Environmental Hazards and Birth Defects

Janerich, Dwight T.

doi:10.1111/j.1749-6632.1979.tb15330.x

Annals of the New York Academy of Sciences

1979

DOI: 10.1111/j.1749-6632.1979.tb15330.x

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Environmental Hazards and Birth Defects

Dwight T. Janerich

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1983

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Cited by 3 publications

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Uses of Available Record Systems in Epidemiologic Studies of Reproductive Toxicology

Polednak

Janerich

1983

American J Industrial Med

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The uses of available record systems in epidemiologic studies of reproductive toxicology are described with reference to New York State. The available record systems (and relevant reproductive end points) described include: a newborn screening program for metabolic diseases and hemoglobinopathies (relevant to point mutations); chromosome registries and prenatal cytogenetics (for chromosome anomalies); live birth certificates (for birth defects, birthweight, sex ratio, etc); fetal death certificates (for spontaneous fetal deaths); and a statewide cancer registry (for childhood cancers and transplacental carcinogenesis). The uses and limitations of these record systems are discussed, along with examples of their use in descriptive and analytic epidemiologic studies. Descriptive studies outlined include investigations of temporal and geographic trends in birth defects, birth weight, and fetal deaths, with reference to environmental questions (eg, Love Canal, nuclear power plants). Analytic studies described concern parental occupation in relation to specific birth defects (neural tube defects and Down syndrome) and maternal use of contraceptive drugs.

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Uses of Available Record Systems in Epidemiologic Studies of Reproductive Toxicology

Polednak

Janerich

1983

American J Industrial Med

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Uses of available record systems in epidemiologic studies of reproductive toxicology

Polednak

Janerich

1983

Am. J. Ind. Med.

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Carbon disulphide intrauterine sensitization

Tabacova

Nikiforov

Balabaeva

1983

J of Applied Toxicology

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This study was designed to evaluate the effect of carbon disulphide (CS2) exposure during pregnancy in two subsequent generations. Albino rats (F1), which had been prenatally exposed by maternal inhalation to teratogenic (200 and 100 mg m-3) and subteratogenic (10 and 0.03 mg m-3) concentrations of CS2, were reared until maturity and mated to produce an F2 generation. During pregnancy the F1 females were again subjected to CS2 exposure at the same concentrations as the F0 females throughout gestation. Pre- and postnatal development of F1 and F2 generations, as well as the corresponding maternal effects, were studied. Embryonic lethality, weight, congenital malformations, indices of lipid and energy metabolism, DNA and some liver drug metabolizing enzymes in maternal and fetal tissues were studied at term. Postnatal viability, physical and behavioral development, and hexobarbital sleeping time of the progeny were evaluated. Comparisons of CS2 effect on F1 and F2 generations were performed. A marked increase in CS2-induced teratogenicity was found in the F2 generation, together with retarded development of MFO system and increased postnatal behavioral effects. The results point to intrauterine sensitization of progeny to CS2. This effect is discussed in the light of possible interference of the agent with the hormonal programming of intrauterine development.

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Environmental Hazards and Birth Defects

Cited by 3 publications

References 11 publications

Uses of Available Record Systems in Epidemiologic Studies of Reproductive Toxicology

Uses of Available Record Systems in Epidemiologic Studies of Reproductive Toxicology

Uses of available record systems in epidemiologic studies of reproductive toxicology

Carbon disulphide intrauterine sensitization

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