positive GA signaling genes, the receptor gene GID1 [11] and the F-box gene GID2 [5] was repressed in the eui mutant and increased in Eui-OX plants. Intriguingly, the negative GA regulator SLR1, which encodes a DELLA protein [3], was slightly repressed in the young panicle of eui plants compared with WT plants.…”
Section: Ga Signaling Is Regulated By Eui Expressionmentioning
confidence: 99%
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“…In response to GA, DELLAs are rapidly degraded through the action of an SCF E3 ubiquitin (Ub) ligase (McGinnis et al, 2003;Sasaki et al, 2003). This involves the interaction of DELLAs with the SLEEPY1 (SLY1)/GIBBERELLIN-INSENSITIVE DWARF2 (GID2) F-box component through a direct protein-protein interaction, allowing their polyubiquitination and subsequent degradation by the 26S proteasome (Sasaki et al, 2003;Dill et al, 2004;Fu et al, 2004). All DELLA proteins contain an N-terminal DELLA domain and a C-terminal GRAS domain.…”
Section: Introductionmentioning
confidence: 99%
“…Recent studies show that GA derepresses its signaling pathway by inducing degradation of the DELLA proteins (Gomi and Matsuoka, 2003) and that this proteolysis event is targeted by a ubiquitin E3 ligase complex SCF SLY1/GID2 to the 26S proteasome (McGinnis et al, 2003;Sasaki et al, 2003). In wild-type plants, DELLA repressors are degraded in the presence of GA, and GA-promoted growth occurs (Silverstone et al, 2001;Gubler et al, 2002;Itoh et al, 2002).…”
mentioning
confidence: 99%