2005
DOI: 10.1117/1.1921887
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Abstract: This study represents the first reported use of photodynamic therapy (PDT) for metastatic bone lesions and specifically, as a treatment for spinal metastases. A model of bone metastasis in rat confirmed the efficacy of benzoporphyrin derivative-monoacid-mediated PDT for treating lesions within the spine and appendicular bone. Fluorimetry confirmed the selective accumulation of drug into the tumor(s) at 3 h post-injection. 48 h post-light delivery into the vertebral body of the rat spine loss of bioluminescent … Show more

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Cited by 39 publications
(40 citation statements)
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“…A safe and effective drug-light dose combination in this model appears to be 0.5 mg/kg BPD-MA (verteporfin) and applied light energy of less than 50 J for the thoracic spine and 1.0 mg/kg and 75 J for the lumbar spine. The higher tolerance of the lumbar spinal cord was observed by us also in a previous study [21]. In contrast to humans, where the spinal cord ends at the lumbar vertebrae (L) 1, it ends in the rat between lumbar vertebrae (L) 3/4 and in the pig between lumbar vertebrae (L) 5/6 [25].…”
Section: Discussionmentioning
confidence: 58%
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“…A safe and effective drug-light dose combination in this model appears to be 0.5 mg/kg BPD-MA (verteporfin) and applied light energy of less than 50 J for the thoracic spine and 1.0 mg/kg and 75 J for the lumbar spine. The higher tolerance of the lumbar spinal cord was observed by us also in a previous study [21]. In contrast to humans, where the spinal cord ends at the lumbar vertebrae (L) 1, it ends in the rat between lumbar vertebrae (L) 3/4 and in the pig between lumbar vertebrae (L) 5/6 [25].…”
Section: Discussionmentioning
confidence: 58%
“…However, we recognise the limitations of a rat model in this regard: in particular, species variations in vertebral bony architecture and differences in light transmission in metastaticallyinvolved vertebrae will have to be taken into account in the calculation of the safe and effective doses. Nevertheless, demonstration that there a significant therapeutic window exists supports the feasibility of this approach as a potential clinical modality [21,26].…”
Section: Discussionmentioning
confidence: 94%
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“…It was determined that a benzoporphyrin derivative monoacid dose of 0.5 mg/kg and a light dose of 50 J for thoracic vertebrae and 75 J for lumbar vertebrae was most effective in ablating tumor tissue while minimizing damage to the spinal cord. 22,26 Won et al 23 published a study demonstrating a bone-enhancing effect provided by PDT on healthy vertebrae. In this study, the effects of PDT on the structural integrity and strength of the spine was evaluated in healthy Wistar rats both 1 and 6 weeks after treatment.…”
Section: Risk Of Bias In Included Clinical Trialsmentioning
confidence: 99%
“…Burch et al also successfully used a cannulated approach to administer PDT to a single vertebral body in a porcine model, demonstrating the feasibility of applying such a technique to humans. 26 Photodynamic therapy was found to destroy bone marrow cells, adversely affecting osteoclasts. This may be clinically advantageous, as osteoclasts have a symbiotic relationship with tumor cells in skeletal resorption.…”
Section: Risk Of Bias In Included Clinical Trialsmentioning
confidence: 99%