1992
DOI: 10.1111/j.1751-1097.1992.tb02191.x
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Abstract: The photoactivated antiviral and cytotoxic activities of the naturally occurring thiophene, alpha-terthienyl (1), and 15 synthetic analogues were evaluated against murine cytomegalovirus and Sindbis virus, and murine mastocytoma cells. After irradiation with near UV light, alpha-terthienyl and most of its analogues had significant toxicity, with minimum inhibitory concentrations in the range of 0.02-40 microM. In the absence of near UV irradiation, only one analogue had antiviral activity and five were cytotox… Show more

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Cited by 81 publications
(29 citation statements)
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References 46 publications
(41 reference statements)
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“…For example, terthiophenes isolated from Porophyllum ruderale exhibit strong toxicity against promastigote and axenic amastigote forms of Leishmania amazonensis (Takahashi et al, 2011). In addition, terthiophenes were reported to have significant anti-viral and cytotoxic activities against murine cytomegalovirus, sindbis virus, and murine mastocytoma cells (Marles et al, 1992). Anti-HIV (Hudson et al, 1993) and inhibitory activities against protein kinase C ( Kim et al, 1998) were also suggested.…”
Section: Compoundmentioning
confidence: 97%
“…For example, terthiophenes isolated from Porophyllum ruderale exhibit strong toxicity against promastigote and axenic amastigote forms of Leishmania amazonensis (Takahashi et al, 2011). In addition, terthiophenes were reported to have significant anti-viral and cytotoxic activities against murine cytomegalovirus, sindbis virus, and murine mastocytoma cells (Marles et al, 1992). Anti-HIV (Hudson et al, 1993) and inhibitory activities against protein kinase C ( Kim et al, 1998) were also suggested.…”
Section: Compoundmentioning
confidence: 97%
“…The roots of E. grijissi (commercial Chinese name: Yuzhou Loulu) are listed in Chinese Pharmacopeia and used to clear heat, expel miasma, and stimulate milk secretion for a long history [2]. Previous chemical investigation on the roots of E. grijissi demonstrated the presence of essential oil [3] and thiophenes [4 -8], which have been proven to possess anti-tumor [9,10], insecticide [11,12], anti-virus [9,13,14], and anti-inflammatory activities [15]. Our previous research showed that the CH 2 Cl 2 extract possessed medium cytotoxic activity [16].…”
Section: Introductionmentioning
confidence: 99%
“…The root of E. grijisii (commercial Chinese name: Yuzhou Loulu) is listed in "Chinese Pharmacopeia" and is used to clear heat, expel miasma and stimulate milk secretion (National Pharmacopoeia Committee, 2005). Previous chemical investigations on the root of E. grijisii demonstrated the presence of essential oil (Guo et al, 1994) and thiophenes (Guo et al, 1992;Koike et al, 1999;Lin et al, 1999;Liu et al, 2002), which have been proven to possess several activities, like antitumour (Lambert et al 1991;Marles et al, 1992), insect (Nivsarkar et al, 1991;Sharma and Goel, 1994), antivirus (Hudson et al, 1993;Marles et al, 1992) and anti-infl ammatory (Lin et al, 1992).…”
Section: Introductionmentioning
confidence: 99%